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Glycemic fluctuations caused by COVID-19: Results from continuous glucose monitoring
AIM: We aimed to address the potential impact of COVID-19 on glycemic patterns in a small pilot study. METHOD: 13 patients with mild COVID-19 who were confirmed without diabetes and another group of 18 healthy individuals with available CGM data were well matched and enrolled into the final analysis...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Ltd.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884232/ https://www.ncbi.nlm.nih.gov/pubmed/33615034 http://dx.doi.org/10.1016/j.obmed.2021.100328 |
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author | Shen, Yun Zhang, Lei Fan, Xiaohong Zhou, Jian |
author_facet | Shen, Yun Zhang, Lei Fan, Xiaohong Zhou, Jian |
author_sort | Shen, Yun |
collection | PubMed |
description | AIM: We aimed to address the potential impact of COVID-19 on glycemic patterns in a small pilot study. METHOD: 13 patients with mild COVID-19 who were confirmed without diabetes and another group of 18 healthy individuals with available CGM data were well matched and enrolled into the final analysis. RESULTS: We noticed significantly higher TARs of >140 mg/dL (median 13.9% vs. 2.3%, P = 0.006), >160 mg/dL (median 4.7% vs. 0.0%, P = 0.011) and >180 mg/dL (median 1.9% vs. 0.0%, P = 0.007) among non-diabetic patients with COVID-19 than those among healthy individuals. There was no significant difference in TBR of <70 mg/dL or <54 mg/dL (all P > 0.1). Consequently, the TIR of 70 mg/dL to 140 mg/dL was significantly lower in non-diabetic patients with COVID-19 than that in healthy individuals (median 80.1% vs. 93.1%, P = 0.001). Significant postprandial glycemic fluctuations were observed among patients with COVID-19. There was a remarkable difference in CV in non-diabetic patients with COVID-19 compared to healthy individuals (median 25.6% vs. 15.7%, P < 0.001). CONCLUSION: Significant higher glycemic fluctuation and exposure to hyperglycemia was associated with COVID-19 among previously normoglycemic individuals, characterized with potentially impaired glucose tolerance. |
format | Online Article Text |
id | pubmed-7884232 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78842322021-02-16 Glycemic fluctuations caused by COVID-19: Results from continuous glucose monitoring Shen, Yun Zhang, Lei Fan, Xiaohong Zhou, Jian Obes Med Short Communication AIM: We aimed to address the potential impact of COVID-19 on glycemic patterns in a small pilot study. METHOD: 13 patients with mild COVID-19 who were confirmed without diabetes and another group of 18 healthy individuals with available CGM data were well matched and enrolled into the final analysis. RESULTS: We noticed significantly higher TARs of >140 mg/dL (median 13.9% vs. 2.3%, P = 0.006), >160 mg/dL (median 4.7% vs. 0.0%, P = 0.011) and >180 mg/dL (median 1.9% vs. 0.0%, P = 0.007) among non-diabetic patients with COVID-19 than those among healthy individuals. There was no significant difference in TBR of <70 mg/dL or <54 mg/dL (all P > 0.1). Consequently, the TIR of 70 mg/dL to 140 mg/dL was significantly lower in non-diabetic patients with COVID-19 than that in healthy individuals (median 80.1% vs. 93.1%, P = 0.001). Significant postprandial glycemic fluctuations were observed among patients with COVID-19. There was a remarkable difference in CV in non-diabetic patients with COVID-19 compared to healthy individuals (median 25.6% vs. 15.7%, P < 0.001). CONCLUSION: Significant higher glycemic fluctuation and exposure to hyperglycemia was associated with COVID-19 among previously normoglycemic individuals, characterized with potentially impaired glucose tolerance. Elsevier Ltd. 2021-03 2021-02-16 /pmc/articles/PMC7884232/ /pubmed/33615034 http://dx.doi.org/10.1016/j.obmed.2021.100328 Text en © 2021 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Short Communication Shen, Yun Zhang, Lei Fan, Xiaohong Zhou, Jian Glycemic fluctuations caused by COVID-19: Results from continuous glucose monitoring |
title | Glycemic fluctuations caused by COVID-19: Results from continuous glucose monitoring |
title_full | Glycemic fluctuations caused by COVID-19: Results from continuous glucose monitoring |
title_fullStr | Glycemic fluctuations caused by COVID-19: Results from continuous glucose monitoring |
title_full_unstemmed | Glycemic fluctuations caused by COVID-19: Results from continuous glucose monitoring |
title_short | Glycemic fluctuations caused by COVID-19: Results from continuous glucose monitoring |
title_sort | glycemic fluctuations caused by covid-19: results from continuous glucose monitoring |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884232/ https://www.ncbi.nlm.nih.gov/pubmed/33615034 http://dx.doi.org/10.1016/j.obmed.2021.100328 |
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