Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair‐deficient mice

Dietary restriction (DR) and rapamycin extend healthspan and life span across multiple species. We have recently shown that DR in progeroid DNA repair‐deficient mice dramatically extended healthspan and trippled life span. Here, we show that rapamycin, while significantly lowering mTOR signaling, fa...

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Detalles Bibliográficos
Autores principales: Birkisdóttir, María B., Jaarsma, Dick, Brandt, Renata M. C., Barnhoorn, Sander, van Vliet, Nicole, Imholz, Sandra, van Oostrom, Conny T., Nagarajah, Bhawani, Portilla Fernández, Eliana, Roks, Anton J. M., Elgersma, Ype, van Steeg, Harry, Ferreira, José A., Pennings, Jeroen L. A., Hoeijmakers, Jan H. J., Vermeij, Wilbert P., Dollé, Martijn E. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884048/
https://www.ncbi.nlm.nih.gov/pubmed/33484480
http://dx.doi.org/10.1111/acel.13302

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