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Impact of Arterial Stiffness on All-Cause Mortality in Patients Hospitalized With COVID-19 in Spain

Older age and cardiovascular comorbidities are well-known risk factors for all-cause mortality in patients with coronavirus disease 2019 (COVID-19). Hypertension and age are the 2 principal determinants of arterial stiffness (AS). This study aimed to estimate AS in patients with COVID-19 requiring h...

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Autores principales: Rodilla, Enrique, López-Carmona, Maria Dolores, Cortes, Xavi, Cobos-Palacios, Lidia, Canales, Sergio, Sáez, Maria Carmen, Campos Escudero, Samara, Rubio-Rivas, Manuel, Díez Manglano, Jesus, Freire Castro, Santiago J., Vázquez Piqueras, Nuria, Mateo Sanchis, Elisabeth, Pesqueira Fontan, Paula Maria, Magallanes Gamboa, Jeffrey Oskar, González García, Andrés, Madrid Romero, Victor, Tamargo Chamorro, Lara, González Moraleja, Julio, Villanueva Martínez, Javier, González Noya, Amara, Suárez-Lombraña, Ana, Gracia Gutiérrez, Anyuli, López Reboiro, Manuel Lorenzo, Ramos Rincón, José Manuel, Gómez Huelgas, Ricardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884247/
https://www.ncbi.nlm.nih.gov/pubmed/33377393
http://dx.doi.org/10.1161/HYPERTENSIONAHA.120.16563
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author Rodilla, Enrique
López-Carmona, Maria Dolores
Cortes, Xavi
Cobos-Palacios, Lidia
Canales, Sergio
Sáez, Maria Carmen
Campos Escudero, Samara
Rubio-Rivas, Manuel
Díez Manglano, Jesus
Freire Castro, Santiago J.
Vázquez Piqueras, Nuria
Mateo Sanchis, Elisabeth
Pesqueira Fontan, Paula Maria
Magallanes Gamboa, Jeffrey Oskar
González García, Andrés
Madrid Romero, Victor
Tamargo Chamorro, Lara
González Moraleja, Julio
Villanueva Martínez, Javier
González Noya, Amara
Suárez-Lombraña, Ana
Gracia Gutiérrez, Anyuli
López Reboiro, Manuel Lorenzo
Ramos Rincón, José Manuel
Gómez Huelgas, Ricardo
author_facet Rodilla, Enrique
López-Carmona, Maria Dolores
Cortes, Xavi
Cobos-Palacios, Lidia
Canales, Sergio
Sáez, Maria Carmen
Campos Escudero, Samara
Rubio-Rivas, Manuel
Díez Manglano, Jesus
Freire Castro, Santiago J.
Vázquez Piqueras, Nuria
Mateo Sanchis, Elisabeth
Pesqueira Fontan, Paula Maria
Magallanes Gamboa, Jeffrey Oskar
González García, Andrés
Madrid Romero, Victor
Tamargo Chamorro, Lara
González Moraleja, Julio
Villanueva Martínez, Javier
González Noya, Amara
Suárez-Lombraña, Ana
Gracia Gutiérrez, Anyuli
López Reboiro, Manuel Lorenzo
Ramos Rincón, José Manuel
Gómez Huelgas, Ricardo
author_sort Rodilla, Enrique
collection PubMed
description Older age and cardiovascular comorbidities are well-known risk factors for all-cause mortality in patients with coronavirus disease 2019 (COVID-19). Hypertension and age are the 2 principal determinants of arterial stiffness (AS). This study aimed to estimate AS in patients with COVID-19 requiring hospitalization and analyze its association with all-cause in-hospital mortality. This observational, retrospective, multicenter cohort study analyzed 12 170 patients admitted to 150 Spanish centers included in the SEMI-COVID-19 Network. We compared AS, defined as pulse pressure ≥60 mm Hg, and clinical characteristics between survivors and nonsurvivors. Mean age was 67.5 (±16.1) years and 42.5% were women. Overall, 2606 (21.4%) subjects died. Admission systolic blood pressure (BP) <120 and ≥140 mm Hg was a predictor of higher all-cause mortality (23.5% and 22.8%, respectively, P<0.001), compared with systolic BP between 120 and 140 mm Hg (18.6%). The 4379 patients with AS (36.0%) were older and had higher systolic and lower diastolic BP. Multivariate analysis showed that AS and systolic BP <120 mm Hg significantly and independently predicted all-cause in-hospital mortality (adjusted odds ratio [ORadj]: 1.27, P=0.0001; ORadj: 1.48, P=0.0001, respectively) after adjusting for sex (males, ORadj: 1.6, P=0.0001), age tertiles (second and third tertiles, ORadj: 2.0 and 4.7, P=0.0001), Charlson Comorbidity Index (second and third tertiles, ORadj: 4.8 and 8.6, P=0.0001), heart failure, and previous and in-hospital antihypertensive treatment. Our data show that AS and admission systolic BP <120 mm Hg had independent prognostic value for all-cause mortality in patients with COVID-19 requiring hospitalization.
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spelling pubmed-78842472021-02-22 Impact of Arterial Stiffness on All-Cause Mortality in Patients Hospitalized With COVID-19 in Spain Rodilla, Enrique López-Carmona, Maria Dolores Cortes, Xavi Cobos-Palacios, Lidia Canales, Sergio Sáez, Maria Carmen Campos Escudero, Samara Rubio-Rivas, Manuel Díez Manglano, Jesus Freire Castro, Santiago J. Vázquez Piqueras, Nuria Mateo Sanchis, Elisabeth Pesqueira Fontan, Paula Maria Magallanes Gamboa, Jeffrey Oskar González García, Andrés Madrid Romero, Victor Tamargo Chamorro, Lara González Moraleja, Julio Villanueva Martínez, Javier González Noya, Amara Suárez-Lombraña, Ana Gracia Gutiérrez, Anyuli López Reboiro, Manuel Lorenzo Ramos Rincón, José Manuel Gómez Huelgas, Ricardo Hypertension Original Articles Older age and cardiovascular comorbidities are well-known risk factors for all-cause mortality in patients with coronavirus disease 2019 (COVID-19). Hypertension and age are the 2 principal determinants of arterial stiffness (AS). This study aimed to estimate AS in patients with COVID-19 requiring hospitalization and analyze its association with all-cause in-hospital mortality. This observational, retrospective, multicenter cohort study analyzed 12 170 patients admitted to 150 Spanish centers included in the SEMI-COVID-19 Network. We compared AS, defined as pulse pressure ≥60 mm Hg, and clinical characteristics between survivors and nonsurvivors. Mean age was 67.5 (±16.1) years and 42.5% were women. Overall, 2606 (21.4%) subjects died. Admission systolic blood pressure (BP) <120 and ≥140 mm Hg was a predictor of higher all-cause mortality (23.5% and 22.8%, respectively, P<0.001), compared with systolic BP between 120 and 140 mm Hg (18.6%). The 4379 patients with AS (36.0%) were older and had higher systolic and lower diastolic BP. Multivariate analysis showed that AS and systolic BP <120 mm Hg significantly and independently predicted all-cause in-hospital mortality (adjusted odds ratio [ORadj]: 1.27, P=0.0001; ORadj: 1.48, P=0.0001, respectively) after adjusting for sex (males, ORadj: 1.6, P=0.0001), age tertiles (second and third tertiles, ORadj: 2.0 and 4.7, P=0.0001), Charlson Comorbidity Index (second and third tertiles, ORadj: 4.8 and 8.6, P=0.0001), heart failure, and previous and in-hospital antihypertensive treatment. Our data show that AS and admission systolic BP <120 mm Hg had independent prognostic value for all-cause mortality in patients with COVID-19 requiring hospitalization. Lippincott Williams & Wilkins 2020-12-30 2021-03-03 /pmc/articles/PMC7884247/ /pubmed/33377393 http://dx.doi.org/10.1161/HYPERTENSIONAHA.120.16563 Text en © 2021 American Heart Association, Inc. This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.
spellingShingle Original Articles
Rodilla, Enrique
López-Carmona, Maria Dolores
Cortes, Xavi
Cobos-Palacios, Lidia
Canales, Sergio
Sáez, Maria Carmen
Campos Escudero, Samara
Rubio-Rivas, Manuel
Díez Manglano, Jesus
Freire Castro, Santiago J.
Vázquez Piqueras, Nuria
Mateo Sanchis, Elisabeth
Pesqueira Fontan, Paula Maria
Magallanes Gamboa, Jeffrey Oskar
González García, Andrés
Madrid Romero, Victor
Tamargo Chamorro, Lara
González Moraleja, Julio
Villanueva Martínez, Javier
González Noya, Amara
Suárez-Lombraña, Ana
Gracia Gutiérrez, Anyuli
López Reboiro, Manuel Lorenzo
Ramos Rincón, José Manuel
Gómez Huelgas, Ricardo
Impact of Arterial Stiffness on All-Cause Mortality in Patients Hospitalized With COVID-19 in Spain
title Impact of Arterial Stiffness on All-Cause Mortality in Patients Hospitalized With COVID-19 in Spain
title_full Impact of Arterial Stiffness on All-Cause Mortality in Patients Hospitalized With COVID-19 in Spain
title_fullStr Impact of Arterial Stiffness on All-Cause Mortality in Patients Hospitalized With COVID-19 in Spain
title_full_unstemmed Impact of Arterial Stiffness on All-Cause Mortality in Patients Hospitalized With COVID-19 in Spain
title_short Impact of Arterial Stiffness on All-Cause Mortality in Patients Hospitalized With COVID-19 in Spain
title_sort impact of arterial stiffness on all-cause mortality in patients hospitalized with covid-19 in spain
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884247/
https://www.ncbi.nlm.nih.gov/pubmed/33377393
http://dx.doi.org/10.1161/HYPERTENSIONAHA.120.16563
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