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Impact of Arterial Stiffness on All-Cause Mortality in Patients Hospitalized With COVID-19 in Spain
Older age and cardiovascular comorbidities are well-known risk factors for all-cause mortality in patients with coronavirus disease 2019 (COVID-19). Hypertension and age are the 2 principal determinants of arterial stiffness (AS). This study aimed to estimate AS in patients with COVID-19 requiring h...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884247/ https://www.ncbi.nlm.nih.gov/pubmed/33377393 http://dx.doi.org/10.1161/HYPERTENSIONAHA.120.16563 |
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author | Rodilla, Enrique López-Carmona, Maria Dolores Cortes, Xavi Cobos-Palacios, Lidia Canales, Sergio Sáez, Maria Carmen Campos Escudero, Samara Rubio-Rivas, Manuel Díez Manglano, Jesus Freire Castro, Santiago J. Vázquez Piqueras, Nuria Mateo Sanchis, Elisabeth Pesqueira Fontan, Paula Maria Magallanes Gamboa, Jeffrey Oskar González García, Andrés Madrid Romero, Victor Tamargo Chamorro, Lara González Moraleja, Julio Villanueva Martínez, Javier González Noya, Amara Suárez-Lombraña, Ana Gracia Gutiérrez, Anyuli López Reboiro, Manuel Lorenzo Ramos Rincón, José Manuel Gómez Huelgas, Ricardo |
author_facet | Rodilla, Enrique López-Carmona, Maria Dolores Cortes, Xavi Cobos-Palacios, Lidia Canales, Sergio Sáez, Maria Carmen Campos Escudero, Samara Rubio-Rivas, Manuel Díez Manglano, Jesus Freire Castro, Santiago J. Vázquez Piqueras, Nuria Mateo Sanchis, Elisabeth Pesqueira Fontan, Paula Maria Magallanes Gamboa, Jeffrey Oskar González García, Andrés Madrid Romero, Victor Tamargo Chamorro, Lara González Moraleja, Julio Villanueva Martínez, Javier González Noya, Amara Suárez-Lombraña, Ana Gracia Gutiérrez, Anyuli López Reboiro, Manuel Lorenzo Ramos Rincón, José Manuel Gómez Huelgas, Ricardo |
author_sort | Rodilla, Enrique |
collection | PubMed |
description | Older age and cardiovascular comorbidities are well-known risk factors for all-cause mortality in patients with coronavirus disease 2019 (COVID-19). Hypertension and age are the 2 principal determinants of arterial stiffness (AS). This study aimed to estimate AS in patients with COVID-19 requiring hospitalization and analyze its association with all-cause in-hospital mortality. This observational, retrospective, multicenter cohort study analyzed 12 170 patients admitted to 150 Spanish centers included in the SEMI-COVID-19 Network. We compared AS, defined as pulse pressure ≥60 mm Hg, and clinical characteristics between survivors and nonsurvivors. Mean age was 67.5 (±16.1) years and 42.5% were women. Overall, 2606 (21.4%) subjects died. Admission systolic blood pressure (BP) <120 and ≥140 mm Hg was a predictor of higher all-cause mortality (23.5% and 22.8%, respectively, P<0.001), compared with systolic BP between 120 and 140 mm Hg (18.6%). The 4379 patients with AS (36.0%) were older and had higher systolic and lower diastolic BP. Multivariate analysis showed that AS and systolic BP <120 mm Hg significantly and independently predicted all-cause in-hospital mortality (adjusted odds ratio [ORadj]: 1.27, P=0.0001; ORadj: 1.48, P=0.0001, respectively) after adjusting for sex (males, ORadj: 1.6, P=0.0001), age tertiles (second and third tertiles, ORadj: 2.0 and 4.7, P=0.0001), Charlson Comorbidity Index (second and third tertiles, ORadj: 4.8 and 8.6, P=0.0001), heart failure, and previous and in-hospital antihypertensive treatment. Our data show that AS and admission systolic BP <120 mm Hg had independent prognostic value for all-cause mortality in patients with COVID-19 requiring hospitalization. |
format | Online Article Text |
id | pubmed-7884247 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-78842472021-02-22 Impact of Arterial Stiffness on All-Cause Mortality in Patients Hospitalized With COVID-19 in Spain Rodilla, Enrique López-Carmona, Maria Dolores Cortes, Xavi Cobos-Palacios, Lidia Canales, Sergio Sáez, Maria Carmen Campos Escudero, Samara Rubio-Rivas, Manuel Díez Manglano, Jesus Freire Castro, Santiago J. Vázquez Piqueras, Nuria Mateo Sanchis, Elisabeth Pesqueira Fontan, Paula Maria Magallanes Gamboa, Jeffrey Oskar González García, Andrés Madrid Romero, Victor Tamargo Chamorro, Lara González Moraleja, Julio Villanueva Martínez, Javier González Noya, Amara Suárez-Lombraña, Ana Gracia Gutiérrez, Anyuli López Reboiro, Manuel Lorenzo Ramos Rincón, José Manuel Gómez Huelgas, Ricardo Hypertension Original Articles Older age and cardiovascular comorbidities are well-known risk factors for all-cause mortality in patients with coronavirus disease 2019 (COVID-19). Hypertension and age are the 2 principal determinants of arterial stiffness (AS). This study aimed to estimate AS in patients with COVID-19 requiring hospitalization and analyze its association with all-cause in-hospital mortality. This observational, retrospective, multicenter cohort study analyzed 12 170 patients admitted to 150 Spanish centers included in the SEMI-COVID-19 Network. We compared AS, defined as pulse pressure ≥60 mm Hg, and clinical characteristics between survivors and nonsurvivors. Mean age was 67.5 (±16.1) years and 42.5% were women. Overall, 2606 (21.4%) subjects died. Admission systolic blood pressure (BP) <120 and ≥140 mm Hg was a predictor of higher all-cause mortality (23.5% and 22.8%, respectively, P<0.001), compared with systolic BP between 120 and 140 mm Hg (18.6%). The 4379 patients with AS (36.0%) were older and had higher systolic and lower diastolic BP. Multivariate analysis showed that AS and systolic BP <120 mm Hg significantly and independently predicted all-cause in-hospital mortality (adjusted odds ratio [ORadj]: 1.27, P=0.0001; ORadj: 1.48, P=0.0001, respectively) after adjusting for sex (males, ORadj: 1.6, P=0.0001), age tertiles (second and third tertiles, ORadj: 2.0 and 4.7, P=0.0001), Charlson Comorbidity Index (second and third tertiles, ORadj: 4.8 and 8.6, P=0.0001), heart failure, and previous and in-hospital antihypertensive treatment. Our data show that AS and admission systolic BP <120 mm Hg had independent prognostic value for all-cause mortality in patients with COVID-19 requiring hospitalization. Lippincott Williams & Wilkins 2020-12-30 2021-03-03 /pmc/articles/PMC7884247/ /pubmed/33377393 http://dx.doi.org/10.1161/HYPERTENSIONAHA.120.16563 Text en © 2021 American Heart Association, Inc. This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections. |
spellingShingle | Original Articles Rodilla, Enrique López-Carmona, Maria Dolores Cortes, Xavi Cobos-Palacios, Lidia Canales, Sergio Sáez, Maria Carmen Campos Escudero, Samara Rubio-Rivas, Manuel Díez Manglano, Jesus Freire Castro, Santiago J. Vázquez Piqueras, Nuria Mateo Sanchis, Elisabeth Pesqueira Fontan, Paula Maria Magallanes Gamboa, Jeffrey Oskar González García, Andrés Madrid Romero, Victor Tamargo Chamorro, Lara González Moraleja, Julio Villanueva Martínez, Javier González Noya, Amara Suárez-Lombraña, Ana Gracia Gutiérrez, Anyuli López Reboiro, Manuel Lorenzo Ramos Rincón, José Manuel Gómez Huelgas, Ricardo Impact of Arterial Stiffness on All-Cause Mortality in Patients Hospitalized With COVID-19 in Spain |
title | Impact of Arterial Stiffness on All-Cause Mortality in Patients Hospitalized With COVID-19 in Spain |
title_full | Impact of Arterial Stiffness on All-Cause Mortality in Patients Hospitalized With COVID-19 in Spain |
title_fullStr | Impact of Arterial Stiffness on All-Cause Mortality in Patients Hospitalized With COVID-19 in Spain |
title_full_unstemmed | Impact of Arterial Stiffness on All-Cause Mortality in Patients Hospitalized With COVID-19 in Spain |
title_short | Impact of Arterial Stiffness on All-Cause Mortality in Patients Hospitalized With COVID-19 in Spain |
title_sort | impact of arterial stiffness on all-cause mortality in patients hospitalized with covid-19 in spain |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884247/ https://www.ncbi.nlm.nih.gov/pubmed/33377393 http://dx.doi.org/10.1161/HYPERTENSIONAHA.120.16563 |
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