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Pharmacokinetics of exogenous GIP(1-42) in C57Bl/6 mice; Extremely rapid degradation but marked variation between available assays

Like other peptide hormones, glucose-dependent insulinotropic polypeptide (GIP) is rapidly cleared from the circulation. Dipeptidyl peptidase-4 (DPP-4) is known to be involved. Information on the overall pharmacokinetics of GIP in rodents is, however, lacking. We investigated the pharmacokinetics of...

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Detalles Bibliográficos
Autores principales:	Boer, Geke Aline, Hartmann, Bolette, Holst, Jens Juul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Science Inc 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883216/ https://www.ncbi.nlm.nih.gov/pubmed/33245951 http://dx.doi.org/10.1016/j.peptides.2020.170457

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