Increase of aerobic glycolysis mediated by activated T helper cells drives synovial fibroblasts towards an inflammatory phenotype: new targets for therapy?

BACKGROUND: A dysregulated glucose metabolism in synovial fibroblasts (SF) has been associated with their aggressive phenotype in rheumatoid arthritis (RA). Even though T helper (Th) cells are key effector cells in the propagation and exacerbation of synovitis in RA, little is known about their infl...

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Detalles Bibliográficos
Autores principales: Kvacskay, Peter, Yao, Nina, Schnotz, Jürgen-Heinz, Scarpone, Roberta, Carvalho, Rui de Albuquerque, Klika, Karel D., Merkt, Wolfgang, Tretter, Theresa, Lorenz, Hanns-Martin, Tykocinski, Lars-Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883459/
https://www.ncbi.nlm.nih.gov/pubmed/33588937
http://dx.doi.org/10.1186/s13075-021-02437-7

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