Cargando…

Thalidomide and its metabolite 5‐hydroxythalidomide induce teratogenicity via the cereblon neosubstrate PLZF

Thalidomide causes teratogenic effects by inducing protein degradation via cereblon (CRBN)‐containing ubiquitin ligase and modification of its substrate specificity. Human P450 cytochromes convert thalidomide into two monohydroxylated metabolites that are considered to contribute to thalidomide effe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yamanaka, Satoshi, Murai, Hidetaka, Saito, Daisuke, Abe, Gembu, Tokunaga, Etsuko, Iwasaki, Takahiro, Takahashi, Hirotaka, Takeda, Hiroyuki, Suzuki, Takayuki, Shibata, Norio, Tamura, Koji, Sawasaki, Tatsuya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883055/ https://www.ncbi.nlm.nih.gov/pubmed/33470442 http://dx.doi.org/10.15252/embj.2020105375

Ejemplares similares

Structural basis of thalidomide enantiomer binding to cereblon
por: Mori, Tomoyuki, et al.
Publicado: (2018)

PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates
por: Shimizu, Nobuyuki, et al.
Publicado: (2021)

Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide
por: Furihata, Hirotake, et al.
Publicado: (2020)

Lenalidomide derivatives and proteolysis-targeting chimeras for controlling neosubstrate degradation
por: Yamanaka, Satoshi, et al.
Publicado: (2023)

Molecular Mechanisms of the Teratogenic Effects of Thalidomide
por: Asatsuma-Okumura, Tomoko, et al.
Publicado: (2020)

Understanding the Thalidomide Chirality in Biological Processes by the Self-disproportionation of Enantiomers
por: Tokunaga, Etsuko, et al.
Publicado: (2018)

The Neuroprotective Effect of Thalidomide against Ischemia through the Cereblon-mediated Repression of AMPK Activity
por: Sawamura, Naoya, et al.
Publicado: (2018)

Nitric oxide rescues thalidomide mediated teratogenicity
por: Siamwala, Jamila H., et al.
Publicado: (2012)

CRL4-Cereblon complex in Thalidomide Embryopathy: a translational investigation
por: Kowalski, Thayne Woycinck, et al.
Publicado: (2020)

Antiangiogenic Activity and in Silico Cereblon Binding Analysis of Novel Thalidomide Analogs
por: Peach, Megan L., et al.
Publicado: (2020)

Biological evaluation of both enantiomers of fluoro-thalidomide using human myeloma cell line H929 and others
por: Tokunaga, Etsuko, et al.
Publicado: (2017)

De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide Derivatives
por: Heim, Christopher, et al.
Publicado: (2019)

Evaluation of the influence of genetic variants in Cereblon gene on the response to the treatment of erythema nodosum leprosum with thalidomide
por: Costa, Perpétua do Socorro Silva, et al.
Publicado: (2022)

Novel, thalidomide-like, non-cereblon binding drug tetrafluorobornylphthalimide mitigates inflammation and brain injury
por: Lecca, Daniela, et al.
Publicado: (2023)

Profiling the Landscape of Drug Resistance Mutations in Neosubstrates to Molecular Glue Degraders
por: Gosavi, Pallavi M., et al.
Publicado: (2022)

The Thalidomide-Binding Domain of Cereblon Defines the CULT Domain Family and Is a New Member of the β-Tent Fold
por: Lupas, Andrei N., et al.
Publicado: (2015)

Self-disproportionation of enantiomers of thalidomide and its fluorinated analogue via gravity-driven achiral chromatography: mechanistic rationale and implications
por: Maeno, Mayaka, et al.
Publicado: (2015)

Esco2 and cohesin regulate CRL4 ubiquitin ligase ddb1 expression and thalidomide teratogenicity
por: Sanchez, Annie C., et al.
Publicado: (2022)

Augmentation of Pectoral Fin Teratogenicity by Thalidomide in Human Cytochrome P450 3A-Expressing Zebrafish
por: Dong, Wenjing, et al.
Publicado: (2023)

In silico analysis of enantioselective binding of immunomodulatory imide drugs to cereblon
por: Murai, Takahiro, et al.
Publicado: (2016)

Shape-shifting and tumor suppression by PLZF
por: Hobbs, Robin M., et al.
Publicado: (2010)

Chemical Ligand Space of Cereblon
por: Boichenko, Iuliia, et al.
Publicado: (2018)

Expression of cereblon protein assessed by immunohistochemicalstaining in myeloma cells is associated with superior response of thalidomide- and lenalidomide-based treatment, but not bortezomib-based treatment, in patients with multiple myeloma
por: Huang, Shang-Yi, et al.
Publicado: (2014)

Design, Synthesis, and Biological Evaluation of New Potential Unusual Modified Anticancer Immunomodulators for Possible Non-Teratogenic Quinazoline-Based Thalidomide Analogs
por: Mabrouk, Reda R., et al.
Publicado: (2023)

Teratogenicity and hyperprolactinemia
por: Andrade, Chittaranjan
Publicado: (2009)

Teratogenicity with Olanzapine
por: Prakash, Sathya, et al.
Publicado: (2014)

A proximity biotinylation-based approach to identify protein-E3 ligase interactions induced by PROTACs and molecular glues
por: Yamanaka, Satoshi, et al.
Publicado: (2022)

Mouse Monoclonal Antibodies Generated from Full Length Human Cereblon: Detection of Cereblon Protein in Patients with Multiple Myeloma
por: Chang, Xiubao, et al.
Publicado: (2017)

Characterisation of Genome-Wide PLZF/RARA Target Genes
por: Spicuglia, Salvatore, et al.
Publicado: (2011)

Role of PLZF as a tumor suppressor in prostate cancer
por: Jin, Yang, et al.
Publicado: (2017)

Structural Dynamics of the Cereblon Ligand Binding Domain
por: Hartmann, Marcus D., et al.
Publicado: (2015)

Tubulin Resists Degradation by Cereblon-Recruiting PROTACs
por: Gasic, Ivana, et al.
Publicado: (2020)

UDP-glucose, cereblon-dependent proinsulin degrader
por: Cho, Jaeyong, et al.
Publicado: (2022)

Catalog of Teratogenic Agents
por: Craig, A. W.
Publicado: (1974)

Catalog of Teratogenic Agents
por: Craig, A. W.
Publicado: (1980)

Catalog of Teratogenic Agents
por: Craig, A. W.
Publicado: (1977)

Teratogenicity of Antiepileptic Drugs
por: Güveli, Betül Tekin, et al.
Publicado: (2017)

Teratogenicity and Antiseizure Medications
por: Meador, Kimford
Publicado: (2020)

Teratogenicity of D-allulose
por: Sa, Soonok, et al.
Publicado: (2022)

An allele separating skeletal patterning and spermatogonial renewal functions of PLZF
por: Ching, Yung-Hao, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_4f66a7m4aisiihsjhugpb4h5mf