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A Clinical Case of Polymyositis Complicated by Antisynthetase Syndrome
Antisynthetase syndrome is an autoimmune condition that manifests clinically through signs and symptoms, such as interstitial lung disease, myositis, Raynaud’s phenomenon, fever, hyperkeratotic fingertips (mechanic’s hands), and arthritis. It is associated with antibodies against aminoacyl tRNA synt...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Cureus
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883527/ https://www.ncbi.nlm.nih.gov/pubmed/33614339 http://dx.doi.org/10.7759/cureus.12737 |
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author | Khan, Aadil M Ahmad, Faim Rehman, Usama Jindal, Himanshu Harimohan, Hridya |
author_facet | Khan, Aadil M Ahmad, Faim Rehman, Usama Jindal, Himanshu Harimohan, Hridya |
author_sort | Khan, Aadil M |
collection | PubMed |
description | Antisynthetase syndrome is an autoimmune condition that manifests clinically through signs and symptoms, such as interstitial lung disease, myositis, Raynaud’s phenomenon, fever, hyperkeratotic fingertips (mechanic’s hands), and arthritis. It is associated with antibodies against aminoacyl tRNA synthetase enzyme, the most common autoantibody being the anti-Jo-1. An 18-year-old girl presented with weakness of both the upper and lower limb, swelling and generalized body pain, difficulty in swallowing. MRI of the thigh was highly suggestive of myositis with symmetrical bilateral involvement. Based on proximal muscle weakness, elevated creatine phosphokinase (CPK), and lactate dehydrogenase (LDH), strongly positive anti-nuclear antibodies human epithelial cell type-2 (ANA-HEp2), and a normal nerve conduction velocity test with precise MRI findings, a diagnosis of polymyositis was made. She was given bolus intravenous methylprednisolone for five days, followed by oral methylprednisolone with subcutaneous methotrexate weekly. She reported a 50% improvement in muscle weakness; however, partial bulbar weakness persisted at the time of discharge. On her next follow-up, her blood investigations for auto-antibodies were done. The autoantibodies anti-Jo-1 (3+), Ro-52 (2+), and Mi-2β (2+) were found to be positive. These investigations, coupled with the clinical features she was presenting, finally led us to conclude that it was a case of polymyositis complicated by the antisynthetase syndrome. |
format | Online Article Text |
id | pubmed-7883527 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-78835272021-02-18 A Clinical Case of Polymyositis Complicated by Antisynthetase Syndrome Khan, Aadil M Ahmad, Faim Rehman, Usama Jindal, Himanshu Harimohan, Hridya Cureus Internal Medicine Antisynthetase syndrome is an autoimmune condition that manifests clinically through signs and symptoms, such as interstitial lung disease, myositis, Raynaud’s phenomenon, fever, hyperkeratotic fingertips (mechanic’s hands), and arthritis. It is associated with antibodies against aminoacyl tRNA synthetase enzyme, the most common autoantibody being the anti-Jo-1. An 18-year-old girl presented with weakness of both the upper and lower limb, swelling and generalized body pain, difficulty in swallowing. MRI of the thigh was highly suggestive of myositis with symmetrical bilateral involvement. Based on proximal muscle weakness, elevated creatine phosphokinase (CPK), and lactate dehydrogenase (LDH), strongly positive anti-nuclear antibodies human epithelial cell type-2 (ANA-HEp2), and a normal nerve conduction velocity test with precise MRI findings, a diagnosis of polymyositis was made. She was given bolus intravenous methylprednisolone for five days, followed by oral methylprednisolone with subcutaneous methotrexate weekly. She reported a 50% improvement in muscle weakness; however, partial bulbar weakness persisted at the time of discharge. On her next follow-up, her blood investigations for auto-antibodies were done. The autoantibodies anti-Jo-1 (3+), Ro-52 (2+), and Mi-2β (2+) were found to be positive. These investigations, coupled with the clinical features she was presenting, finally led us to conclude that it was a case of polymyositis complicated by the antisynthetase syndrome. Cureus 2021-01-16 /pmc/articles/PMC7883527/ /pubmed/33614339 http://dx.doi.org/10.7759/cureus.12737 Text en Copyright © 2021, Khan et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine Khan, Aadil M Ahmad, Faim Rehman, Usama Jindal, Himanshu Harimohan, Hridya A Clinical Case of Polymyositis Complicated by Antisynthetase Syndrome |
title | A Clinical Case of Polymyositis Complicated by Antisynthetase Syndrome |
title_full | A Clinical Case of Polymyositis Complicated by Antisynthetase Syndrome |
title_fullStr | A Clinical Case of Polymyositis Complicated by Antisynthetase Syndrome |
title_full_unstemmed | A Clinical Case of Polymyositis Complicated by Antisynthetase Syndrome |
title_short | A Clinical Case of Polymyositis Complicated by Antisynthetase Syndrome |
title_sort | clinical case of polymyositis complicated by antisynthetase syndrome |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883527/ https://www.ncbi.nlm.nih.gov/pubmed/33614339 http://dx.doi.org/10.7759/cureus.12737 |
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