Cargando…

Mtor inhibition by INK128 extends functions of the ovary reconstituted from germline stem cells in aging and premature aging mice

Stem cell transplantation has been generally considered as promising therapeutics in preserving or recovering functions of lost, damaged, or aging tissues. Transplantation of primordial germ cells (PGCs) or oogonia stem cells (OSCs) can reconstitute ovarian functions that yet sustain for only short...

Descripción completa

Detalles Bibliográficos
Autores principales:	Heng, Dai, Sheng, Xiaoyan, Tian, Chenglei, Li, Jie, Liu, Linlin, Gou, Mo, Liu, Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884035/ https://www.ncbi.nlm.nih.gov/pubmed/33448083 http://dx.doi.org/10.1111/acel.13304

Ejemplares similares

mTOR inhibitor INK128 promotes wound healing by regulating MDSCs
por: Li, Yi, et al.
Publicado: (2021)

Correction to: mTOR inhibitor INK128 promotes wound healing by regulating MDSCs
por: Li, Yi, et al.
Publicado: (2021)

Tet1 Deficiency Leads to Premature Reproductive Aging by Reducing Spermatogonia Stem Cells and Germ Cell Differentiation
por: Huang, Guian, et al.
Publicado: (2020)

Distinct inhibitory effects on mTOR signaling by ethanol and INK128 in diffuse large B-cell lymphoma
por: Mazan-Mamczarz, Krystyna, et al.
Publicado: (2015)

CD44 positive and sorafenib insensitive hepatocellular carcinomas respond to the ATP-competitive mTOR inhibitor INK128
por: Badawi, Mohamed, et al.
Publicado: (2018)

4sc‐202 and Ink‐128 cooperate to reverse the epithelial to mesenchymal transition in OSCC
por: Yang, Xi, et al.
Publicado: (2021)

Roles of Tet2 in meiosis, fertility and reproductive aging
por: Wang, Huasong, et al.
Publicado: (2020)

INK128 Exhibits Synergy with Azoles against Exophiala spp. and Fusarium spp.
por: Gao, Lujuan, et al.
Publicado: (2016)

F128. THE AGE OF ONSET OF SCHIZOPHRENIA SPECTRUM DISORDERS
por: Miettunen, Jouko, et al.
Publicado: (2018)

Molecular Features of Polycystic Ovary Syndrome Revealed by Transcriptome Analysis of Oocytes and Cumulus Cells
por: Li, Jie, et al.
Publicado: (2021)

The preclinical evaluation of the dual mTORC1/2 inhibitor INK-128 as a potential anti-colorectal cancer agent
por: Li, Chen, et al.
Publicado: (2015)

Reversible cell cycle inhibition and premature aging features imposed by conditional expression of p16(Ink4a)
por: Boquoi, Amelie, et al.
Publicado: (2015)

GDF11 administration does not extend lifespan in a mouse model of premature aging
por: Freitas-Rodríguez, Sandra, et al.
Publicado: (2016)

Reconstituted ovaries self-assemble without an ovarian surface epithelium
por: Sosa, Enrique, et al.
Publicado: (2023)

Baicalin improves the functions of granulosa cells and the ovary in aged mice through the mTOR signaling pathway
por: Fan, Huiying, et al.
Publicado: (2022)

A Cross-Species Analysis Reveals Dysthyroidism of the Ovaries as a Common Trait of Premature Ovarian Aging
por: Colella, Marco, et al.
Publicado: (2023)

Female germline stem cells: aging and anti-aging
por: Hong, Wenli, et al.
Publicado: (2022)

Snapshot: Implications for mTOR in Aging-related Ischemia/Reperfusion Injury
por: Liu, Dong, et al.
Publicado: (2019)

Coordinated niche-associated signals promote germline homeostasis in the Drosophila ovary
por: Liu, Zhong, et al.
Publicado: (2015)

Germline progenitors and oocyte production in the honeybee queen ovary
por: Cullen, Georgia, et al.
Publicado: (2023)

Germline mutations of the INK4a-ARF gene in patients with suspected genetic predisposition to melanoma
por: Soufir, N, et al.
Publicado: (2004)

The stromal fibrosis in aging ovary
por: Umehara, Takashi, et al.
Publicado: (2018)

Reprogramming of ovarian aging epigenome by resveratrol
por: Gou, Mo, et al.
Publicado: (2022)

Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice
por: Matsushita, Yuki, et al.
Publicado: (2016)

Transplantation of the Ovary to Avoid Dysmenorrhea and Premature Menopause
por: Scott, Z. T.
Publicado: (1914)

The existence and potential of germline stem cells in the adult mammalian ovary
por: Telfer, E. E., et al.
Publicado: (2019)

Reactivation of a somatic errantivirus and germline invasion in Drosophila ovaries
por: Yoth, Marianne, et al.
Publicado: (2023)

The Continued Absence of Functional Germline Stem Cells in Adult Ovaries
por: Yoshihara, Masahito, et al.
Publicado: (2022)

Impact of Germline Depletion of Bonus on Chromatin State in Drosophila Ovaries
por: Godneeva, Baira, et al.
Publicado: (2023)

Age-related mitochondrial alterations in brain and skeletal muscle of the YAC128 model of Huntington disease
por: Bečanović, Kristina, et al.
Publicado: (2021)

Mediation of organismal aging and somatic proteostasis by the germline
por: Khodakarami, Amirabbas, et al.
Publicado: (2015)

Genetic and Chemical Effects on Somatic and Germline Aging
por: Lee, Myon-Hee, et al.
Publicado: (2020)

Aging germline stem cells in C. elegans
por: Hubbard, E Jane
Publicado: (2020)

Nucleophagy delays aging and preserves germline immortality
por: Papandreou, Margarita-Elena, et al.
Publicado: (2022)

Characteristics of Female Germline Stem Cells from Porcine Ovaries at Sexual Maturity
por: Hou, Lin, et al.
Publicado: (2018)

Corrigendum: Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice
por: Matsushita, Yuki, et al.
Publicado: (2016)

Stem cells in aged mammalian ovaries
por: Virant-Klun, Irma, et al.
Publicado: (2010)

The Role of PEDF in Reproductive Aging of the Ovary †
por: Nemerovsky, Luba, et al.
Publicado: (2022)

Transcriptomes of the Premature and Mature Ovaries of an Ascidian, Ciona intestinalis
por: Kawada, Tsuyoshi, et al.
Publicado: (2017)

CCD Multi-Ion Image Sensor with Four 128 × 128 Pixels Array
por: Hattori, Toshiaki, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_4ochqo99ig40c4ubtcr8dh167r