Targeting age‐specific changes in CD4(+) T cell metabolism ameliorates alloimmune responses and prolongs graft survival

Age impacts alloimmunity. Effects of aging on T‐cell metabolism and the potential to interfere with immunosuppressants have not been explored yet. Here, we dissected metabolic pathways of CD4(+) and CD8(+) T cells in aging and offer novel immunosuppressive targets. Upon activation, CD4(+) T cells fr...

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Detalles Bibliográficos
Autores principales: Nian, Yeqi, Iske, Jasper, Maenosono, Ryoichi, Minami, Koichiro, Heinbokel, Timm, Quante, Markus, Liu, Yang, Azuma, Haruhito, Yang, Jinrui, Abdi, Reza, Zhou, Hao, Elkhal, Abdallah, Tullius, Stefan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884034/
https://www.ncbi.nlm.nih.gov/pubmed/33497523
http://dx.doi.org/10.1111/acel.13299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884034/
https://www.ncbi.nlm.nih.gov/pubmed/33497523
http://dx.doi.org/10.1111/acel.13299

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