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Fatal New-Onset Congestive Heart Failure Related to Adalimumab Use in a Patient with Relapsing Hidradenitis Suppurativa: A Case Report
Patient: Male, 67-year-old Final Diagnosis: Congestive heart failure Symptoms: Dyspnea • lower extremity edema • orthopnea • SOB Medication: — Clinical Procedure: — Specialty: Family Medicine OBJECTIVE: Challenging differential diagnosis BACKGROUND: Tumor necrosis factor (TNF)-alpha inhibitors are e...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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International Scientific Literature, Inc.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883937/ https://www.ncbi.nlm.nih.gov/pubmed/33563886 http://dx.doi.org/10.12659/AJCR.929148 |
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author | López, Claudia Mansitó Laboy, Paola Torres Bou, Miguel Ortiz Noriega, Aida Quintero Rivera, Vielka Cintrón |
author_facet | López, Claudia Mansitó Laboy, Paola Torres Bou, Miguel Ortiz Noriega, Aida Quintero Rivera, Vielka Cintrón |
author_sort | López, Claudia Mansitó |
collection | PubMed |
description | Patient: Male, 67-year-old Final Diagnosis: Congestive heart failure Symptoms: Dyspnea • lower extremity edema • orthopnea • SOB Medication: — Clinical Procedure: — Specialty: Family Medicine OBJECTIVE: Challenging differential diagnosis BACKGROUND: Tumor necrosis factor (TNF)-alpha inhibitors are essential treatments in several inflammatory conditions such as hidradenitis suppurativa (HS). However, they are not without associated risks. In rare cases, new-onset and exacerbations of heart failure have been associated with their use. The purpose of this report is to raise awareness of the need for further study of adalimumab for this adverse effect, as well as to recognize the need for research to find new HS treatment modalities for better care of the broad patient population. CASE REPORT: We report the case of a 67-year-old man with a history of severe HS and major depressive disorder who came to our hospital complaining of dyspnea, fatigue upon exertion, and lower-extremity edema of 2 weeks’ evolution. Symptoms began after the re-initiation of adalimumab for his severe HS. During hospitalization, he was diagnosed with decompensated congestive heart failure (CHF). Extensive studies, looking for ischemic or infectious etiology, yielded negative results. Being aware of adalimumab’s potential adverse effects, the team discontinued the medication as a probable cause of his condition. Unfortunately, the patient died secondary to heart failure and septicemia. CONCLUSIONS: The unusual but potentially life-threatening appearance of heart failure secondary to adalimumab use merits thorough attention by primary care doctors and specialists. This adverse event’s rare occurrence can underestimate the number of fatalities associated with adalimumab and congestive heart failure. |
format | Online Article Text |
id | pubmed-7883937 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78839372021-03-10 Fatal New-Onset Congestive Heart Failure Related to Adalimumab Use in a Patient with Relapsing Hidradenitis Suppurativa: A Case Report López, Claudia Mansitó Laboy, Paola Torres Bou, Miguel Ortiz Noriega, Aida Quintero Rivera, Vielka Cintrón Am J Case Rep Articles Patient: Male, 67-year-old Final Diagnosis: Congestive heart failure Symptoms: Dyspnea • lower extremity edema • orthopnea • SOB Medication: — Clinical Procedure: — Specialty: Family Medicine OBJECTIVE: Challenging differential diagnosis BACKGROUND: Tumor necrosis factor (TNF)-alpha inhibitors are essential treatments in several inflammatory conditions such as hidradenitis suppurativa (HS). However, they are not without associated risks. In rare cases, new-onset and exacerbations of heart failure have been associated with their use. The purpose of this report is to raise awareness of the need for further study of adalimumab for this adverse effect, as well as to recognize the need for research to find new HS treatment modalities for better care of the broad patient population. CASE REPORT: We report the case of a 67-year-old man with a history of severe HS and major depressive disorder who came to our hospital complaining of dyspnea, fatigue upon exertion, and lower-extremity edema of 2 weeks’ evolution. Symptoms began after the re-initiation of adalimumab for his severe HS. During hospitalization, he was diagnosed with decompensated congestive heart failure (CHF). Extensive studies, looking for ischemic or infectious etiology, yielded negative results. Being aware of adalimumab’s potential adverse effects, the team discontinued the medication as a probable cause of his condition. Unfortunately, the patient died secondary to heart failure and septicemia. CONCLUSIONS: The unusual but potentially life-threatening appearance of heart failure secondary to adalimumab use merits thorough attention by primary care doctors and specialists. This adverse event’s rare occurrence can underestimate the number of fatalities associated with adalimumab and congestive heart failure. International Scientific Literature, Inc. 2021-02-10 /pmc/articles/PMC7883937/ /pubmed/33563886 http://dx.doi.org/10.12659/AJCR.929148 Text en © Am J Case Rep, 2021 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Articles López, Claudia Mansitó Laboy, Paola Torres Bou, Miguel Ortiz Noriega, Aida Quintero Rivera, Vielka Cintrón Fatal New-Onset Congestive Heart Failure Related to Adalimumab Use in a Patient with Relapsing Hidradenitis Suppurativa: A Case Report |
title | Fatal New-Onset Congestive Heart Failure Related to Adalimumab Use in a Patient with Relapsing Hidradenitis Suppurativa: A Case Report |
title_full | Fatal New-Onset Congestive Heart Failure Related to Adalimumab Use in a Patient with Relapsing Hidradenitis Suppurativa: A Case Report |
title_fullStr | Fatal New-Onset Congestive Heart Failure Related to Adalimumab Use in a Patient with Relapsing Hidradenitis Suppurativa: A Case Report |
title_full_unstemmed | Fatal New-Onset Congestive Heart Failure Related to Adalimumab Use in a Patient with Relapsing Hidradenitis Suppurativa: A Case Report |
title_short | Fatal New-Onset Congestive Heart Failure Related to Adalimumab Use in a Patient with Relapsing Hidradenitis Suppurativa: A Case Report |
title_sort | fatal new-onset congestive heart failure related to adalimumab use in a patient with relapsing hidradenitis suppurativa: a case report |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883937/ https://www.ncbi.nlm.nih.gov/pubmed/33563886 http://dx.doi.org/10.12659/AJCR.929148 |
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