The role of Sfrp and DKK proteins in cardiomyocyte development

In this review, we summarize the role of Wnt proteins in cardiomyogenesis. More specifically, we focus on how the development of cardiomyocytes from precursor cells involves a complex interplay between Wnt canonical β‐catenin signaling pathways and Wnt noncanonical signaling pathways involving PCP a...

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Detalles Bibliográficos
Autores principales: Hsueh, Ying‐Chang, Hodgkinson, Conrad P., Gomez, Jose A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883806/
https://www.ncbi.nlm.nih.gov/pubmed/33587322
http://dx.doi.org/10.14814/phy2.14678
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author Hsueh, Ying‐Chang
Hodgkinson, Conrad P.
Gomez, Jose A.
author_facet Hsueh, Ying‐Chang
Hodgkinson, Conrad P.
Gomez, Jose A.
author_sort Hsueh, Ying‐Chang
collection PubMed
description In this review, we summarize the role of Wnt proteins in cardiomyogenesis. More specifically, we focus on how the development of cardiomyocytes from precursor cells involves a complex interplay between Wnt canonical β‐catenin signaling pathways and Wnt noncanonical signaling pathways involving PCP and JNK. We also describe recent literature which suggests that endogenous Wnt inhibitors such as the Sfrp and DKK proteins play important roles in regulating the cardiomyocyte differentiation.
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spelling pubmed-78838062021-02-19 The role of Sfrp and DKK proteins in cardiomyocyte development Hsueh, Ying‐Chang Hodgkinson, Conrad P. Gomez, Jose A. Physiol Rep Reviews In this review, we summarize the role of Wnt proteins in cardiomyogenesis. More specifically, we focus on how the development of cardiomyocytes from precursor cells involves a complex interplay between Wnt canonical β‐catenin signaling pathways and Wnt noncanonical signaling pathways involving PCP and JNK. We also describe recent literature which suggests that endogenous Wnt inhibitors such as the Sfrp and DKK proteins play important roles in regulating the cardiomyocyte differentiation. John Wiley and Sons Inc. 2021-02-15 /pmc/articles/PMC7883806/ /pubmed/33587322 http://dx.doi.org/10.14814/phy2.14678 Text en © 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Hsueh, Ying‐Chang
Hodgkinson, Conrad P.
Gomez, Jose A.
The role of Sfrp and DKK proteins in cardiomyocyte development
title The role of Sfrp and DKK proteins in cardiomyocyte development
title_full The role of Sfrp and DKK proteins in cardiomyocyte development
title_fullStr The role of Sfrp and DKK proteins in cardiomyocyte development
title_full_unstemmed The role of Sfrp and DKK proteins in cardiomyocyte development
title_short The role of Sfrp and DKK proteins in cardiomyocyte development
title_sort role of sfrp and dkk proteins in cardiomyocyte development
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883806/
https://www.ncbi.nlm.nih.gov/pubmed/33587322
http://dx.doi.org/10.14814/phy2.14678
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