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Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study
Enterovirus and adenovirus infections have been linked to the development of celiac disease. We evaluated this association in children who developed biopsy-proven celiac disease (N = 41) during prospective observation starting from birth, and in control children (N = 53) matched for the calendar tim...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884453/ https://www.ncbi.nlm.nih.gov/pubmed/33603739 http://dx.doi.org/10.3389/fimmu.2020.604529 |
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author | Oikarinen, Maarit Puustinen, Leena Lehtonen, Jussi Hakola, Leena Simell, Satu Toppari, Jorma Ilonen, Jorma Veijola, Riitta Virtanen, Suvi M. Knip, Mikael Hyöty, Heikki |
author_facet | Oikarinen, Maarit Puustinen, Leena Lehtonen, Jussi Hakola, Leena Simell, Satu Toppari, Jorma Ilonen, Jorma Veijola, Riitta Virtanen, Suvi M. Knip, Mikael Hyöty, Heikki |
author_sort | Oikarinen, Maarit |
collection | PubMed |
description | Enterovirus and adenovirus infections have been linked to the development of celiac disease. We evaluated this association in children who developed biopsy-proven celiac disease (N = 41) during prospective observation starting from birth, and in control children (N = 53) matched for the calendar time of birth, sex, and HLA-DQ genotype. Enterovirus and adenovirus infections were diagnosed by seroconversions in virus antibodies in longitudinally collected sera using EIA. Enterovirus infections were more frequent in case children before the appearance of celiac disease-associated tissue transglutaminase autoantibodies compared to the corresponding period in control children (OR 6.3, 95% CI 1.8–22.3; p = 0.005). No difference was observed in the frequency of adenovirus infections. The findings suggest that enterovirus infections may contribute to the process leading to celiac disease. |
format | Online Article Text |
id | pubmed-7884453 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78844532021-02-17 Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study Oikarinen, Maarit Puustinen, Leena Lehtonen, Jussi Hakola, Leena Simell, Satu Toppari, Jorma Ilonen, Jorma Veijola, Riitta Virtanen, Suvi M. Knip, Mikael Hyöty, Heikki Front Immunol Immunology Enterovirus and adenovirus infections have been linked to the development of celiac disease. We evaluated this association in children who developed biopsy-proven celiac disease (N = 41) during prospective observation starting from birth, and in control children (N = 53) matched for the calendar time of birth, sex, and HLA-DQ genotype. Enterovirus and adenovirus infections were diagnosed by seroconversions in virus antibodies in longitudinally collected sera using EIA. Enterovirus infections were more frequent in case children before the appearance of celiac disease-associated tissue transglutaminase autoantibodies compared to the corresponding period in control children (OR 6.3, 95% CI 1.8–22.3; p = 0.005). No difference was observed in the frequency of adenovirus infections. The findings suggest that enterovirus infections may contribute to the process leading to celiac disease. Frontiers Media S.A. 2021-02-02 /pmc/articles/PMC7884453/ /pubmed/33603739 http://dx.doi.org/10.3389/fimmu.2020.604529 Text en Copyright © 2021 Oikarinen, Puustinen, Lehtonen, Hakola, Simell, Toppari, Ilonen, Veijola, Virtanen, Knip and Hyöty http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Oikarinen, Maarit Puustinen, Leena Lehtonen, Jussi Hakola, Leena Simell, Satu Toppari, Jorma Ilonen, Jorma Veijola, Riitta Virtanen, Suvi M. Knip, Mikael Hyöty, Heikki Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study |
title | Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study |
title_full | Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study |
title_fullStr | Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study |
title_full_unstemmed | Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study |
title_short | Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study |
title_sort | enterovirus infections are associated with the development of celiac disease in a birth cohort study |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884453/ https://www.ncbi.nlm.nih.gov/pubmed/33603739 http://dx.doi.org/10.3389/fimmu.2020.604529 |
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