Sunitinib and Imatinib Display Differential Cardiotoxicity in Adult Rat Cardiac Fibroblasts That Involves a Role for Calcium/Calmodulin Dependent Protein Kinase II

Background: Tyrosine kinase inhibitors (TKIs) have dramatically improved cancer treatment but are known to cause cardiotoxicity. The pathophysiological consequences of TKI therapy are likely to manifest across different cell types of the heart, yet there is little understanding of the differential a...

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Detalles Bibliográficos
Autores principales: McMullen, Calum J., Chalmers, Susan, Wood, Rachel, Cunningham, Margaret R., Currie, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7882511/
https://www.ncbi.nlm.nih.gov/pubmed/33598481
http://dx.doi.org/10.3389/fcvm.2020.630480

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7882511/
https://www.ncbi.nlm.nih.gov/pubmed/33598481
http://dx.doi.org/10.3389/fcvm.2020.630480

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