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Reduced Facilitation of Parietal-Motor Functional Connections in Older Adults

Age-related changes in cortico-cortical connectivity in the human motor network in older adults are associated with declines in hand dexterity. Posterior parietal cortex (PPC) is strongly interconnected with motor areas and plays a critical role in many aspects of motor planning. Functional connecti...

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Detalles Bibliográficos
Autores principales: Goldenkoff, Elana R., Logue, Rachel N., Brown, Susan H., Vesia, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7882479/
https://www.ncbi.nlm.nih.gov/pubmed/33597858
http://dx.doi.org/10.3389/fnagi.2021.595288
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author Goldenkoff, Elana R.
Logue, Rachel N.
Brown, Susan H.
Vesia, Michael
author_facet Goldenkoff, Elana R.
Logue, Rachel N.
Brown, Susan H.
Vesia, Michael
author_sort Goldenkoff, Elana R.
collection PubMed
description Age-related changes in cortico-cortical connectivity in the human motor network in older adults are associated with declines in hand dexterity. Posterior parietal cortex (PPC) is strongly interconnected with motor areas and plays a critical role in many aspects of motor planning. Functional connectivity measures derived from dual-site transcranial magnetic stimulation (dsTMS) studies have found facilitatory inputs from PPC to ipsilateral primary motor cortex (M1) in younger adults. In this study, we investigated whether facilitatory inputs from PPC to M1 are altered by age. We used dsTMS in a conditioning-test paradigm to characterize patterns of functional connectivity between the left PPC and ipsilateral M1 and a standard pegboard test to assess skilled hand motor function in 13 young and 13 older adults. We found a PPC-M1 facilitation in young adults but not older adults. Older adults also showed a decline in motor performance compared to young adults. We conclude that the reduced PPC-M1 facilitation in older adults may be an early marker of age-related decline in the neural control of movement.
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spelling pubmed-78824792021-02-16 Reduced Facilitation of Parietal-Motor Functional Connections in Older Adults Goldenkoff, Elana R. Logue, Rachel N. Brown, Susan H. Vesia, Michael Front Aging Neurosci Neuroscience Age-related changes in cortico-cortical connectivity in the human motor network in older adults are associated with declines in hand dexterity. Posterior parietal cortex (PPC) is strongly interconnected with motor areas and plays a critical role in many aspects of motor planning. Functional connectivity measures derived from dual-site transcranial magnetic stimulation (dsTMS) studies have found facilitatory inputs from PPC to ipsilateral primary motor cortex (M1) in younger adults. In this study, we investigated whether facilitatory inputs from PPC to M1 are altered by age. We used dsTMS in a conditioning-test paradigm to characterize patterns of functional connectivity between the left PPC and ipsilateral M1 and a standard pegboard test to assess skilled hand motor function in 13 young and 13 older adults. We found a PPC-M1 facilitation in young adults but not older adults. Older adults also showed a decline in motor performance compared to young adults. We conclude that the reduced PPC-M1 facilitation in older adults may be an early marker of age-related decline in the neural control of movement. Frontiers Media S.A. 2021-02-01 /pmc/articles/PMC7882479/ /pubmed/33597858 http://dx.doi.org/10.3389/fnagi.2021.595288 Text en Copyright © 2021 Goldenkoff, Logue, Brown and Vesia. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Goldenkoff, Elana R.
Logue, Rachel N.
Brown, Susan H.
Vesia, Michael
Reduced Facilitation of Parietal-Motor Functional Connections in Older Adults
title Reduced Facilitation of Parietal-Motor Functional Connections in Older Adults
title_full Reduced Facilitation of Parietal-Motor Functional Connections in Older Adults
title_fullStr Reduced Facilitation of Parietal-Motor Functional Connections in Older Adults
title_full_unstemmed Reduced Facilitation of Parietal-Motor Functional Connections in Older Adults
title_short Reduced Facilitation of Parietal-Motor Functional Connections in Older Adults
title_sort reduced facilitation of parietal-motor functional connections in older adults
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7882479/
https://www.ncbi.nlm.nih.gov/pubmed/33597858
http://dx.doi.org/10.3389/fnagi.2021.595288
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