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Seroprevalence of antibodies to SARS-CoV-2 in healthcare workers: a cross-sectional study

OBJECTIVE: We sought to determine the extent of SARS-CoV-2 seroprevalence and the factors associated with seroprevalence across a diverse cohort of healthcare workers. DESIGN: Observational cohort study of healthcare workers, including SARS-CoV-2 serology testing and participant questionnaires. SETT...

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Autores principales: Ebinger, Joseph E, Botwin, Gregory J, Albert, Christine M, Alotaibi, Mona, Arditi, Moshe, Berg, Anders H, Binek, Aleksandra, Botting, Patrick, Fert-Bober, Justyna, Figueiredo, Jane C, Grein, Jonathan D, Hasan, Wohaib, Henglin, Mir, Hussain, Shehnaz K, Jain, Mohit, Joung, Sandy, Karin, Michael, Kim, Elizabeth H, Li, Dalin, Liu, Yunxian, Luong, Eric, McGovern, Dermot P B, Merchant, Akil, Merin, Noah, Miles, Peggy B, Minissian, Margo, Nguyen, Trevor Trung, Raedschelders, Koen, Rashid, Mohamad A, Riera, Celine E, Riggs, Richard V, Sharma, Sonia, Sternbach, Sarah, Sun, Nancy, Tourtellotte, Warren G, Van Eyk, Jennifer E, Sobhani, Kimia, Braun, Jonathan G, Cheng, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883610/
https://www.ncbi.nlm.nih.gov/pubmed/33579769
http://dx.doi.org/10.1136/bmjopen-2020-043584
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author Ebinger, Joseph E
Botwin, Gregory J
Albert, Christine M
Alotaibi, Mona
Arditi, Moshe
Berg, Anders H
Binek, Aleksandra
Botting, Patrick
Fert-Bober, Justyna
Figueiredo, Jane C
Grein, Jonathan D
Hasan, Wohaib
Henglin, Mir
Hussain, Shehnaz K
Jain, Mohit
Joung, Sandy
Karin, Michael
Kim, Elizabeth H
Li, Dalin
Liu, Yunxian
Luong, Eric
McGovern, Dermot P B
Merchant, Akil
Merin, Noah
Miles, Peggy B
Minissian, Margo
Nguyen, Trevor Trung
Raedschelders, Koen
Rashid, Mohamad A
Riera, Celine E
Riggs, Richard V
Sharma, Sonia
Sternbach, Sarah
Sun, Nancy
Tourtellotte, Warren G
Van Eyk, Jennifer E
Sobhani, Kimia
Braun, Jonathan G
Cheng, Susan
author_facet Ebinger, Joseph E
Botwin, Gregory J
Albert, Christine M
Alotaibi, Mona
Arditi, Moshe
Berg, Anders H
Binek, Aleksandra
Botting, Patrick
Fert-Bober, Justyna
Figueiredo, Jane C
Grein, Jonathan D
Hasan, Wohaib
Henglin, Mir
Hussain, Shehnaz K
Jain, Mohit
Joung, Sandy
Karin, Michael
Kim, Elizabeth H
Li, Dalin
Liu, Yunxian
Luong, Eric
McGovern, Dermot P B
Merchant, Akil
Merin, Noah
Miles, Peggy B
Minissian, Margo
Nguyen, Trevor Trung
Raedschelders, Koen
Rashid, Mohamad A
Riera, Celine E
Riggs, Richard V
Sharma, Sonia
Sternbach, Sarah
Sun, Nancy
Tourtellotte, Warren G
Van Eyk, Jennifer E
Sobhani, Kimia
Braun, Jonathan G
Cheng, Susan
author_sort Ebinger, Joseph E
collection PubMed
description OBJECTIVE: We sought to determine the extent of SARS-CoV-2 seroprevalence and the factors associated with seroprevalence across a diverse cohort of healthcare workers. DESIGN: Observational cohort study of healthcare workers, including SARS-CoV-2 serology testing and participant questionnaires. SETTINGS: A multisite healthcare delivery system located in Los Angeles County. PARTICIPANTS: A diverse and unselected population of adults (n=6062) employed in a multisite healthcare delivery system located in Los Angeles County, including individuals with direct patient contact and others with non-patient-oriented work functions. MAIN OUTCOMES: Using Bayesian and multivariate analyses, we estimated seroprevalence and factors associated with seropositivity and antibody levels, including pre-existing demographic and clinical characteristics; potential COVID-19 illness-related exposures; and symptoms consistent with COVID-19 infection. RESULTS: We observed a seroprevalence rate of 4.1%, with anosmia as the most prominently associated self-reported symptom (OR 11.04, p<0.001) in addition to fever (OR 2.02, p=0.002) and myalgias (OR 1.65, p=0.035). After adjusting for potential confounders, seroprevalence was also associated with Hispanic ethnicity (OR 1.98, p=0.001) and African-American race (OR 2.02, p=0.027) as well as contact with a COVID-19-diagnosed individual in the household (OR 5.73, p<0.001) or clinical work setting (OR 1.76, p=0.002). Importantly, African-American race and Hispanic ethnicity were associated with antibody positivity even after adjusting for personal COVID-19 diagnosis status, suggesting the contribution of unmeasured structural or societal factors. CONCLUSION AND RELEVANCE: The demographic factors associated with SARS-CoV-2 seroprevalence among our healthcare workers underscore the importance of exposure sources beyond the workplace. The size and diversity of our study population, combined with robust survey and modelling techniques, provide a vibrant picture of the demographic factors, exposures and symptoms that can identify individuals with susceptibility as well as potential to mount an immune response to COVID-19.
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spelling pubmed-78836102021-02-16 Seroprevalence of antibodies to SARS-CoV-2 in healthcare workers: a cross-sectional study Ebinger, Joseph E Botwin, Gregory J Albert, Christine M Alotaibi, Mona Arditi, Moshe Berg, Anders H Binek, Aleksandra Botting, Patrick Fert-Bober, Justyna Figueiredo, Jane C Grein, Jonathan D Hasan, Wohaib Henglin, Mir Hussain, Shehnaz K Jain, Mohit Joung, Sandy Karin, Michael Kim, Elizabeth H Li, Dalin Liu, Yunxian Luong, Eric McGovern, Dermot P B Merchant, Akil Merin, Noah Miles, Peggy B Minissian, Margo Nguyen, Trevor Trung Raedschelders, Koen Rashid, Mohamad A Riera, Celine E Riggs, Richard V Sharma, Sonia Sternbach, Sarah Sun, Nancy Tourtellotte, Warren G Van Eyk, Jennifer E Sobhani, Kimia Braun, Jonathan G Cheng, Susan BMJ Open Public Health OBJECTIVE: We sought to determine the extent of SARS-CoV-2 seroprevalence and the factors associated with seroprevalence across a diverse cohort of healthcare workers. DESIGN: Observational cohort study of healthcare workers, including SARS-CoV-2 serology testing and participant questionnaires. SETTINGS: A multisite healthcare delivery system located in Los Angeles County. PARTICIPANTS: A diverse and unselected population of adults (n=6062) employed in a multisite healthcare delivery system located in Los Angeles County, including individuals with direct patient contact and others with non-patient-oriented work functions. MAIN OUTCOMES: Using Bayesian and multivariate analyses, we estimated seroprevalence and factors associated with seropositivity and antibody levels, including pre-existing demographic and clinical characteristics; potential COVID-19 illness-related exposures; and symptoms consistent with COVID-19 infection. RESULTS: We observed a seroprevalence rate of 4.1%, with anosmia as the most prominently associated self-reported symptom (OR 11.04, p<0.001) in addition to fever (OR 2.02, p=0.002) and myalgias (OR 1.65, p=0.035). After adjusting for potential confounders, seroprevalence was also associated with Hispanic ethnicity (OR 1.98, p=0.001) and African-American race (OR 2.02, p=0.027) as well as contact with a COVID-19-diagnosed individual in the household (OR 5.73, p<0.001) or clinical work setting (OR 1.76, p=0.002). Importantly, African-American race and Hispanic ethnicity were associated with antibody positivity even after adjusting for personal COVID-19 diagnosis status, suggesting the contribution of unmeasured structural or societal factors. CONCLUSION AND RELEVANCE: The demographic factors associated with SARS-CoV-2 seroprevalence among our healthcare workers underscore the importance of exposure sources beyond the workplace. The size and diversity of our study population, combined with robust survey and modelling techniques, provide a vibrant picture of the demographic factors, exposures and symptoms that can identify individuals with susceptibility as well as potential to mount an immune response to COVID-19. BMJ Publishing Group 2021-02-12 /pmc/articles/PMC7883610/ /pubmed/33579769 http://dx.doi.org/10.1136/bmjopen-2020-043584 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle Public Health
Ebinger, Joseph E
Botwin, Gregory J
Albert, Christine M
Alotaibi, Mona
Arditi, Moshe
Berg, Anders H
Binek, Aleksandra
Botting, Patrick
Fert-Bober, Justyna
Figueiredo, Jane C
Grein, Jonathan D
Hasan, Wohaib
Henglin, Mir
Hussain, Shehnaz K
Jain, Mohit
Joung, Sandy
Karin, Michael
Kim, Elizabeth H
Li, Dalin
Liu, Yunxian
Luong, Eric
McGovern, Dermot P B
Merchant, Akil
Merin, Noah
Miles, Peggy B
Minissian, Margo
Nguyen, Trevor Trung
Raedschelders, Koen
Rashid, Mohamad A
Riera, Celine E
Riggs, Richard V
Sharma, Sonia
Sternbach, Sarah
Sun, Nancy
Tourtellotte, Warren G
Van Eyk, Jennifer E
Sobhani, Kimia
Braun, Jonathan G
Cheng, Susan
Seroprevalence of antibodies to SARS-CoV-2 in healthcare workers: a cross-sectional study
title Seroprevalence of antibodies to SARS-CoV-2 in healthcare workers: a cross-sectional study
title_full Seroprevalence of antibodies to SARS-CoV-2 in healthcare workers: a cross-sectional study
title_fullStr Seroprevalence of antibodies to SARS-CoV-2 in healthcare workers: a cross-sectional study
title_full_unstemmed Seroprevalence of antibodies to SARS-CoV-2 in healthcare workers: a cross-sectional study
title_short Seroprevalence of antibodies to SARS-CoV-2 in healthcare workers: a cross-sectional study
title_sort seroprevalence of antibodies to sars-cov-2 in healthcare workers: a cross-sectional study
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883610/
https://www.ncbi.nlm.nih.gov/pubmed/33579769
http://dx.doi.org/10.1136/bmjopen-2020-043584
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