New Conceptual Toxicokinetic Model to Assess Synergistic Mixture Effects between the Aromatic Hydrocarbon β-Naphthoflavone and the Azole Nocodazole on the CYP1A Biomarker in a Fish Cell Line

[Image: see text] Toxicokinetic interactions with catabolic cytochrome P450 (CYP) enzymes can inhibit chemical elimination pathways and cause synergistic mixture effects. We have created a mathematical bottom-up model for a synergistic mixture effect where we fit a multidimensional function to a giv...

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Detalles Bibliográficos
Autores principales: Fallahi, Shirin, Mlnaříková, Marie, Alvord, Charlotte, Alendal, Guttorm, Frøysa, Håvard G., Lundh, Torbjörn, Celander, Malin C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884012/
https://www.ncbi.nlm.nih.gov/pubmed/33054185
http://dx.doi.org/10.1021/acs.est.0c04839

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