Roles of Non-coding RNAs in Central Nervous System Axon Regeneration

Axons in the central nervous system often fail to regenerate after injury due to the limited intrinsic regeneration ability of the central nervous system (CNS) and complex extracellular inhibitory factors. Therefore, it is of vital importance to have a better understanding of potential methods to pr...

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Autores principales: Li, Pei, Jia, Yuanyuan, Tang, Wenbo, Cui, Qingjun, Liu, Ming, Jiang, Jingjing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7882506/
https://www.ncbi.nlm.nih.gov/pubmed/33597844
http://dx.doi.org/10.3389/fnins.2021.630633
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author Li, Pei
Jia, Yuanyuan
Tang, Wenbo
Cui, Qingjun
Liu, Ming
Jiang, Jingjing
author_facet Li, Pei
Jia, Yuanyuan
Tang, Wenbo
Cui, Qingjun
Liu, Ming
Jiang, Jingjing
author_sort Li, Pei
collection PubMed
description Axons in the central nervous system often fail to regenerate after injury due to the limited intrinsic regeneration ability of the central nervous system (CNS) and complex extracellular inhibitory factors. Therefore, it is of vital importance to have a better understanding of potential methods to promote the regeneration capability of injured nerves. Evidence has shown that non-coding RNAs play an essential role in nerve regeneration, especially long non-coding RNA (lncRNA), microRNA (miRNA), and circular RNA (circRNA). In this review, we profile their separate roles in axon regeneration after CNS injuries, such as spinal cord injury (SCI) and optic nerve injury. In addition, we also reveal the interactive networks among non-coding RNAs.
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spelling pubmed-78825062021-02-16 Roles of Non-coding RNAs in Central Nervous System Axon Regeneration Li, Pei Jia, Yuanyuan Tang, Wenbo Cui, Qingjun Liu, Ming Jiang, Jingjing Front Neurosci Neuroscience Axons in the central nervous system often fail to regenerate after injury due to the limited intrinsic regeneration ability of the central nervous system (CNS) and complex extracellular inhibitory factors. Therefore, it is of vital importance to have a better understanding of potential methods to promote the regeneration capability of injured nerves. Evidence has shown that non-coding RNAs play an essential role in nerve regeneration, especially long non-coding RNA (lncRNA), microRNA (miRNA), and circular RNA (circRNA). In this review, we profile their separate roles in axon regeneration after CNS injuries, such as spinal cord injury (SCI) and optic nerve injury. In addition, we also reveal the interactive networks among non-coding RNAs. Frontiers Media S.A. 2021-02-01 /pmc/articles/PMC7882506/ /pubmed/33597844 http://dx.doi.org/10.3389/fnins.2021.630633 Text en Copyright © 2021 Li, Jia, Tang, Cui, Liu and Jiang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Li, Pei
Jia, Yuanyuan
Tang, Wenbo
Cui, Qingjun
Liu, Ming
Jiang, Jingjing
Roles of Non-coding RNAs in Central Nervous System Axon Regeneration
title Roles of Non-coding RNAs in Central Nervous System Axon Regeneration
title_full Roles of Non-coding RNAs in Central Nervous System Axon Regeneration
title_fullStr Roles of Non-coding RNAs in Central Nervous System Axon Regeneration
title_full_unstemmed Roles of Non-coding RNAs in Central Nervous System Axon Regeneration
title_short Roles of Non-coding RNAs in Central Nervous System Axon Regeneration
title_sort roles of non-coding rnas in central nervous system axon regeneration
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7882506/
https://www.ncbi.nlm.nih.gov/pubmed/33597844
http://dx.doi.org/10.3389/fnins.2021.630633
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