Tanshinone IIA: A Review of its Anticancer Effects

Tanshinone IIA (Tan IIA) is a pharmacologically lipophilic active constituent isolated from the roots and rhizomes of the Chinese medicinal herb Salvia miltiorrhiza Bunge (Danshen). Tan IIA is currently used in China and other neighboring countries to treat patients with cardiovascular system, diabe...

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Autores principales: Fang, Zhong‐ying, Zhang, Miao, Liu, Jia-ning, Zhao, Xue, Zhang, Yong-qing, Fang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883641/
https://www.ncbi.nlm.nih.gov/pubmed/33597880
http://dx.doi.org/10.3389/fphar.2020.611087
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author Fang, Zhong‐ying
Zhang, Miao
Liu, Jia-ning
Zhao, Xue
Zhang, Yong-qing
Fang, Lei
author_facet Fang, Zhong‐ying
Zhang, Miao
Liu, Jia-ning
Zhao, Xue
Zhang, Yong-qing
Fang, Lei
author_sort Fang, Zhong‐ying
collection PubMed
description Tanshinone IIA (Tan IIA) is a pharmacologically lipophilic active constituent isolated from the roots and rhizomes of the Chinese medicinal herb Salvia miltiorrhiza Bunge (Danshen). Tan IIA is currently used in China and other neighboring countries to treat patients with cardiovascular system, diabetes, apoplexy, arthritis, sepsis, and other diseases. Recently, it was reported that tan IIA could have a wide range of antitumor effects on several human tumor cell lines, but the research of the mechanism of tan IIA is relatively scattered in cancer. This review aimed to summarize the recent advances in the anticancer effects of tan IIA and to provide a novel perspective on clinical use of tan IIA.
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spelling pubmed-78836412021-02-16 Tanshinone IIA: A Review of its Anticancer Effects Fang, Zhong‐ying Zhang, Miao Liu, Jia-ning Zhao, Xue Zhang, Yong-qing Fang, Lei Front Pharmacol Pharmacology Tanshinone IIA (Tan IIA) is a pharmacologically lipophilic active constituent isolated from the roots and rhizomes of the Chinese medicinal herb Salvia miltiorrhiza Bunge (Danshen). Tan IIA is currently used in China and other neighboring countries to treat patients with cardiovascular system, diabetes, apoplexy, arthritis, sepsis, and other diseases. Recently, it was reported that tan IIA could have a wide range of antitumor effects on several human tumor cell lines, but the research of the mechanism of tan IIA is relatively scattered in cancer. This review aimed to summarize the recent advances in the anticancer effects of tan IIA and to provide a novel perspective on clinical use of tan IIA. Frontiers Media S.A. 2021-01-14 /pmc/articles/PMC7883641/ /pubmed/33597880 http://dx.doi.org/10.3389/fphar.2020.611087 Text en Copyright © 2021 Fang, Zhang, Liu, Zhao, Zhang and Fang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Fang, Zhong‐ying
Zhang, Miao
Liu, Jia-ning
Zhao, Xue
Zhang, Yong-qing
Fang, Lei
Tanshinone IIA: A Review of its Anticancer Effects
title Tanshinone IIA: A Review of its Anticancer Effects
title_full Tanshinone IIA: A Review of its Anticancer Effects
title_fullStr Tanshinone IIA: A Review of its Anticancer Effects
title_full_unstemmed Tanshinone IIA: A Review of its Anticancer Effects
title_short Tanshinone IIA: A Review of its Anticancer Effects
title_sort tanshinone iia: a review of its anticancer effects
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883641/
https://www.ncbi.nlm.nih.gov/pubmed/33597880
http://dx.doi.org/10.3389/fphar.2020.611087
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