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Guidance for Demonstrating the Societal Value of new Antibiotics
Given that antibiotic use is associated with externalities, standard economic evaluation which considers costs and health gains accruing to patients under-values antibiotics. Informed by a scoping review, this discussion paper aims to identify the societal value elements of antibiotics and to provid...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7882732/ https://www.ncbi.nlm.nih.gov/pubmed/33597882 http://dx.doi.org/10.3389/fphar.2020.618238 |
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author | Simoens, Steven Spriet, Isabel |
author_facet | Simoens, Steven Spriet, Isabel |
author_sort | Simoens, Steven |
collection | PubMed |
description | Given that antibiotic use is associated with externalities, standard economic evaluation which considers costs and health gains accruing to patients under-values antibiotics. Informed by a scoping review, this discussion paper aims to identify the societal value elements of antibiotics and to provide guidance on how these value elements can be incorporated in economic evaluation. With a view to appropriately quantify the societal value of antibiotics, there is a need for good practice guidelines on the methodology of economic evaluation for such products. We argue that it is important to assess antibiotics at population level to account for their transmission, diversity, insurance, spectrum, novel action and enablement values. In addition to the value of antibiotics to infected patients, economic evaluations need to use modeling approaches to explore the impact of different modes of employing new and existing antibiotics (for example, as last resort treatment) on disease transmission and resistance development in current and future patients. Hence, assessing the value of antibiotics also involves an ethical dimension. Further work is required about how the multiple value elements of antibiotics are linked to each other and how they can be aggregated. |
format | Online Article Text |
id | pubmed-7882732 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78827322021-02-16 Guidance for Demonstrating the Societal Value of new Antibiotics Simoens, Steven Spriet, Isabel Front Pharmacol Pharmacology Given that antibiotic use is associated with externalities, standard economic evaluation which considers costs and health gains accruing to patients under-values antibiotics. Informed by a scoping review, this discussion paper aims to identify the societal value elements of antibiotics and to provide guidance on how these value elements can be incorporated in economic evaluation. With a view to appropriately quantify the societal value of antibiotics, there is a need for good practice guidelines on the methodology of economic evaluation for such products. We argue that it is important to assess antibiotics at population level to account for their transmission, diversity, insurance, spectrum, novel action and enablement values. In addition to the value of antibiotics to infected patients, economic evaluations need to use modeling approaches to explore the impact of different modes of employing new and existing antibiotics (for example, as last resort treatment) on disease transmission and resistance development in current and future patients. Hence, assessing the value of antibiotics also involves an ethical dimension. Further work is required about how the multiple value elements of antibiotics are linked to each other and how they can be aggregated. Frontiers Media S.A. 2021-02-01 /pmc/articles/PMC7882732/ /pubmed/33597882 http://dx.doi.org/10.3389/fphar.2020.618238 Text en Copyright © 2021 Simoens and Spriet. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Simoens, Steven Spriet, Isabel Guidance for Demonstrating the Societal Value of new Antibiotics |
title | Guidance for Demonstrating the Societal Value of new Antibiotics |
title_full | Guidance for Demonstrating the Societal Value of new Antibiotics |
title_fullStr | Guidance for Demonstrating the Societal Value of new Antibiotics |
title_full_unstemmed | Guidance for Demonstrating the Societal Value of new Antibiotics |
title_short | Guidance for Demonstrating the Societal Value of new Antibiotics |
title_sort | guidance for demonstrating the societal value of new antibiotics |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7882732/ https://www.ncbi.nlm.nih.gov/pubmed/33597882 http://dx.doi.org/10.3389/fphar.2020.618238 |
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