CDK2 limits the highly energetic secretory program of mature β cells by restricting PEP cycle-dependent K(ATP) channel closure

Hallmarks of mature β cells are restricted proliferation and a highly energetic secretory state. Paradoxically, cyclin-dependent kinase 2 (CDK2) is synthesized throughout adulthood, its cytosolic localization raising the likelihood of cell cycle-independent functions. In the absence of any changes i...

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Detalles Bibliográficos
Autores principales: Sdao, Sophia M., Ho, Thuong, Poudel, Chetan, Foster, Hannah R., De Leon, Elizabeth R., Adams, Melissa T., Lee, Ji-Hyeon, Blum, Barak, Rane, Sushil G., Merrins, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7882066/
https://www.ncbi.nlm.nih.gov/pubmed/33503433
http://dx.doi.org/10.1016/j.celrep.2021.108690

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