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Fatal New-Onset Congestive Heart Failure Related to Adalimumab Use in a Patient with Relapsing Hidradenitis Suppurativa: A Case Report

Patient: Male, 67-year-old Final Diagnosis: Congestive heart failure Symptoms: Dyspnea • lower extremity edema • orthopnea • SOB Medication: — Clinical Procedure: — Specialty: Family Medicine OBJECTIVE: Challenging differential diagnosis BACKGROUND: Tumor necrosis factor (TNF)-alpha inhibitors are e...

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Autores principales: López, Claudia Mansitó, Laboy, Paola Torres, Bou, Miguel Ortiz, Noriega, Aida Quintero, Rivera, Vielka Cintrón
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883937/
https://www.ncbi.nlm.nih.gov/pubmed/33563886
http://dx.doi.org/10.12659/AJCR.929148
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author López, Claudia Mansitó
Laboy, Paola Torres
Bou, Miguel Ortiz
Noriega, Aida Quintero
Rivera, Vielka Cintrón
author_facet López, Claudia Mansitó
Laboy, Paola Torres
Bou, Miguel Ortiz
Noriega, Aida Quintero
Rivera, Vielka Cintrón
author_sort López, Claudia Mansitó
collection PubMed
description Patient: Male, 67-year-old Final Diagnosis: Congestive heart failure Symptoms: Dyspnea • lower extremity edema • orthopnea • SOB Medication: — Clinical Procedure: — Specialty: Family Medicine OBJECTIVE: Challenging differential diagnosis BACKGROUND: Tumor necrosis factor (TNF)-alpha inhibitors are essential treatments in several inflammatory conditions such as hidradenitis suppurativa (HS). However, they are not without associated risks. In rare cases, new-onset and exacerbations of heart failure have been associated with their use. The purpose of this report is to raise awareness of the need for further study of adalimumab for this adverse effect, as well as to recognize the need for research to find new HS treatment modalities for better care of the broad patient population. CASE REPORT: We report the case of a 67-year-old man with a history of severe HS and major depressive disorder who came to our hospital complaining of dyspnea, fatigue upon exertion, and lower-extremity edema of 2 weeks’ evolution. Symptoms began after the re-initiation of adalimumab for his severe HS. During hospitalization, he was diagnosed with decompensated congestive heart failure (CHF). Extensive studies, looking for ischemic or infectious etiology, yielded negative results. Being aware of adalimumab’s potential adverse effects, the team discontinued the medication as a probable cause of his condition. Unfortunately, the patient died secondary to heart failure and septicemia. CONCLUSIONS: The unusual but potentially life-threatening appearance of heart failure secondary to adalimumab use merits thorough attention by primary care doctors and specialists. This adverse event’s rare occurrence can underestimate the number of fatalities associated with adalimumab and congestive heart failure.
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spelling pubmed-78839372021-03-10 Fatal New-Onset Congestive Heart Failure Related to Adalimumab Use in a Patient with Relapsing Hidradenitis Suppurativa: A Case Report López, Claudia Mansitó Laboy, Paola Torres Bou, Miguel Ortiz Noriega, Aida Quintero Rivera, Vielka Cintrón Am J Case Rep Articles Patient: Male, 67-year-old Final Diagnosis: Congestive heart failure Symptoms: Dyspnea • lower extremity edema • orthopnea • SOB Medication: — Clinical Procedure: — Specialty: Family Medicine OBJECTIVE: Challenging differential diagnosis BACKGROUND: Tumor necrosis factor (TNF)-alpha inhibitors are essential treatments in several inflammatory conditions such as hidradenitis suppurativa (HS). However, they are not without associated risks. In rare cases, new-onset and exacerbations of heart failure have been associated with their use. The purpose of this report is to raise awareness of the need for further study of adalimumab for this adverse effect, as well as to recognize the need for research to find new HS treatment modalities for better care of the broad patient population. CASE REPORT: We report the case of a 67-year-old man with a history of severe HS and major depressive disorder who came to our hospital complaining of dyspnea, fatigue upon exertion, and lower-extremity edema of 2 weeks’ evolution. Symptoms began after the re-initiation of adalimumab for his severe HS. During hospitalization, he was diagnosed with decompensated congestive heart failure (CHF). Extensive studies, looking for ischemic or infectious etiology, yielded negative results. Being aware of adalimumab’s potential adverse effects, the team discontinued the medication as a probable cause of his condition. Unfortunately, the patient died secondary to heart failure and septicemia. CONCLUSIONS: The unusual but potentially life-threatening appearance of heart failure secondary to adalimumab use merits thorough attention by primary care doctors and specialists. This adverse event’s rare occurrence can underestimate the number of fatalities associated with adalimumab and congestive heart failure. International Scientific Literature, Inc. 2021-02-10 /pmc/articles/PMC7883937/ /pubmed/33563886 http://dx.doi.org/10.12659/AJCR.929148 Text en © Am J Case Rep, 2021 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Articles
López, Claudia Mansitó
Laboy, Paola Torres
Bou, Miguel Ortiz
Noriega, Aida Quintero
Rivera, Vielka Cintrón
Fatal New-Onset Congestive Heart Failure Related to Adalimumab Use in a Patient with Relapsing Hidradenitis Suppurativa: A Case Report
title Fatal New-Onset Congestive Heart Failure Related to Adalimumab Use in a Patient with Relapsing Hidradenitis Suppurativa: A Case Report
title_full Fatal New-Onset Congestive Heart Failure Related to Adalimumab Use in a Patient with Relapsing Hidradenitis Suppurativa: A Case Report
title_fullStr Fatal New-Onset Congestive Heart Failure Related to Adalimumab Use in a Patient with Relapsing Hidradenitis Suppurativa: A Case Report
title_full_unstemmed Fatal New-Onset Congestive Heart Failure Related to Adalimumab Use in a Patient with Relapsing Hidradenitis Suppurativa: A Case Report
title_short Fatal New-Onset Congestive Heart Failure Related to Adalimumab Use in a Patient with Relapsing Hidradenitis Suppurativa: A Case Report
title_sort fatal new-onset congestive heart failure related to adalimumab use in a patient with relapsing hidradenitis suppurativa: a case report
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883937/
https://www.ncbi.nlm.nih.gov/pubmed/33563886
http://dx.doi.org/10.12659/AJCR.929148
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