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Potential Mechanisms and Effects of Efferocytosis in Atherosclerosis
Atherosclerosis (AS) is the main pathological basis for the development of cardio-cerebrovascular diseases. Abnormal accumulation of apoptotic and necrotic cells resulted in plaque enlargement, necrotic core formation and plaque rupture in AS. Under physiological conditions, apoptotic cells (ACs) co...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883484/ https://www.ncbi.nlm.nih.gov/pubmed/33597922 http://dx.doi.org/10.3389/fendo.2020.585285 |
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author | Wang, Lili Li, Hongxia Tang, Yuhan Yao, Ping |
author_facet | Wang, Lili Li, Hongxia Tang, Yuhan Yao, Ping |
author_sort | Wang, Lili |
collection | PubMed |
description | Atherosclerosis (AS) is the main pathological basis for the development of cardio-cerebrovascular diseases. Abnormal accumulation of apoptotic and necrotic cells resulted in plaque enlargement, necrotic core formation and plaque rupture in AS. Under physiological conditions, apoptotic cells (ACs) could be effectively phagocytized and cleared by phagocyte-mediated efferocytosis. In contrast, the clearance efficiency of ACs in AS plaque was much lower because of the impaired efferocytosis in AS. Recent findings have made great progress on the molecular mechanisms of efferocytosis process and dynamic regulation, and its dysfunction on organismal health. Yet, there are still few effective treatments for this process. This article reviews the mechanism of efferocytosis and the role of efferocytosis in AS, highlighting a novel therapeutic strategy for AS, which mainly prevents the progression of plaque by targeting efferocytosis. |
format | Online Article Text |
id | pubmed-7883484 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78834842021-02-16 Potential Mechanisms and Effects of Efferocytosis in Atherosclerosis Wang, Lili Li, Hongxia Tang, Yuhan Yao, Ping Front Endocrinol (Lausanne) Endocrinology Atherosclerosis (AS) is the main pathological basis for the development of cardio-cerebrovascular diseases. Abnormal accumulation of apoptotic and necrotic cells resulted in plaque enlargement, necrotic core formation and plaque rupture in AS. Under physiological conditions, apoptotic cells (ACs) could be effectively phagocytized and cleared by phagocyte-mediated efferocytosis. In contrast, the clearance efficiency of ACs in AS plaque was much lower because of the impaired efferocytosis in AS. Recent findings have made great progress on the molecular mechanisms of efferocytosis process and dynamic regulation, and its dysfunction on organismal health. Yet, there are still few effective treatments for this process. This article reviews the mechanism of efferocytosis and the role of efferocytosis in AS, highlighting a novel therapeutic strategy for AS, which mainly prevents the progression of plaque by targeting efferocytosis. Frontiers Media S.A. 2021-02-01 /pmc/articles/PMC7883484/ /pubmed/33597922 http://dx.doi.org/10.3389/fendo.2020.585285 Text en Copyright © 2021 Wang, Li, Tang and Yao http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Wang, Lili Li, Hongxia Tang, Yuhan Yao, Ping Potential Mechanisms and Effects of Efferocytosis in Atherosclerosis |
title | Potential Mechanisms and Effects of Efferocytosis in Atherosclerosis |
title_full | Potential Mechanisms and Effects of Efferocytosis in Atherosclerosis |
title_fullStr | Potential Mechanisms and Effects of Efferocytosis in Atherosclerosis |
title_full_unstemmed | Potential Mechanisms and Effects of Efferocytosis in Atherosclerosis |
title_short | Potential Mechanisms and Effects of Efferocytosis in Atherosclerosis |
title_sort | potential mechanisms and effects of efferocytosis in atherosclerosis |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883484/ https://www.ncbi.nlm.nih.gov/pubmed/33597922 http://dx.doi.org/10.3389/fendo.2020.585285 |
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