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Thalidomide and its metabolite 5‐hydroxythalidomide induce teratogenicity via the cereblon neosubstrate PLZF

Thalidomide causes teratogenic effects by inducing protein degradation via cereblon (CRBN)‐containing ubiquitin ligase and modification of its substrate specificity. Human P450 cytochromes convert thalidomide into two monohydroxylated metabolites that are considered to contribute to thalidomide effe...

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Detalles Bibliográficos
Autores principales:	Yamanaka, Satoshi, Murai, Hidetaka, Saito, Daisuke, Abe, Gembu, Tokunaga, Etsuko, Iwasaki, Takahiro, Takahashi, Hirotaka, Takeda, Hiroyuki, Suzuki, Takayuki, Shibata, Norio, Tamura, Koji, Sawasaki, Tatsuya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883055/ https://www.ncbi.nlm.nih.gov/pubmed/33470442 http://dx.doi.org/10.15252/embj.2020105375

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