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Simvastatin and ROCK Inhibitor Y-27632 Inhibit Myofibroblast Differentiation of Graves’ Ophthalmopathy-Derived Orbital Fibroblasts via RhoA-Mediated ERK and p38 Signaling Pathways

Transforming growth factor-β (TGF-β)-induced differentiation of orbital fibroblasts into myofibroblasts is an important pathogenesis of Graves’ ophthalmopathy (GO) and leads to orbital tissue fibrosis. In the present study, we explored the antifibrotic effects of simvastatin and ROCK inhibitor Y-276...

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Detalles Bibliográficos
Autores principales:	Wei, Yi-Hsuan, Liao, Shu-Lang, Wang, Sen-Hsu, Wang, Chia-Chun, Yang, Chang-Hao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883643/ https://www.ncbi.nlm.nih.gov/pubmed/33597925 http://dx.doi.org/10.3389/fendo.2020.607968

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