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Reduced Facilitation of Parietal-Motor Functional Connections in Older Adults
Age-related changes in cortico-cortical connectivity in the human motor network in older adults are associated with declines in hand dexterity. Posterior parietal cortex (PPC) is strongly interconnected with motor areas and plays a critical role in many aspects of motor planning. Functional connecti...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7882479/ https://www.ncbi.nlm.nih.gov/pubmed/33597858 http://dx.doi.org/10.3389/fnagi.2021.595288 |
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author | Goldenkoff, Elana R. Logue, Rachel N. Brown, Susan H. Vesia, Michael |
author_facet | Goldenkoff, Elana R. Logue, Rachel N. Brown, Susan H. Vesia, Michael |
author_sort | Goldenkoff, Elana R. |
collection | PubMed |
description | Age-related changes in cortico-cortical connectivity in the human motor network in older adults are associated with declines in hand dexterity. Posterior parietal cortex (PPC) is strongly interconnected with motor areas and plays a critical role in many aspects of motor planning. Functional connectivity measures derived from dual-site transcranial magnetic stimulation (dsTMS) studies have found facilitatory inputs from PPC to ipsilateral primary motor cortex (M1) in younger adults. In this study, we investigated whether facilitatory inputs from PPC to M1 are altered by age. We used dsTMS in a conditioning-test paradigm to characterize patterns of functional connectivity between the left PPC and ipsilateral M1 and a standard pegboard test to assess skilled hand motor function in 13 young and 13 older adults. We found a PPC-M1 facilitation in young adults but not older adults. Older adults also showed a decline in motor performance compared to young adults. We conclude that the reduced PPC-M1 facilitation in older adults may be an early marker of age-related decline in the neural control of movement. |
format | Online Article Text |
id | pubmed-7882479 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78824792021-02-16 Reduced Facilitation of Parietal-Motor Functional Connections in Older Adults Goldenkoff, Elana R. Logue, Rachel N. Brown, Susan H. Vesia, Michael Front Aging Neurosci Neuroscience Age-related changes in cortico-cortical connectivity in the human motor network in older adults are associated with declines in hand dexterity. Posterior parietal cortex (PPC) is strongly interconnected with motor areas and plays a critical role in many aspects of motor planning. Functional connectivity measures derived from dual-site transcranial magnetic stimulation (dsTMS) studies have found facilitatory inputs from PPC to ipsilateral primary motor cortex (M1) in younger adults. In this study, we investigated whether facilitatory inputs from PPC to M1 are altered by age. We used dsTMS in a conditioning-test paradigm to characterize patterns of functional connectivity between the left PPC and ipsilateral M1 and a standard pegboard test to assess skilled hand motor function in 13 young and 13 older adults. We found a PPC-M1 facilitation in young adults but not older adults. Older adults also showed a decline in motor performance compared to young adults. We conclude that the reduced PPC-M1 facilitation in older adults may be an early marker of age-related decline in the neural control of movement. Frontiers Media S.A. 2021-02-01 /pmc/articles/PMC7882479/ /pubmed/33597858 http://dx.doi.org/10.3389/fnagi.2021.595288 Text en Copyright © 2021 Goldenkoff, Logue, Brown and Vesia. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Goldenkoff, Elana R. Logue, Rachel N. Brown, Susan H. Vesia, Michael Reduced Facilitation of Parietal-Motor Functional Connections in Older Adults |
title | Reduced Facilitation of Parietal-Motor Functional Connections in Older Adults |
title_full | Reduced Facilitation of Parietal-Motor Functional Connections in Older Adults |
title_fullStr | Reduced Facilitation of Parietal-Motor Functional Connections in Older Adults |
title_full_unstemmed | Reduced Facilitation of Parietal-Motor Functional Connections in Older Adults |
title_short | Reduced Facilitation of Parietal-Motor Functional Connections in Older Adults |
title_sort | reduced facilitation of parietal-motor functional connections in older adults |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7882479/ https://www.ncbi.nlm.nih.gov/pubmed/33597858 http://dx.doi.org/10.3389/fnagi.2021.595288 |
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