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Tumor Burden and Immunotherapy: Impact on Immune Infiltration and Therapeutic Outcomes
Cancer immunotherapy has revolutionized the treatment landscape in medical oncology, but its efficacy has been variable across patients. Biomarkers to predict such differential response to immunotherapy include cytotoxic T lymphocyte infiltration, tumor mutational burden, and microsatellite instabil...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7882695/ https://www.ncbi.nlm.nih.gov/pubmed/33597954 http://dx.doi.org/10.3389/fimmu.2020.629722 |
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author | Kim, Samuel I. Cassella, Christopher R. Byrne, Katelyn T. |
author_facet | Kim, Samuel I. Cassella, Christopher R. Byrne, Katelyn T. |
author_sort | Kim, Samuel I. |
collection | PubMed |
description | Cancer immunotherapy has revolutionized the treatment landscape in medical oncology, but its efficacy has been variable across patients. Biomarkers to predict such differential response to immunotherapy include cytotoxic T lymphocyte infiltration, tumor mutational burden, and microsatellite instability. A growing number of studies also suggest that baseline tumor burden, or tumor size, predicts response to immunotherapy. In this review, we discuss the changes in immune profile and therapeutic responses that occur with increasing tumor size. We also overview therapeutic approaches to reduce tumor burden and favorably modulate the immune microenvironment of larger tumors. |
format | Online Article Text |
id | pubmed-7882695 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78826952021-02-16 Tumor Burden and Immunotherapy: Impact on Immune Infiltration and Therapeutic Outcomes Kim, Samuel I. Cassella, Christopher R. Byrne, Katelyn T. Front Immunol Immunology Cancer immunotherapy has revolutionized the treatment landscape in medical oncology, but its efficacy has been variable across patients. Biomarkers to predict such differential response to immunotherapy include cytotoxic T lymphocyte infiltration, tumor mutational burden, and microsatellite instability. A growing number of studies also suggest that baseline tumor burden, or tumor size, predicts response to immunotherapy. In this review, we discuss the changes in immune profile and therapeutic responses that occur with increasing tumor size. We also overview therapeutic approaches to reduce tumor burden and favorably modulate the immune microenvironment of larger tumors. Frontiers Media S.A. 2021-02-01 /pmc/articles/PMC7882695/ /pubmed/33597954 http://dx.doi.org/10.3389/fimmu.2020.629722 Text en Copyright © 2021 Kim, Cassella and Byrne http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Kim, Samuel I. Cassella, Christopher R. Byrne, Katelyn T. Tumor Burden and Immunotherapy: Impact on Immune Infiltration and Therapeutic Outcomes |
title | Tumor Burden and Immunotherapy: Impact on Immune Infiltration and Therapeutic Outcomes |
title_full | Tumor Burden and Immunotherapy: Impact on Immune Infiltration and Therapeutic Outcomes |
title_fullStr | Tumor Burden and Immunotherapy: Impact on Immune Infiltration and Therapeutic Outcomes |
title_full_unstemmed | Tumor Burden and Immunotherapy: Impact on Immune Infiltration and Therapeutic Outcomes |
title_short | Tumor Burden and Immunotherapy: Impact on Immune Infiltration and Therapeutic Outcomes |
title_sort | tumor burden and immunotherapy: impact on immune infiltration and therapeutic outcomes |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7882695/ https://www.ncbi.nlm.nih.gov/pubmed/33597954 http://dx.doi.org/10.3389/fimmu.2020.629722 |
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