Cargando…

Squalene epoxidase expression is associated with breast tumor progression and with a poor prognosis in breast cancer

Differentially expressed genes (DEGs) have been previously identified using massive parallel RNA sequencing in matched normal, breast cancer (BC) and nodal metastatic tissues. Squalene epoxidase (SQLE), one of these DEGs, is a key enzyme in cholesterol synthesis. The aim of the present study was to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Nah Ihm, Park, Min Ho, Kweon, Sun-Seog, Cho, Namki, Lee, Ji Shin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7882892/ https://www.ncbi.nlm.nih.gov/pubmed/33664822 http://dx.doi.org/10.3892/ol.2021.12520

Ejemplares similares

Squalene synthase predicts poor prognosis in stage I‐III colon adenocarcinoma and synergizes squalene epoxidase to promote tumor progression
por: Jiang, Huihong, et al.
Publicado: (2022)

Metabolic coupling in phyllodes tumor of the breast and its association with tumor progression
por: Kim, Nah Ihm, et al.
Publicado: (2023)

Functional characterization of squalene synthase and squalene epoxidase in Taraxacum koksaghyz
por: Unland, Kristina, et al.
Publicado: (2018)

Accumulation of Squalene in a Microalga Chlamydomonas reinhardtii by Genetic Modification of Squalene Synthase and Squalene Epoxidase Genes
por: Kajikawa, Masataka, et al.
Publicado: (2015)

Squalene epoxidase is a bona fide oncogene by amplification with clinical relevance in breast cancer
por: Brown, David N., et al.
Publicado: (2016)

Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase
por: Padyana, Anil K., et al.
Publicado: (2019)

The shape of human squalene epoxidase expands the arsenal against cancer
por: Brown, Andrew J., et al.
Publicado: (2019)

Targeting Squalene Epoxidase Confers Metabolic Vulnerability and Overcomes Chemoresistance in HNSCC
por: Zhao, Xinyuan, et al.
Publicado: (2023)

Comparison of the Clinicopathologic Features and T-Cell Infiltration of B7-H3 and B7-H4 Expression in Triple-negative Breast Cancer Subtypes
por: Kim, Nah Ihm, et al.
Publicado: (2022)

Lipid saturation induces degradation of squalene epoxidase for sterol homeostasis and cell survival
por: Huang, Leng-Jie, et al.
Publicado: (2022)

p53 and MYC-regulated squalene epoxidase as Achilles heel in colorectal cancer
por: Fischer, Martin
Publicado: (2023)

Co-production of ethanol and squalene using a Saccharomyces cerevisiae ERG1 (squalene epoxidase) mutant and agro-industrial feedstock
por: Hull, Claire M, et al.
Publicado: (2014)

Isolation and Characterization of Two Squalene Epoxidase Genes from Botryococcus braunii, Race B
por: Uchida, Hidenobu, et al.
Publicado: (2015)

Antifungal Susceptibility and Mutations in the Squalene Epoxidase Gene in Dermatophytes of the Trichophyton mentagrophytes Species Complex
por: Kong, Xue, et al.
Publicado: (2021)

Squalene epoxidase, located on chromosome 8q24.1, is upregulated in 8q+ breast cancer and indicates poor clinical outcome in stage I and II disease
por: Helms, M W, et al.
Publicado: (2008)

Emergence of Terbinafine Resistant Trichophyton mentagrophytes in Iran, Harboring Mutations in the Squalene Epoxidase (SQLE) Gene
por: Taghipour, Simin, et al.
Publicado: (2020)

Squalene epoxidase drives cancer cell proliferation and promotes gut dysbiosis to accelerate colorectal carcinogenesis
por: Li, Chuangen, et al.
Publicado: (2022)

Novel Insight into the Role of Squalene Epoxidase (SQLE) Gene in Determining Milk Production Traits in Buffalo
por: Chen, Chao, et al.
Publicado: (2023)

Squalene Epoxidase Correlates E-Cadherin Expression and Overall Survival in Colorectal Cancer Patients: The Impact on Prognosis and Correlation to Clinicopathologic Features
por: Kim, Joo Heon, et al.
Publicado: (2019)

High Squalene Epoxidase in Tumors Predicts Worse Survival in Patients With Hepatocellular Carcinoma: Integrated Bioinformatic Analysis on NAFLD and HCC
por: Shen, Tingting, et al.
Publicado: (2020)

Methyl jasmonate promote protostane triterpenes accumulation by up-regulating the expression of squalene epoxidases in Alisma orientale
por: Tian, Rong, et al.
Publicado: (2019)

Inhibition of squalene epoxidase linking with PI3K/AKT signaling pathway suppresses endometrial cancer
por: Ma, Liangjian, et al.
Publicado: (2023)

Squalene epoxidase plays a critical role in determining pig meat quality by regulating adipogenesis, myogenesis, and ROS scavengers
por: Ha, Jeongim, et al.
Publicado: (2017)

Nt-acetylation-independent turnover of SQUALENE EPOXIDASE 1 by Arabidopsis DOA10-like E3 ligases
por: Etherington, Ross D, et al.
Publicado: (2023)

Squalene epoxidase promotes the proliferation and metastasis of lung squamous cell carcinoma cells though extracellular signal‐regulated kinase signaling
por: Ge, Hong, et al.
Publicado: (2019)

Intrinsic resistance to terbinafine among human and animal isolates of Trichophyton mentagrophytes related to amino acid substitution in the squalene epoxidase
por: Łagowski, Dominik, et al.
Publicado: (2020)

Genome‐Scale CRISPR/Cas9 Screening Reveals Squalene Epoxidase as a Susceptibility Factor for Cytotoxicity of Malformin A1
por: Koizumi, Yukio, et al.
Publicado: (2019)

Squalene epoxidase‐induced cholesteryl ester accumulation promotes nasopharyngeal carcinoma development by activating PI3K/AKT signaling
por: Li, Liming, et al.
Publicado: (2020)

Squalene epoxidase/SQLE is a candidate target for treatment of colorectal cancers with p53 mutation and elevated c-MYC expression
por: Du, Yuyun, et al.
Publicado: (2023)

Point mutations in the squalene epoxidase gene of Indian ITS genotype VIII T. mentagrophytes identified after DNA isolation from infected scales
por: Burmester, Anke, et al.
Publicado: (2019)

A small H(2)O-soluble ingredient of royal jelly lower cholesterol levels in liver cells by suppressing squalene epoxidase
por: Wang, Chi, et al.
Publicado: (2022)

Collagenous Spherulosis Associated with Lobular Carcinoma In Situ of the Breast: Two Case Reports
por: Kim, Ga-Eon, et al.
Publicado: (2018)

Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1‐mediated MAPK signaling
por: He, Luwei, et al.
Publicado: (2021)

Differentially Expressed Genes in Matched Normal, Cancer, and Lymph Node Metastases Predict Clinical Outcomes in Patients With Breast Cancer
por: Kim, Ga-Eon, et al.
Publicado: (2020)

Transcriptome-wide identification of squalene epoxidase genes from Glycyrrhiza glabra L.: expression analysis and heterologous expression of GgSQE1 suggest important role in terpenoid biosynthesis
por: Manzoor, Malik Muzafar, et al.
Publicado: (2021)

High MicroRNA-370 Expression Correlates with Tumor Progression and Poor Prognosis in Breast Cancer
por: Sim, Jongmin, et al.
Publicado: (2015)

Overexpression of prostate tumor overexpressed 1 correlates with tumor progression and predicts poor prognosis in breast cancer
por: Lei, Fangyong, et al.
Publicado: (2014)

Evolution of an atypical de-epoxidase for photoprotection in the green lineage
por: Li, Zhirong, et al.
Publicado: (2016)

C14orf166 overexpression correlates with tumor progression and poor prognosis of breast cancer
por: Cheang, Tuck-yun, et al.
Publicado: (2016)

Overexpression of HDAC9 is associated with poor prognosis and tumor progression of breast cancer in Chinese females
por: Huang, Yixiang, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_08r8n4thugcvhl5rut14ot68o0