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Effect of PPIs on symptomatic hypocalcemia after thyroidectomy: A retrospective cohort study

OBJECTIVE: To determine differences in incidence and duration of postoperative symptomatic hypocalcemia between those taking and those not taking proton pump inhibitors (PPIs) at the time of total or completion thyroidectomy. METHODS: A retrospective chart review of adult patients who underwent tota...

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Autores principales: Gerges, Daniel, Grohmann, Nathan, Trieu, Vanessa, Brundage, William, Sajisevi, Mirabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883609/
https://www.ncbi.nlm.nih.gov/pubmed/33614944
http://dx.doi.org/10.1002/lio2.515
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author Gerges, Daniel
Grohmann, Nathan
Trieu, Vanessa
Brundage, William
Sajisevi, Mirabelle
author_facet Gerges, Daniel
Grohmann, Nathan
Trieu, Vanessa
Brundage, William
Sajisevi, Mirabelle
author_sort Gerges, Daniel
collection PubMed
description OBJECTIVE: To determine differences in incidence and duration of postoperative symptomatic hypocalcemia between those taking and those not taking proton pump inhibitors (PPIs) at the time of total or completion thyroidectomy. METHODS: A retrospective chart review of adult patients who underwent total or completion thyroidectomy at a tertiary medical center between January 2013 and January 2018 was performed. Development of symptomatic hypocalcemia, duration of symptoms, postoperative parathyroid hormone levels, PPI usage and emergency department (ED) visits were recorded. RESULTS: Data from 371 patients were analyzed. Sixty of 371 (16.2%) patients developed symptomatic hypocalcemia. Sixteen of 89 (18.0%) patients on a PPI developed symptomatic hypocalcemia compared to 44 of 282 (15.6%) not on a PPI (P = .63). The overall average duration of symptoms was 4.3 days (SD [SD] 3.77 days). The average duration of symptoms in those on a PPI was 4.8 days (SD 2.8 days) compared to 4.2 days (SD 4.1 days) in those not on a PPI (P = 0.16). Six of 282 patients (2.1%) not taking a PPI had a postoperative ED visit, compared to two of the 89 patients (2.3%) taking a PPI (P = 1.00). CONCLUSIONS: There was no clinically significant difference in incidence and duration of symptomatic hypocalcemia or ED visits after total or completion thyroidectomy between patients that were and were not taking PPIs perioperatively. While the decision to continue PPI should be made on an individual basis, these data suggest that patients may be counseled to continue their PPI perioperatively without increased risk of symptomatic hypocalcemia. LEVEL OF EVIDENCE: 3.
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spelling pubmed-78836092021-02-19 Effect of PPIs on symptomatic hypocalcemia after thyroidectomy: A retrospective cohort study Gerges, Daniel Grohmann, Nathan Trieu, Vanessa Brundage, William Sajisevi, Mirabelle Laryngoscope Investig Otolaryngol Thyroid, Parathyroid, and Endocrine OBJECTIVE: To determine differences in incidence and duration of postoperative symptomatic hypocalcemia between those taking and those not taking proton pump inhibitors (PPIs) at the time of total or completion thyroidectomy. METHODS: A retrospective chart review of adult patients who underwent total or completion thyroidectomy at a tertiary medical center between January 2013 and January 2018 was performed. Development of symptomatic hypocalcemia, duration of symptoms, postoperative parathyroid hormone levels, PPI usage and emergency department (ED) visits were recorded. RESULTS: Data from 371 patients were analyzed. Sixty of 371 (16.2%) patients developed symptomatic hypocalcemia. Sixteen of 89 (18.0%) patients on a PPI developed symptomatic hypocalcemia compared to 44 of 282 (15.6%) not on a PPI (P = .63). The overall average duration of symptoms was 4.3 days (SD [SD] 3.77 days). The average duration of symptoms in those on a PPI was 4.8 days (SD 2.8 days) compared to 4.2 days (SD 4.1 days) in those not on a PPI (P = 0.16). Six of 282 patients (2.1%) not taking a PPI had a postoperative ED visit, compared to two of the 89 patients (2.3%) taking a PPI (P = 1.00). CONCLUSIONS: There was no clinically significant difference in incidence and duration of symptomatic hypocalcemia or ED visits after total or completion thyroidectomy between patients that were and were not taking PPIs perioperatively. While the decision to continue PPI should be made on an individual basis, these data suggest that patients may be counseled to continue their PPI perioperatively without increased risk of symptomatic hypocalcemia. LEVEL OF EVIDENCE: 3. John Wiley & Sons, Inc. 2020-12-24 /pmc/articles/PMC7883609/ /pubmed/33614944 http://dx.doi.org/10.1002/lio2.515 Text en © 2020 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals LLC. on behalf of The Triological Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Thyroid, Parathyroid, and Endocrine
Gerges, Daniel
Grohmann, Nathan
Trieu, Vanessa
Brundage, William
Sajisevi, Mirabelle
Effect of PPIs on symptomatic hypocalcemia after thyroidectomy: A retrospective cohort study
title Effect of PPIs on symptomatic hypocalcemia after thyroidectomy: A retrospective cohort study
title_full Effect of PPIs on symptomatic hypocalcemia after thyroidectomy: A retrospective cohort study
title_fullStr Effect of PPIs on symptomatic hypocalcemia after thyroidectomy: A retrospective cohort study
title_full_unstemmed Effect of PPIs on symptomatic hypocalcemia after thyroidectomy: A retrospective cohort study
title_short Effect of PPIs on symptomatic hypocalcemia after thyroidectomy: A retrospective cohort study
title_sort effect of ppis on symptomatic hypocalcemia after thyroidectomy: a retrospective cohort study
topic Thyroid, Parathyroid, and Endocrine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883609/
https://www.ncbi.nlm.nih.gov/pubmed/33614944
http://dx.doi.org/10.1002/lio2.515
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