High expression of SARS-CoV-2 entry factors in human conjunctival goblet cells

The angiotensin-converting enzyme 2 (ACE2) receptor has been proved for SARS-CoV-2 cell entry after auxiliary cellular protease priming by transmembrane protease serine 2 (TMPRSS2), but the co-effect of this molecular mechanism was unknown. Here, single-cell sequencing was performed with human conju...

Descripción completa

Detalles Bibliográficos
Autores principales: Ma, Ruiqi, Gan, Lu, Jiang, Sanjie, Ding, Peiwen, Chen, Dongsheng, Wu, Jihong, Qian, Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883706/
https://www.ncbi.nlm.nih.gov/pubmed/33600811
http://dx.doi.org/10.1016/j.exer.2021.108501
Descripción
Sumario:The angiotensin-converting enzyme 2 (ACE2) receptor has been proved for SARS-CoV-2 cell entry after auxiliary cellular protease priming by transmembrane protease serine 2 (TMPRSS2), but the co-effect of this molecular mechanism was unknown. Here, single-cell sequencing was performed with human conjunctiva and the results have shown that ACE2 and TMPRSS2 were highly co-expressed in the goblet cells with genes involved in immunity process. This identification of conjunctival cell types which are permissive to virus entry would help to understand the process by which SARS-CoV-2 infection was established. These finding might be suggestive for COVID-19 control and protection.

Ejemplares similares