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Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study

Enterovirus and adenovirus infections have been linked to the development of celiac disease. We evaluated this association in children who developed biopsy-proven celiac disease (N = 41) during prospective observation starting from birth, and in control children (N = 53) matched for the calendar tim...

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Autores principales: Oikarinen, Maarit, Puustinen, Leena, Lehtonen, Jussi, Hakola, Leena, Simell, Satu, Toppari, Jorma, Ilonen, Jorma, Veijola, Riitta, Virtanen, Suvi M., Knip, Mikael, Hyöty, Heikki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884453/
https://www.ncbi.nlm.nih.gov/pubmed/33603739
http://dx.doi.org/10.3389/fimmu.2020.604529
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author Oikarinen, Maarit
Puustinen, Leena
Lehtonen, Jussi
Hakola, Leena
Simell, Satu
Toppari, Jorma
Ilonen, Jorma
Veijola, Riitta
Virtanen, Suvi M.
Knip, Mikael
Hyöty, Heikki
author_facet Oikarinen, Maarit
Puustinen, Leena
Lehtonen, Jussi
Hakola, Leena
Simell, Satu
Toppari, Jorma
Ilonen, Jorma
Veijola, Riitta
Virtanen, Suvi M.
Knip, Mikael
Hyöty, Heikki
author_sort Oikarinen, Maarit
collection PubMed
description Enterovirus and adenovirus infections have been linked to the development of celiac disease. We evaluated this association in children who developed biopsy-proven celiac disease (N = 41) during prospective observation starting from birth, and in control children (N = 53) matched for the calendar time of birth, sex, and HLA-DQ genotype. Enterovirus and adenovirus infections were diagnosed by seroconversions in virus antibodies in longitudinally collected sera using EIA. Enterovirus infections were more frequent in case children before the appearance of celiac disease-associated tissue transglutaminase autoantibodies compared to the corresponding period in control children (OR 6.3, 95% CI 1.8–22.3; p = 0.005). No difference was observed in the frequency of adenovirus infections. The findings suggest that enterovirus infections may contribute to the process leading to celiac disease.
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spelling pubmed-78844532021-02-17 Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study Oikarinen, Maarit Puustinen, Leena Lehtonen, Jussi Hakola, Leena Simell, Satu Toppari, Jorma Ilonen, Jorma Veijola, Riitta Virtanen, Suvi M. Knip, Mikael Hyöty, Heikki Front Immunol Immunology Enterovirus and adenovirus infections have been linked to the development of celiac disease. We evaluated this association in children who developed biopsy-proven celiac disease (N = 41) during prospective observation starting from birth, and in control children (N = 53) matched for the calendar time of birth, sex, and HLA-DQ genotype. Enterovirus and adenovirus infections were diagnosed by seroconversions in virus antibodies in longitudinally collected sera using EIA. Enterovirus infections were more frequent in case children before the appearance of celiac disease-associated tissue transglutaminase autoantibodies compared to the corresponding period in control children (OR 6.3, 95% CI 1.8–22.3; p = 0.005). No difference was observed in the frequency of adenovirus infections. The findings suggest that enterovirus infections may contribute to the process leading to celiac disease. Frontiers Media S.A. 2021-02-02 /pmc/articles/PMC7884453/ /pubmed/33603739 http://dx.doi.org/10.3389/fimmu.2020.604529 Text en Copyright © 2021 Oikarinen, Puustinen, Lehtonen, Hakola, Simell, Toppari, Ilonen, Veijola, Virtanen, Knip and Hyöty http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Oikarinen, Maarit
Puustinen, Leena
Lehtonen, Jussi
Hakola, Leena
Simell, Satu
Toppari, Jorma
Ilonen, Jorma
Veijola, Riitta
Virtanen, Suvi M.
Knip, Mikael
Hyöty, Heikki
Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study
title Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study
title_full Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study
title_fullStr Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study
title_full_unstemmed Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study
title_short Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study
title_sort enterovirus infections are associated with the development of celiac disease in a birth cohort study
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884453/
https://www.ncbi.nlm.nih.gov/pubmed/33603739
http://dx.doi.org/10.3389/fimmu.2020.604529
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