Cargando…

Mitochondria-targeted magnolol inhibits OXPHOS, proliferation, and tumor growth via modulation of energetics and autophagy in melanoma cells

INTRODUCTION: Melanoma is an aggressive form of skin cancer for which there are no effective drugs for prolonged treatment. The existing kinase inhibitor antiglycolytic drugs (B-Raf serine/threonine kinase or BRAF inhibitors) are effective for a short time followed by a rapid onset of drug resistanc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheng, Gang, Hardy, Micael, Zielonka, Jacek, Weh, Katherine, Zielonka, Monika, Boyle, Kathleen A., Abu Eid, Mahmoud, McAllister, Donna, Bennett, Brian, Kresty, Laura A., Dwinell, Michael B., Kalyanaraman, Balaraman
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883397/ https://www.ncbi.nlm.nih.gov/pubmed/32987287 http://dx.doi.org/10.1016/j.ctarc.2020.100210

Ejemplares similares

Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis
por: Cheng, Gang, et al.
Publicado: (2019)

Mitochondria-targeted vitamin E analogs inhibit breast cancer cell energy metabolism and promote cell death
por: Cheng, Gang, et al.
Publicado: (2013)

A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds
por: Kalyanaraman, Balaraman, et al.
Publicado: (2017)

Corrigendum to 'A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds' [REDOX 14C (2017) 316–327]
por: Kalyanaraman, Balaraman, et al.
Publicado: (2018)

Mitochondria-targeted hydroxyurea inhibits OXPHOS and induces antiproliferative and immunomodulatory effects
por: Cheng, Gang, et al.
Publicado: (2021)

Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression
por: AbuEid, Mahmoud, et al.
Publicado: (2021)

Synergistic inhibition of tumor cell proliferation by metformin and mito-metformin in the presence of iron chelators
por: Cheng, Gang, et al.
Publicado: (2019)

Teaching the basics of reactive oxygen species and their relevance to cancer biology: Mitochondrial reactive oxygen species detection, redox signaling, and targeted therapies
por: Kalyanaraman, Balaraman, et al.
Publicado: (2017)

Green fluorescent proteins induce oxidative stress in cells: A worrisome new wrinkle in the application of the GFP reporter system to biological systems?
por: Kalyanaraman, Balaraman, et al.
Publicado: (2017)

Profiling and targeting of cellular bioenergetics: inhibition of pancreatic cancer cell proliferation
por: Cheng, G, et al.
Publicado: (2014)

Antiproliferative effects of mitochondria-targeted N-acetylcysteine and analogs in cancer cells
por: Cheng, Gang, et al.
Publicado: (2023)

Mitochondria-targeted paraquat and metformin mediate ROS production to induce multiple pathways of retrograde signaling: A dose-dependent phenomenon
por: Chowdhury, Anindya Roy, et al.
Publicado: (2020)

Mitochondria-Targeted Honokiol Confers a Striking Inhibitory Effect on Lung Cancer via Inhibiting Complex I Activity
por: Pan, Jing, et al.
Publicado: (2018)

Chemoprevention of Lung Cancer with a Combination of Mitochondria-Targeted Compounds
por: Zhang, Qi, et al.
Publicado: (2022)

Potent inhibition of tumour cell proliferation and immunoregulatory function by mitochondria-targeted atovaquone
por: Cheng, Gang, et al.
Publicado: (2020)

Oxidation of ethidium-based probes by biological radicals: mechanism, kinetics and implications for the detection of superoxide
por: Michalski, Radosław, et al.
Publicado: (2020)

Therapeutic Targeting of Tumor Cells and Tumor Immune Microenvironment Vulnerabilities
por: Kalyanaraman, Balaraman, et al.
Publicado: (2022)

Combining PEGylated mito-atovaquone with MCT and Krebs cycle redox inhibitors as a potential strategy to abrogate tumor cell proliferation
por: Cheng, Gang, et al.
Publicado: (2022)

Polyphenolic Boronates Inhibit Tumor Cell Proliferation: Potential Mitigators of Oxidants in the Tumor Microenvironment
por: Cheng, Gang, et al.
Publicado: (2023)

Prevention of Tumor Growth and Dissemination by In Situ Vaccination with Mitochondria‐Targeted Atovaquone
por: Huang, Mofei, et al.
Publicado: (2022)

Teaching the basics of repurposing mitochondria-targeted drugs: From Parkinson's disease to cancer and back to Parkinson's disease
por: Kalyanaraman, Balaraman
Publicado: (2020)

The Chemistry of HNO: Mechanisms and Reaction Kinetics
por: Michalski, Radosław, et al.
Publicado: (2022)

Mitochondria, Energetics, Epigenetics, and Cellular Responses to Stress
por: Shaughnessy, Daniel T., et al.
Publicado: (2014)

Exploiting the tumor immune microenvironment and immunometabolism using mitochondria‐targeted drugs: Challenges and opportunities in racial disparity and cancer outcome research
por: Kalyanaraman, Balaraman
Publicado: (2022)

Boronate-Based Probes for Biological Oxidants: A Novel Class of Molecular Tools for Redox Biology
por: Sikora, Adam, et al.
Publicado: (2020)

OXPHOS Organization and Activity in Mitochondria of Plants with Different Life Strategies
por: Ukolova, Irina V., et al.
Publicado: (2023)

Bezielle Selectively Targets Mitochondria of Cancer Cells to Inhibit Glycolysis and OXPHOS
por: Chen, Vivian, et al.
Publicado: (2012)

Mechanical instability generated by Myosin 19 contributes to mitochondria cristae architecture and OXPHOS
por: Shi, Peng, et al.
Publicado: (2022)

Cranberries and Cancer: An Update of Preclinical Studies Evaluating the Cancer Inhibitory Potential of Cranberry and Cranberry Derived Constituents
por: Weh, Katherine M., et al.
Publicado: (2016)

2543 High concentrations of CXCL12 decrease pancreatic adenocarcinoma growth
por: Vonderhaar, Emily, et al.
Publicado: (2018)

Accumulation of damaged mitochondria in alveolar macrophages with reduced OXPHOS related gene expression in IPF
por: Tsitoura, Eliza, et al.
Publicado: (2019)

Autophagy triggered by magnolol derivative negatively regulates angiogenesis
por: Kumar, S, et al.
Publicado: (2013)

Magnolia extract is effective for the chemoprevention of oral cancer through its ability to inhibit mitochondrial respiration at complex I
por: Zhang, Qi, et al.
Publicado: (2020)

Cranberry proanthocyanidins modulate reactive oxygen species in Barrett’s and esophageal adenocarcinoma cell lines
por: Weh, Katherine M., et al.
Publicado: (2016)

Synthesis of fluorinated triphenylphosphonium analogs that improve cancer cell selectivity and in vivo detection
por: Keyes, Robert F., et al.
Publicado: (2023)

Insights on the Multifunctional Activities of Magnolol
por: Zhang, Jianhong, et al.
Publicado: (2019)

Mitochondria and Energetic Depression in Cell Pathophysiology
por: Seppet, Enn, et al.
Publicado: (2009)

An energetic view of stress: Focus on mitochondria
por: Picard, Martin, et al.
Publicado: (2018)

STING Activated Tumor-Intrinsic Type I Interferon Signaling Promotes CXCR3 Dependent Antitumor Immunity in Pancreatic Cancer
por: Vonderhaar, Emily P., et al.
Publicado: (2021)

Fluorinated triphenylphosphonium analogs improve cell selectivity and in vivo detection of mito-metformin
por: AbuEid, Mahmoud, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_jf6a3gmv353m3h3ejapsuf3j7g