Cargando…

Potential Mechanisms and Effects of Efferocytosis in Atherosclerosis

Atherosclerosis (AS) is the main pathological basis for the development of cardio-cerebrovascular diseases. Abnormal accumulation of apoptotic and necrotic cells resulted in plaque enlargement, necrotic core formation and plaque rupture in AS. Under physiological conditions, apoptotic cells (ACs) co...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Lili, Li, Hongxia, Tang, Yuhan, Yao, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883484/
https://www.ncbi.nlm.nih.gov/pubmed/33597922
http://dx.doi.org/10.3389/fendo.2020.585285
_version_ 1783651217961910272
author Wang, Lili
Li, Hongxia
Tang, Yuhan
Yao, Ping
author_facet Wang, Lili
Li, Hongxia
Tang, Yuhan
Yao, Ping
author_sort Wang, Lili
collection PubMed
description Atherosclerosis (AS) is the main pathological basis for the development of cardio-cerebrovascular diseases. Abnormal accumulation of apoptotic and necrotic cells resulted in plaque enlargement, necrotic core formation and plaque rupture in AS. Under physiological conditions, apoptotic cells (ACs) could be effectively phagocytized and cleared by phagocyte-mediated efferocytosis. In contrast, the clearance efficiency of ACs in AS plaque was much lower because of the impaired efferocytosis in AS. Recent findings have made great progress on the molecular mechanisms of efferocytosis process and dynamic regulation, and its dysfunction on organismal health. Yet, there are still few effective treatments for this process. This article reviews the mechanism of efferocytosis and the role of efferocytosis in AS, highlighting a novel therapeutic strategy for AS, which mainly prevents the progression of plaque by targeting efferocytosis.
format Online
Article
Text
id pubmed-7883484
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-78834842021-02-16 Potential Mechanisms and Effects of Efferocytosis in Atherosclerosis Wang, Lili Li, Hongxia Tang, Yuhan Yao, Ping Front Endocrinol (Lausanne) Endocrinology Atherosclerosis (AS) is the main pathological basis for the development of cardio-cerebrovascular diseases. Abnormal accumulation of apoptotic and necrotic cells resulted in plaque enlargement, necrotic core formation and plaque rupture in AS. Under physiological conditions, apoptotic cells (ACs) could be effectively phagocytized and cleared by phagocyte-mediated efferocytosis. In contrast, the clearance efficiency of ACs in AS plaque was much lower because of the impaired efferocytosis in AS. Recent findings have made great progress on the molecular mechanisms of efferocytosis process and dynamic regulation, and its dysfunction on organismal health. Yet, there are still few effective treatments for this process. This article reviews the mechanism of efferocytosis and the role of efferocytosis in AS, highlighting a novel therapeutic strategy for AS, which mainly prevents the progression of plaque by targeting efferocytosis. Frontiers Media S.A. 2021-02-01 /pmc/articles/PMC7883484/ /pubmed/33597922 http://dx.doi.org/10.3389/fendo.2020.585285 Text en Copyright © 2021 Wang, Li, Tang and Yao http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Wang, Lili
Li, Hongxia
Tang, Yuhan
Yao, Ping
Potential Mechanisms and Effects of Efferocytosis in Atherosclerosis
title Potential Mechanisms and Effects of Efferocytosis in Atherosclerosis
title_full Potential Mechanisms and Effects of Efferocytosis in Atherosclerosis
title_fullStr Potential Mechanisms and Effects of Efferocytosis in Atherosclerosis
title_full_unstemmed Potential Mechanisms and Effects of Efferocytosis in Atherosclerosis
title_short Potential Mechanisms and Effects of Efferocytosis in Atherosclerosis
title_sort potential mechanisms and effects of efferocytosis in atherosclerosis
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883484/
https://www.ncbi.nlm.nih.gov/pubmed/33597922
http://dx.doi.org/10.3389/fendo.2020.585285
work_keys_str_mv AT wanglili potentialmechanismsandeffectsofefferocytosisinatherosclerosis
AT lihongxia potentialmechanismsandeffectsofefferocytosisinatherosclerosis
AT tangyuhan potentialmechanismsandeffectsofefferocytosisinatherosclerosis
AT yaoping potentialmechanismsandeffectsofefferocytosisinatherosclerosis