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HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones

Upon binding to DNA breaks, poly(ADP-ribose) polymerase 1 (PARP1) ADP-ribosylates itself and other factors to initiate DNA repair. Serine is the major residue for ADP-ribosylation upon DNA damage, which strictly depends on HPF1. Here, we report the crystal structures of human HPF1/PARP1-CAT ΔHD comp...

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Detalles Bibliográficos
Autores principales:	Sun, Fa-Hui, Zhao, Peng, Zhang, Nan, Kong, Lu-Lu, Wong, Catherine C. L., Yun, Cai-Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884425/ https://www.ncbi.nlm.nih.gov/pubmed/33589610 http://dx.doi.org/10.1038/s41467-021-21302-4

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