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Use of transcranial magnetic stimulation to assess relaxation rates in unfatigued and fatigued knee-extensor muscles
We examined whether transcranial magnetic stimulation (TMS) delivered to the motor cortex allows assessment of muscle relaxation rates in unfatigued and fatigued knee extensors (KE). We assessed the ability of this technique to measure time course of fatigue-induced changes in muscle relaxation rate...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884370/ https://www.ncbi.nlm.nih.gov/pubmed/33140192 http://dx.doi.org/10.1007/s00221-020-05921-9 |
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author | Vernillo, Gianluca Khassetarash, Arash Millet, Guillaume Y. Temesi, John |
author_facet | Vernillo, Gianluca Khassetarash, Arash Millet, Guillaume Y. Temesi, John |
author_sort | Vernillo, Gianluca |
collection | PubMed |
description | We examined whether transcranial magnetic stimulation (TMS) delivered to the motor cortex allows assessment of muscle relaxation rates in unfatigued and fatigued knee extensors (KE). We assessed the ability of this technique to measure time course of fatigue-induced changes in muscle relaxation rate and compared relaxation rate from resting twitches evoked by femoral nerve stimulation. Twelve healthy men performed maximal voluntary isometric contractions (MVC) twice before (PRE) and once at the end of a 2-min KE MVC and five more times within 8 min during recovery. Relative (intraclass correlation coefficient; ICC(2,1)) and absolute (repeatability coefficient) reliability and variability (coefficient of variation) were assessed. Time course of fatigue-induced changes in muscle relaxation rate was tested with generalized estimating equations. In unfatigued KE, peak relaxation rate coefficient of variation and repeatability coefficient were similar for both techniques. Mean (95% CI) ICC(2,1) for peak relaxation rates were 0.933 (0.724–0.982) and 0.889 (0.603–0.968) for TMS and femoral nerve stimulation, respectively. TMS-induced normalized muscle relaxation rate was − 11.5 ± 2.5 s(−1) at PRE, decreased to − 6.9 ± 1.2 s(−1) (− 37 ± 17%, P < 0.001), and recovered by 2 min post-exercise. Normalized peak relaxation rate for resting twitch did not show a fatigue-induced change. During fatiguing KE exercise, the change in muscle relaxation rate as determined by the two techniques was different. TMS provides reliable values of muscle relaxation rates. Furthermore, it is sufficiently sensitive and more appropriate than the resting twitch evoked by femoral nerve stimulation to reveal fatigue-induced changes in KE. |
format | Online Article Text |
id | pubmed-7884370 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-78843702021-02-25 Use of transcranial magnetic stimulation to assess relaxation rates in unfatigued and fatigued knee-extensor muscles Vernillo, Gianluca Khassetarash, Arash Millet, Guillaume Y. Temesi, John Exp Brain Res Research Article We examined whether transcranial magnetic stimulation (TMS) delivered to the motor cortex allows assessment of muscle relaxation rates in unfatigued and fatigued knee extensors (KE). We assessed the ability of this technique to measure time course of fatigue-induced changes in muscle relaxation rate and compared relaxation rate from resting twitches evoked by femoral nerve stimulation. Twelve healthy men performed maximal voluntary isometric contractions (MVC) twice before (PRE) and once at the end of a 2-min KE MVC and five more times within 8 min during recovery. Relative (intraclass correlation coefficient; ICC(2,1)) and absolute (repeatability coefficient) reliability and variability (coefficient of variation) were assessed. Time course of fatigue-induced changes in muscle relaxation rate was tested with generalized estimating equations. In unfatigued KE, peak relaxation rate coefficient of variation and repeatability coefficient were similar for both techniques. Mean (95% CI) ICC(2,1) for peak relaxation rates were 0.933 (0.724–0.982) and 0.889 (0.603–0.968) for TMS and femoral nerve stimulation, respectively. TMS-induced normalized muscle relaxation rate was − 11.5 ± 2.5 s(−1) at PRE, decreased to − 6.9 ± 1.2 s(−1) (− 37 ± 17%, P < 0.001), and recovered by 2 min post-exercise. Normalized peak relaxation rate for resting twitch did not show a fatigue-induced change. During fatiguing KE exercise, the change in muscle relaxation rate as determined by the two techniques was different. TMS provides reliable values of muscle relaxation rates. Furthermore, it is sufficiently sensitive and more appropriate than the resting twitch evoked by femoral nerve stimulation to reveal fatigue-induced changes in KE. Springer Berlin Heidelberg 2020-11-02 2021 /pmc/articles/PMC7884370/ /pubmed/33140192 http://dx.doi.org/10.1007/s00221-020-05921-9 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Vernillo, Gianluca Khassetarash, Arash Millet, Guillaume Y. Temesi, John Use of transcranial magnetic stimulation to assess relaxation rates in unfatigued and fatigued knee-extensor muscles |
title | Use of transcranial magnetic stimulation to assess relaxation rates in unfatigued and fatigued knee-extensor muscles |
title_full | Use of transcranial magnetic stimulation to assess relaxation rates in unfatigued and fatigued knee-extensor muscles |
title_fullStr | Use of transcranial magnetic stimulation to assess relaxation rates in unfatigued and fatigued knee-extensor muscles |
title_full_unstemmed | Use of transcranial magnetic stimulation to assess relaxation rates in unfatigued and fatigued knee-extensor muscles |
title_short | Use of transcranial magnetic stimulation to assess relaxation rates in unfatigued and fatigued knee-extensor muscles |
title_sort | use of transcranial magnetic stimulation to assess relaxation rates in unfatigued and fatigued knee-extensor muscles |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884370/ https://www.ncbi.nlm.nih.gov/pubmed/33140192 http://dx.doi.org/10.1007/s00221-020-05921-9 |
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