Cargando…

Targeting cancer stem cells for reversing therapy resistance: mechanism, signaling, and prospective agents

Cancer stem cells (CSCs) show a self-renewal capacity and differentiation potential that contribute to tumor progression and therapy resistance. However, the underlying processes are still unclear. Elucidation of the key hallmarks and resistance mechanisms of CSCs may help improve patient outcomes a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, He-Ming, Zhang, Ji-Gang, Zhang, Xue, Li, Qin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884707/ https://www.ncbi.nlm.nih.gov/pubmed/33589595 http://dx.doi.org/10.1038/s41392-020-00430-1

Ejemplares similares

Multidrug Resistance of Gastric Cancer: The Mechanisms and Chinese Medicine Reversal Agents
por: Huang, Wen-Jie, et al.
Publicado: (2020)

Therapy resistance in neuroblastoma: Mechanisms and reversal strategies
por: Zhou, Xia, et al.
Publicado: (2023)

Characterization of the mechanism of Scutellaria baicalensis on reversing radio-resistance in colorectal cancer
por: Huang, Jinmei, et al.
Publicado: (2022)

Enhancing CAR T-cell therapies against solid tumors: Mechanisms and reversion of resistance
por: Qin, Yue, et al.
Publicado: (2022)

CAR‐T therapy: Prospects in targeting cancer stem cells
por: Cui, Xiaoyue, et al.
Publicado: (2021)

MET Signaling Pathways, Resistance Mechanisms, and Opportunities for Target Therapies
por: Rivas, Solange, et al.
Publicado: (2022)

Emerging agents that target signaling pathways in cancer stem cells
por: Yang, Yue, et al.
Publicado: (2020)

Resistance to anti-EGFR therapies in metastatic colorectal cancer: underlying mechanisms and reversal strategies
por: Zhou, Jing, et al.
Publicado: (2021)

Reverse Engineering of Free-Form Surface Based on the Closed-Loop Theory
por: He, Xue Ming, et al.
Publicado: (2015)

Arsenic reverses glioblastoma resistance to mTOR-targeted therapies
por: Iwanami, Akio, et al.
Publicado: (2013)

Targeting myeloid chemotaxis to reverse prostate cancer therapy resistance
por: Guo, Christina, et al.
Publicado: (2023)

Targeting of VPS18 by the lysosomotropic agent RDN reverses TFE3-mediated drug resistance
por: Niu, Huanmin, et al.
Publicado: (2021)

Cancer Stem Cells: A Potential Breakthrough in HCC-Targeted Therapy
por: Wu, Yafei, et al.
Publicado: (2020)

5-Fluorouracil: Mechanisms of Resistance and Reversal Strategies
por: Zhang, Ning, et al.
Publicado: (2008)

Editorial: Mechanisms of resistance to the targeted therapy and immunotherapy in cutaneous melanoma
por: Premi, Sanjay, et al.
Publicado: (2022)

Differentiation therapy: sesamin as an effective agent in targeting cancer stem-like side population cells of human gallbladder carcinoma
por: Kong, Xiang, et al.
Publicado: (2014)

Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells
por: Silva, Valdenizia R., et al.
Publicado: (2021)

Novel anti-androgen receptor signaling agents: Understanding the mechanisms of resistance
por: Karanika, Styliani, et al.
Publicado: (2014)

DNA direct reversal repair and alkylating agent drug resistance
por: Gutierrez, Roberto, et al.
Publicado: (2021)

Targeting CRABP-II overcomes pancreatic cancer drug resistance by reversing lipid raft cholesterol accumulation and AKT survival signaling
por: Yu, Shuiliang, et al.
Publicado: (2022)

Targeted Therapy in Melanoma and Mechanisms of Resistance
por: Czarnecka, Anna M., et al.
Publicado: (2020)

Saikosaponin D reverses epinephrine- and norepinephrine-induced gemcitabine resistance in intrahepatic cholangiocarcinoma by downregulating ADRB2/glycolysis signaling: Saikosaponin D reverses gemcitabine resistance
por: He, Hui, et al.
Publicado: (2023)

Construction of Hierarchical-Targeting pH-Sensitive Liposomes to Reverse Chemotherapeutic Resistance of Cancer Stem-like Cells
por: Ba, Shuang, et al.
Publicado: (2021)

Signal-Targeted Therapies and Resistance Mechanisms in Pancreatic Cancer: Future Developments Reside in Proteomics
por: Cintas, Célia, et al.
Publicado: (2018)

Discovering the Mechanisms of Oleodaphnone as a Potential HIV Latency-Reversing Agent by Transcriptome Profiling
por: Li, Shifei, et al.
Publicado: (2023)

Glioblastoma stem cells and Wnt signaling pathway: molecular mechanisms and therapeutic targets
por: Guan, Ruoyu, et al.
Publicado: (2020)

Targeting Cancer Cell Ferroptosis to Reverse Immune Checkpoint Inhibitor Therapy Resistance
por: Deng, Jingjing, et al.
Publicado: (2022)

Semi-synthetic ocotillol analogues as selective ABCB1-mediated drug resistance reversal agents
por: Zhang, Yun-Kai, et al.
Publicado: (2015)

Nanomaterials in Targeting Cancer Stem Cells for Cancer Therapy
por: Qin, Weiwei, et al.
Publicado: (2017)

Candida Infections, Causes, Targets, and Resistance Mechanisms: Traditional and Alternative Antifungal Agents
por: Spampinato, Claudia, et al.
Publicado: (2013)

Antioxidant and anti-inflammatory agents in chronic liver diseases: Molecular mechanisms and therapy
por: Zhang, Chun-Ye, et al.
Publicado: (2023)

The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: Implications in targeted cancer therapies
por: Yang, Ke, et al.
Publicado: (2015)

Lung Cancer Stem Cell Markers as Therapeutic Targets: An Update on Signaling Pathways and Therapies
por: Zheng, Yue, et al.
Publicado: (2022)

Drug resistance mechanism and reversal strategy in lung cancer immunotherapy
por: Xu, Yishi, et al.
Publicado: (2023)

Early Combined SHP2 Targeting Reverses the Therapeutic Resistance of Vemurafenib in Thyroid Cancer
por: Ma, Weike, et al.
Publicado: (2023)

Current status and future prospects of stem cell therapy in Alzheimer’s disease
por: Zhang, Fu-Qiang, et al.
Publicado: (2019)

Emerging Significance of Ginsenosides as Potentially Reversal Agents of Chemoresistance in Cancer Therapy
por: Xu, Jin-Feng, et al.
Publicado: (2021)

Melatonin synergizes BRAF-targeting agent vemurafenib in melanoma treatment by inhibiting iNOS/hTERT signaling and cancer-stem cell traits
por: Hao, Jiaojiao, et al.
Publicado: (2019)

Reversal of IKZF1-induced glucocorticoid resistance by dual targeting of AKT and ERK signaling pathways
por: Butler, Miriam, et al.
Publicado: (2022)

Targeting Ceramide Synthesis to Reverse Insulin Resistance
por: Schmitz-Peiffer, Carsten
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_n2g9ee0nh6n5o6tv3qskv42lfl