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An integrated pan‐cancer analysis of TFAP4 aberrations and the potential clinical implications for cancer immunity
Studies have shown that transcription factor activating enhancer binding protein 4 (TFAP4) plays a vital role in multiple types of cancer; however, the TFAP4 expression profile is still unknown, as is its value within the human pan‐cancer analysis. The present study comprehensively analysed TFAP4 ex...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7882993/ https://www.ncbi.nlm.nih.gov/pubmed/33373169 http://dx.doi.org/10.1111/jcmm.16147 |
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author | Liu, Jian‐Nan Kong, Xiang‐Shuo Sun, Ping Wang, Rui Li, Wang Chen, Qi‐Feng |
author_facet | Liu, Jian‐Nan Kong, Xiang‐Shuo Sun, Ping Wang, Rui Li, Wang Chen, Qi‐Feng |
author_sort | Liu, Jian‐Nan |
collection | PubMed |
description | Studies have shown that transcription factor activating enhancer binding protein 4 (TFAP4) plays a vital role in multiple types of cancer; however, the TFAP4 expression profile is still unknown, as is its value within the human pan‐cancer analysis. The present study comprehensively analysed TFAP4 expression patterns from 33 types of malignancies, along with the significance of TFAP4 for prognosis prediction and cancer immunity. TFAP4 displayed inconsistent levels of gene expression across the diverse cancer cell lines, and displayed abnormal expression within most malignant tumours, which closely corresponded to overall survival. More importantly, the TFAP4 level was also significantly related to the degree of tumour infiltration. TFAP4 was correlated using gene markers in tumour‐infiltrating immune cells and immune scores. TFAP4 expression was correlated with tumour mutation burden and microsatellite instability in different cancer types, and enrichment analyses identified TFAP4‐associated terms and pathways. The present study comprehensively analysed the expression of TFAP4 across 33 distinct types of cancers, which revealed that TFAP4 may possibly play a vital role during cancer formation and development. TFAP4 is related to differing degrees of immune infiltration within cancers, which suggests the potential of TFAP4 as an immunotherapy target in cancers. Our study demonstrated that TFAP4 plays an important role in tumorigenesis as a prognostic biomarker, which highlights the possibility of developing new targeted treatments. |
format | Online Article Text |
id | pubmed-7882993 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78829932021-02-19 An integrated pan‐cancer analysis of TFAP4 aberrations and the potential clinical implications for cancer immunity Liu, Jian‐Nan Kong, Xiang‐Shuo Sun, Ping Wang, Rui Li, Wang Chen, Qi‐Feng J Cell Mol Med Original Articles Studies have shown that transcription factor activating enhancer binding protein 4 (TFAP4) plays a vital role in multiple types of cancer; however, the TFAP4 expression profile is still unknown, as is its value within the human pan‐cancer analysis. The present study comprehensively analysed TFAP4 expression patterns from 33 types of malignancies, along with the significance of TFAP4 for prognosis prediction and cancer immunity. TFAP4 displayed inconsistent levels of gene expression across the diverse cancer cell lines, and displayed abnormal expression within most malignant tumours, which closely corresponded to overall survival. More importantly, the TFAP4 level was also significantly related to the degree of tumour infiltration. TFAP4 was correlated using gene markers in tumour‐infiltrating immune cells and immune scores. TFAP4 expression was correlated with tumour mutation burden and microsatellite instability in different cancer types, and enrichment analyses identified TFAP4‐associated terms and pathways. The present study comprehensively analysed the expression of TFAP4 across 33 distinct types of cancers, which revealed that TFAP4 may possibly play a vital role during cancer formation and development. TFAP4 is related to differing degrees of immune infiltration within cancers, which suggests the potential of TFAP4 as an immunotherapy target in cancers. Our study demonstrated that TFAP4 plays an important role in tumorigenesis as a prognostic biomarker, which highlights the possibility of developing new targeted treatments. John Wiley and Sons Inc. 2020-12-29 2021-02 /pmc/articles/PMC7882993/ /pubmed/33373169 http://dx.doi.org/10.1111/jcmm.16147 Text en © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Liu, Jian‐Nan Kong, Xiang‐Shuo Sun, Ping Wang, Rui Li, Wang Chen, Qi‐Feng An integrated pan‐cancer analysis of TFAP4 aberrations and the potential clinical implications for cancer immunity |
title | An integrated pan‐cancer analysis of TFAP4 aberrations and the potential clinical implications for cancer immunity |
title_full | An integrated pan‐cancer analysis of TFAP4 aberrations and the potential clinical implications for cancer immunity |
title_fullStr | An integrated pan‐cancer analysis of TFAP4 aberrations and the potential clinical implications for cancer immunity |
title_full_unstemmed | An integrated pan‐cancer analysis of TFAP4 aberrations and the potential clinical implications for cancer immunity |
title_short | An integrated pan‐cancer analysis of TFAP4 aberrations and the potential clinical implications for cancer immunity |
title_sort | integrated pan‐cancer analysis of tfap4 aberrations and the potential clinical implications for cancer immunity |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7882993/ https://www.ncbi.nlm.nih.gov/pubmed/33373169 http://dx.doi.org/10.1111/jcmm.16147 |
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