Current Insights and Future Prospects for Targeting IL-17 to Treat Patients With Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by immune cell abnormalities which lead to the production of autoantibodies and the deposition of immune complexes. Interleukin (IL)-17-producing cells play an important role in the pathogenesis of the disease, making them an...

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Autores principales: Koga, Tomohiro, Ichinose, Kunihiro, Kawakami, Atsushi, Tsokos, George C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7882681/
https://www.ncbi.nlm.nih.gov/pubmed/33597953
http://dx.doi.org/10.3389/fimmu.2020.624971
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author Koga, Tomohiro
Ichinose, Kunihiro
Kawakami, Atsushi
Tsokos, George C.
author_facet Koga, Tomohiro
Ichinose, Kunihiro
Kawakami, Atsushi
Tsokos, George C.
author_sort Koga, Tomohiro
collection PubMed
description Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by immune cell abnormalities which lead to the production of autoantibodies and the deposition of immune complexes. Interleukin (IL)-17-producing cells play an important role in the pathogenesis of the disease, making them an attractive therapeutic target. Studies in lupus-prone mice and of ex vivo cells from patients with SLE humans have shown that IL-17 represents a promising therapeutic target. Here we review molecular mechanisms involved in IL-17 production and Th17 cell differentiation and function and an update on the role of IL-17 in autoimmune diseases and the expected usefulness for targeting IL-17 therapeutically.
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spelling pubmed-78826812021-02-16 Current Insights and Future Prospects for Targeting IL-17 to Treat Patients With Systemic Lupus Erythematosus Koga, Tomohiro Ichinose, Kunihiro Kawakami, Atsushi Tsokos, George C. Front Immunol Immunology Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by immune cell abnormalities which lead to the production of autoantibodies and the deposition of immune complexes. Interleukin (IL)-17-producing cells play an important role in the pathogenesis of the disease, making them an attractive therapeutic target. Studies in lupus-prone mice and of ex vivo cells from patients with SLE humans have shown that IL-17 represents a promising therapeutic target. Here we review molecular mechanisms involved in IL-17 production and Th17 cell differentiation and function and an update on the role of IL-17 in autoimmune diseases and the expected usefulness for targeting IL-17 therapeutically. Frontiers Media S.A. 2021-02-01 /pmc/articles/PMC7882681/ /pubmed/33597953 http://dx.doi.org/10.3389/fimmu.2020.624971 Text en Copyright © 2021 Koga, Ichinose, Kawakami and Tsokos http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Koga, Tomohiro
Ichinose, Kunihiro
Kawakami, Atsushi
Tsokos, George C.
Current Insights and Future Prospects for Targeting IL-17 to Treat Patients With Systemic Lupus Erythematosus
title Current Insights and Future Prospects for Targeting IL-17 to Treat Patients With Systemic Lupus Erythematosus
title_full Current Insights and Future Prospects for Targeting IL-17 to Treat Patients With Systemic Lupus Erythematosus
title_fullStr Current Insights and Future Prospects for Targeting IL-17 to Treat Patients With Systemic Lupus Erythematosus
title_full_unstemmed Current Insights and Future Prospects for Targeting IL-17 to Treat Patients With Systemic Lupus Erythematosus
title_short Current Insights and Future Prospects for Targeting IL-17 to Treat Patients With Systemic Lupus Erythematosus
title_sort current insights and future prospects for targeting il-17 to treat patients with systemic lupus erythematosus
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7882681/
https://www.ncbi.nlm.nih.gov/pubmed/33597953
http://dx.doi.org/10.3389/fimmu.2020.624971
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