Cargando…

Silencing of Vangl2 attenuates the inflammation promoted by Wnt5a via MAPK and NF-κB pathway in chondrocytes

BACKGROUND: The Wnt planar cell polarity (PCP) pathway is implicated in osteoarthritis (OA) both in animals and in humans. Van Gogh-like 2 (Vangl2) is a key PCP protein that is required for the orientation and alignment of chondrocytes in the growth plate. However, its functional roles in OA still r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Ke, Li, Zhuoying, Lu, Yunyang, Xiang, Linyi, Sun, Jiadong, Zhang, Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883434/ https://www.ncbi.nlm.nih.gov/pubmed/33588909 http://dx.doi.org/10.1186/s13018-021-02268-x

Ejemplares similares

Cepharanthine Ameliorates Chondrocytic Inflammation and Osteoarthritis via Regulating the MAPK/NF-κB-Autophagy Pathway
por: Yao, Minjun, et al.
Publicado: (2022)

α-Cyperone (CYP) down-regulates NF-κB and MAPKs signaling, attenuating inflammation and extracellular matrix degradation in chondrocytes, to ameliorate osteoarthritis in mice
por: Zhang, Huawei, et al.
Publicado: (2021)

Kinsenoside attenuates osteoarthritis by repolarizing macrophages through inactivating NF-κB/MAPK signaling and protecting chondrocytes
por: Zhou, Feng, et al.
Publicado: (2019)

Curcumenol mitigates chondrocyte inflammation by inhibiting the NF-κB and MAPK pathways, and ameliorates DMM-induced OA in mice
por: Yang, Xiao, et al.
Publicado: (2021)

Schisandrin B ameliorated chondrocytes inflammation and osteoarthritis via suppression of NF-κB and MAPK signal pathways
por: Ran, Jisheng, et al.
Publicado: (2018)

Naringenin attenuates inflammation and apoptosis of osteoarthritic chondrocytes via the TLR4/TRAF6/NF-κB pathway
por: Wang, Yan, et al.
Publicado: (2023)

Artemisia gmelinii Attenuates Lung Inflammation by Suppressing the NF-κB/MAPK Pathway
por: Kim, Seung Yong, et al.
Publicado: (2022)

Engeletin Alleviates the Inflammation and Apoptosis in Intervertebral Disc Degeneration via Inhibiting the NF-κB and MAPK Pathways
por: Li, Baixing, et al.
Publicado: (2022)

(+)-JQ1 attenuated LPS-induced microglial inflammation via MAPK/NFκB signaling
por: Wang, Huanhuan, et al.
Publicado: (2018)

Carbon dots derived from folic acid attenuates osteoarthritis by protecting chondrocytes through NF-κB/MAPK pathway and reprogramming macrophages
por: Jin, Yu, et al.
Publicado: (2022)

Molecular Characterisation of Endogenous Vangl2/Vangl1 Heteromeric Protein Complexes
por: Belotti, Edwige, et al.
Publicado: (2012)

Ononin ameliorates inflammation and cartilage degradation in rat chondrocytes with IL-1β-induced osteoarthritis by downregulating the MAPK and NF-κB pathways
por: Xu, Fang, et al.
Publicado: (2022)

MiR-19b-3p Attenuates Chondrocytes Injury by Inhibiting MAPK/NF-Κb Axis via Targeting SOCS1
por: Shi, Liang, et al.
Publicado: (2022)

Vangl as a Master Scaffold for Wnt/Planar Cell Polarity Signaling in Development and Disease
por: Dreyer, Courtney A., et al.
Publicado: (2022)

Retracted: MiR-19b-3p Attenuates Chondrocytes Injury by Inhibiting MAPK/NF-Κb Axis via Targeting SOCS1
por: and Alternative Medicine, Evidence-Based Complementary
Publicado: (2023)

Nobiletin Inhibits IL-1β-Induced Inflammation in Chondrocytes via Suppression of NF-κB Signaling and Attenuates Osteoarthritis in Mice
por: Lin, Zeng, et al.
Publicado: (2019)

Planar polarization of Vangl2 in the vertebrate neural plate is controlled by Wnt and Myosin II signaling
por: Ossipova, Olga, et al.
Publicado: (2015)

Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling
por: Brunt, Lucy, et al.
Publicado: (2021)

PRMT5 inhibition attenuates cartilage degradation by reducing MAPK and NF-κB signaling
por: Dong, Yonghui, et al.
Publicado: (2020)

Bisdemethoxycurcumin attenuates OVA-induced food allergy by inhibiting the MAPK and NF-κB signaling pathways
por: Wang, Yanjie, et al.
Publicado: (2022)

Schisandrin A Inhibits the IL-1β-Induced Inflammation and Cartilage Degradation via Suppression of MAPK and NF-κB Signal Pathways in Rat Chondrocytes
por: Tu, Chang, et al.
Publicado: (2019)

Roxatidine attenuates mast cell-mediated allergic inflammation via inhibition of NF-κB and p38 MAPK activation
por: Lee, Minho, et al.
Publicado: (2017)

Tanreqing Injection Attenuates Lipopolysaccharide-Induced Airway Inflammation through MAPK/NF-κB Signaling Pathways in Rats Model
por: Liu, Wei, et al.
Publicado: (2016)

USP7 Attenuates Endoplasmic Reticulum Stress and NF-κB Signaling to Modulate Chondrocyte Proliferation, Apoptosis, and Inflammatory Response under Inflammation
por: Dong, Xiaofei, et al.
Publicado: (2022)

Phillygenin inhibits inflammation in chondrocytes via the Nrf2/NF-κB axis and ameliorates osteoarthritis in mice
por: Zhang, Peng, et al.
Publicado: (2023)

Silencing NUDT21 Attenuates the Mesenchymal Identity of Glioblastoma Cells via the NF-κB Pathway
por: Lou, Jia-Cheng, et al.
Publicado: (2017)

Baicalin Relieves LPS-Induced Lung Inflammation via the NF-κB and MAPK Pathways
por: Shen, Bingyu, et al.
Publicado: (2023)

Angelica polysaccharide attenuates LPS-induced inflammation response of primary dairy cow claw dermal cells via NF-κB and MAPK signaling pathways
por: Tian, Mengyue, et al.
Publicado: (2021)

Vindoline Attenuates Osteoarthritis Progression Through Suppressing the NF-κB and ERK Pathways in Both Chondrocytes and Subchondral Osteoclasts
por: Zhu, Meisong, et al.
Publicado: (2022)

Urolithin a attenuates IL-1β-induced inflammatory responses and cartilage degradation via inhibiting the MAPK/NF-κB signaling pathways in rat articular chondrocytes
por: Ding, Sheng-long, et al.
Publicado: (2020)

Brilliant blue G attenuates neuro-inflammation via regulating MAPKs and NF-κB signaling pathways in lipopolysaccharide-induced BV2 microglia cells
por: Wang, Wei, et al.
Publicado: (2020)

Luo Tong formula attenuates retinal inflammation in diabetic rats via inhibition of the p38MAPK/NF-κB pathway
por: Pang, Bing, et al.
Publicado: (2020)

Corilagin ameliorates macrophages inflammation in atherosclerosis through TLR4-NFκB/MAPK pathway
por: Meng, Da, et al.
Publicado: (2023)

Icariin inhibits the inflammation through down-regulating NF-κB/HIF-2α signal pathways in chondrocytes
por: Wang, Pengzhen, et al.
Publicado: (2020)

Morusin Ameliorates IL-1β-Induced Chondrocyte Inflammation and Osteoarthritis via NF-κB Signal Pathway
por: Jia, Yewei, et al.
Publicado: (2020)

Fxyd5 activates the NF-κB pathway and is involved in chondrocytes inflammation and extracellular matrix degradation
por: Song, Lulu, et al.
Publicado: (2022)

Discovery of Novel Pterostilbene Derivatives That Might Treat Sepsis by Attenuating Oxidative Stress and Inflammation through Modulation of MAPKs/NF-κB Signaling Pathways
por: Fang, Mengyuan, et al.
Publicado: (2021)

Loganin attenuates interleukin-1β-induced chondrocyte inflammation, cartilage degeneration, and rat synovial inflammation by regulating TLR4/MyD88/NF-κB
por: Wan, Haishan, et al.
Publicado: (2022)

Vangl-dependent Wnt/planar cell polarity signaling mediates collective breast carcinoma motility and distant metastasis
por: VanderVorst, Kacey, et al.
Publicado: (2023)

Paroxetine Attenuates Chondrocyte Pyroptosis and Inhibits Osteoclast Formation by Inhibiting NF-κB Pathway Activation to Delay Osteoarthritis Progression
por: Zheng, Xiaohang, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_f3qu14uic0r9of1fi0epu386os