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The Role of T Cell Receptor Signaling in the Development of Type 1 Diabetes
T cell receptor (TCR) signaling influences multiple aspects of CD4(+) and CD8(+) T cell immunobiology including thymic development, peripheral homeostasis, effector subset differentiation/function, and memory formation. Additional T cell signaling cues triggered by co-stimulatory molecules and cytok...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884625/ https://www.ncbi.nlm.nih.gov/pubmed/33603744 http://dx.doi.org/10.3389/fimmu.2020.615371 |
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author | Clark, Matthew Kroger, Charles J. Ke, Qi Tisch, Roland M. |
author_facet | Clark, Matthew Kroger, Charles J. Ke, Qi Tisch, Roland M. |
author_sort | Clark, Matthew |
collection | PubMed |
description | T cell receptor (TCR) signaling influences multiple aspects of CD4(+) and CD8(+) T cell immunobiology including thymic development, peripheral homeostasis, effector subset differentiation/function, and memory formation. Additional T cell signaling cues triggered by co-stimulatory molecules and cytokines also affect TCR signaling duration, as well as accessory pathways that further shape a T cell response. Type 1 diabetes (T1D) is a T cell-driven autoimmune disease targeting the insulin producing β cells in the pancreas. Evidence indicates that dysregulated TCR signaling events in T1D impact the efficacy of central and peripheral tolerance-inducing mechanisms. In this review, we will discuss how the strength and nature of TCR signaling events influence the development of self-reactive T cells and drive the progression of T1D through effects on T cell gene expression, lineage commitment, and maintenance of pathogenic anti-self T cell effector function. |
format | Online Article Text |
id | pubmed-7884625 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78846252021-02-17 The Role of T Cell Receptor Signaling in the Development of Type 1 Diabetes Clark, Matthew Kroger, Charles J. Ke, Qi Tisch, Roland M. Front Immunol Immunology T cell receptor (TCR) signaling influences multiple aspects of CD4(+) and CD8(+) T cell immunobiology including thymic development, peripheral homeostasis, effector subset differentiation/function, and memory formation. Additional T cell signaling cues triggered by co-stimulatory molecules and cytokines also affect TCR signaling duration, as well as accessory pathways that further shape a T cell response. Type 1 diabetes (T1D) is a T cell-driven autoimmune disease targeting the insulin producing β cells in the pancreas. Evidence indicates that dysregulated TCR signaling events in T1D impact the efficacy of central and peripheral tolerance-inducing mechanisms. In this review, we will discuss how the strength and nature of TCR signaling events influence the development of self-reactive T cells and drive the progression of T1D through effects on T cell gene expression, lineage commitment, and maintenance of pathogenic anti-self T cell effector function. Frontiers Media S.A. 2021-02-02 /pmc/articles/PMC7884625/ /pubmed/33603744 http://dx.doi.org/10.3389/fimmu.2020.615371 Text en Copyright © 2021 Clark, Kroger, Ke and Tisch http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Clark, Matthew Kroger, Charles J. Ke, Qi Tisch, Roland M. The Role of T Cell Receptor Signaling in the Development of Type 1 Diabetes |
title | The Role of T Cell Receptor Signaling in the Development of Type 1 Diabetes |
title_full | The Role of T Cell Receptor Signaling in the Development of Type 1 Diabetes |
title_fullStr | The Role of T Cell Receptor Signaling in the Development of Type 1 Diabetes |
title_full_unstemmed | The Role of T Cell Receptor Signaling in the Development of Type 1 Diabetes |
title_short | The Role of T Cell Receptor Signaling in the Development of Type 1 Diabetes |
title_sort | role of t cell receptor signaling in the development of type 1 diabetes |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884625/ https://www.ncbi.nlm.nih.gov/pubmed/33603744 http://dx.doi.org/10.3389/fimmu.2020.615371 |
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