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Longitudinal deterioration of white-matter integrity: heterogeneity in the ageing population

Deterioration in white-matter health plays a role in cognitive ageing. Our goal was to discern heterogeneity of white-matter tract vulnerability in ageing using longitudinal imaging data (two to five imaging and cognitive assessments per participant) from a population-based sample of 553 elderly par...

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Autores principales: Poulakis, Konstantinos, Reid, Robert I, Przybelski, Scott A, Knopman, David S, Graff-Radford, Jonathan, Lowe, Val J, Mielke, Michelle M, Machulda, Mary M, Jack, Clifford R, Petersen, Ronald C, Westman, Eric, Vemuri, Prashanthi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884606/
https://www.ncbi.nlm.nih.gov/pubmed/33615218
http://dx.doi.org/10.1093/braincomms/fcaa238
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author Poulakis, Konstantinos
Reid, Robert I
Przybelski, Scott A
Knopman, David S
Graff-Radford, Jonathan
Lowe, Val J
Mielke, Michelle M
Machulda, Mary M
Jack, Clifford R
Petersen, Ronald C
Westman, Eric
Vemuri, Prashanthi
author_facet Poulakis, Konstantinos
Reid, Robert I
Przybelski, Scott A
Knopman, David S
Graff-Radford, Jonathan
Lowe, Val J
Mielke, Michelle M
Machulda, Mary M
Jack, Clifford R
Petersen, Ronald C
Westman, Eric
Vemuri, Prashanthi
author_sort Poulakis, Konstantinos
collection PubMed
description Deterioration in white-matter health plays a role in cognitive ageing. Our goal was to discern heterogeneity of white-matter tract vulnerability in ageing using longitudinal imaging data (two to five imaging and cognitive assessments per participant) from a population-based sample of 553 elderly participants (age ≥60 years). We found that different clusters (healthy white matter, fast white-matter decliners and intermediate white-matter group) were heterogeneous in the spatial distribution of white-matter integrity, systemic health and cognitive trajectories. White-matter health of specific tracts (genu of corpus callosum, posterior corona radiata and anterior internal capsule) informed about cluster assignments. Not surprisingly, brain amyloidosis was not significantly different between clusters. Clusters had differential white-matter tract vulnerability to ageing (commissural fibres > association/brainstem fibres). Identification of vulnerable white-matter tracts is a valuable approach to assessing risk for cognitive decline.
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spelling pubmed-78846062021-02-19 Longitudinal deterioration of white-matter integrity: heterogeneity in the ageing population Poulakis, Konstantinos Reid, Robert I Przybelski, Scott A Knopman, David S Graff-Radford, Jonathan Lowe, Val J Mielke, Michelle M Machulda, Mary M Jack, Clifford R Petersen, Ronald C Westman, Eric Vemuri, Prashanthi Brain Commun Original Article Deterioration in white-matter health plays a role in cognitive ageing. Our goal was to discern heterogeneity of white-matter tract vulnerability in ageing using longitudinal imaging data (two to five imaging and cognitive assessments per participant) from a population-based sample of 553 elderly participants (age ≥60 years). We found that different clusters (healthy white matter, fast white-matter decliners and intermediate white-matter group) were heterogeneous in the spatial distribution of white-matter integrity, systemic health and cognitive trajectories. White-matter health of specific tracts (genu of corpus callosum, posterior corona radiata and anterior internal capsule) informed about cluster assignments. Not surprisingly, brain amyloidosis was not significantly different between clusters. Clusters had differential white-matter tract vulnerability to ageing (commissural fibres > association/brainstem fibres). Identification of vulnerable white-matter tracts is a valuable approach to assessing risk for cognitive decline. Oxford University Press 2021-01-22 /pmc/articles/PMC7884606/ /pubmed/33615218 http://dx.doi.org/10.1093/braincomms/fcaa238 Text en © The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Poulakis, Konstantinos
Reid, Robert I
Przybelski, Scott A
Knopman, David S
Graff-Radford, Jonathan
Lowe, Val J
Mielke, Michelle M
Machulda, Mary M
Jack, Clifford R
Petersen, Ronald C
Westman, Eric
Vemuri, Prashanthi
Longitudinal deterioration of white-matter integrity: heterogeneity in the ageing population
title Longitudinal deterioration of white-matter integrity: heterogeneity in the ageing population
title_full Longitudinal deterioration of white-matter integrity: heterogeneity in the ageing population
title_fullStr Longitudinal deterioration of white-matter integrity: heterogeneity in the ageing population
title_full_unstemmed Longitudinal deterioration of white-matter integrity: heterogeneity in the ageing population
title_short Longitudinal deterioration of white-matter integrity: heterogeneity in the ageing population
title_sort longitudinal deterioration of white-matter integrity: heterogeneity in the ageing population
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884606/
https://www.ncbi.nlm.nih.gov/pubmed/33615218
http://dx.doi.org/10.1093/braincomms/fcaa238
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