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Associations between WTAP gene polymorphisms and neuroblastoma susceptibility in Chinese children
BACKGROUND: Previous studies have revealed that WTAP is related to multiple types of cancer. Recently, WTAP has been reported as an independent prognostic factor in patients with neuroblastoma. METHODS: To explore the association between three WTAP polymorphisms (rs9457712 G>A, rs1853259 A>G a...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7882302/ https://www.ncbi.nlm.nih.gov/pubmed/33633946 http://dx.doi.org/10.21037/tp-20-168 |
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author | Tang, Jue Lu, Hongting Yang, Zhonghua Li, Le Li, Li Zhang, Jiao Cheng, Jiwen Li, Yong Li, Suhong Zhou, Haixia He, Jing Liu, Wei |
author_facet | Tang, Jue Lu, Hongting Yang, Zhonghua Li, Le Li, Li Zhang, Jiao Cheng, Jiwen Li, Yong Li, Suhong Zhou, Haixia He, Jing Liu, Wei |
author_sort | Tang, Jue |
collection | PubMed |
description | BACKGROUND: Previous studies have revealed that WTAP is related to multiple types of cancer. Recently, WTAP has been reported as an independent prognostic factor in patients with neuroblastoma. METHODS: To explore the association between three WTAP polymorphisms (rs9457712 G>A, rs1853259 A>G and rs7766006 G>T) and neuroblastoma susceptibility in Chinese populations, we performed this case-control study including 898 neuroblastoma cases and 1,734 controls. We genotyped these potentially functional single nucleotide polymorphisms (SNPs) by TaqMan assays. The odds ratios (ORs) and 95% confidence intervals (CIs) by logistic regression models were used to assess the relationship between WTAP SNPs and the risk of neuroblastoma. RESULTS: No significant associations were observed in the overall analysis between any of the three WTAP polymorphisms and the risk of neuroblastoma. However, in the age ≤18 months subgroup, we found that the rs1853259 AG/GG genotype exerted protective effects against neuroblastoma (adjusted OR =0.77, 95% CI: 0.59–0.998, P=0.048), whereas the presence of 1–2 combined risk genotypes significantly increased the risk of neuroblastoma (adjusted OR =1.32, 95% CI: 1.02–1.71, P=0.036). CONCLUSIONS: WTAP gene polymorphisms only have a weak impact on the risk of neuroblastoma in the Chinese children. Further case-control studies, preferable on larger sample sizes, are needed to validate our results. |
format | Online Article Text |
id | pubmed-7882302 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-78823022021-02-24 Associations between WTAP gene polymorphisms and neuroblastoma susceptibility in Chinese children Tang, Jue Lu, Hongting Yang, Zhonghua Li, Le Li, Li Zhang, Jiao Cheng, Jiwen Li, Yong Li, Suhong Zhou, Haixia He, Jing Liu, Wei Transl Pediatr Original Article BACKGROUND: Previous studies have revealed that WTAP is related to multiple types of cancer. Recently, WTAP has been reported as an independent prognostic factor in patients with neuroblastoma. METHODS: To explore the association between three WTAP polymorphisms (rs9457712 G>A, rs1853259 A>G and rs7766006 G>T) and neuroblastoma susceptibility in Chinese populations, we performed this case-control study including 898 neuroblastoma cases and 1,734 controls. We genotyped these potentially functional single nucleotide polymorphisms (SNPs) by TaqMan assays. The odds ratios (ORs) and 95% confidence intervals (CIs) by logistic regression models were used to assess the relationship between WTAP SNPs and the risk of neuroblastoma. RESULTS: No significant associations were observed in the overall analysis between any of the three WTAP polymorphisms and the risk of neuroblastoma. However, in the age ≤18 months subgroup, we found that the rs1853259 AG/GG genotype exerted protective effects against neuroblastoma (adjusted OR =0.77, 95% CI: 0.59–0.998, P=0.048), whereas the presence of 1–2 combined risk genotypes significantly increased the risk of neuroblastoma (adjusted OR =1.32, 95% CI: 1.02–1.71, P=0.036). CONCLUSIONS: WTAP gene polymorphisms only have a weak impact on the risk of neuroblastoma in the Chinese children. Further case-control studies, preferable on larger sample sizes, are needed to validate our results. AME Publishing Company 2021-01 /pmc/articles/PMC7882302/ /pubmed/33633946 http://dx.doi.org/10.21037/tp-20-168 Text en 2021 Translational Pediatrics. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Original Article Tang, Jue Lu, Hongting Yang, Zhonghua Li, Le Li, Li Zhang, Jiao Cheng, Jiwen Li, Yong Li, Suhong Zhou, Haixia He, Jing Liu, Wei Associations between WTAP gene polymorphisms and neuroblastoma susceptibility in Chinese children |
title | Associations between WTAP gene polymorphisms and neuroblastoma susceptibility in Chinese children |
title_full | Associations between WTAP gene polymorphisms and neuroblastoma susceptibility in Chinese children |
title_fullStr | Associations between WTAP gene polymorphisms and neuroblastoma susceptibility in Chinese children |
title_full_unstemmed | Associations between WTAP gene polymorphisms and neuroblastoma susceptibility in Chinese children |
title_short | Associations between WTAP gene polymorphisms and neuroblastoma susceptibility in Chinese children |
title_sort | associations between wtap gene polymorphisms and neuroblastoma susceptibility in chinese children |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7882302/ https://www.ncbi.nlm.nih.gov/pubmed/33633946 http://dx.doi.org/10.21037/tp-20-168 |
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