Silencing of Vangl2 attenuates the inflammation promoted by Wnt5a via MAPK and NF-κB pathway in chondrocytes

BACKGROUND: The Wnt planar cell polarity (PCP) pathway is implicated in osteoarthritis (OA) both in animals and in humans. Van Gogh-like 2 (Vangl2) is a key PCP protein that is required for the orientation and alignment of chondrocytes in the growth plate. However, its functional roles in OA still r...

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Detalles Bibliográficos
Autores principales: Zhang, Ke, Li, Zhuoying, Lu, Yunyang, Xiang, Linyi, Sun, Jiadong, Zhang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883434/
https://www.ncbi.nlm.nih.gov/pubmed/33588909
http://dx.doi.org/10.1186/s13018-021-02268-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883434/
https://www.ncbi.nlm.nih.gov/pubmed/33588909
http://dx.doi.org/10.1186/s13018-021-02268-x

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