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Tenascin-W: Discovery, Evolution, and Future Prospects
Of the four tenascins found in bony fish and tetrapods, tenascin-W is the least understood. It was first discovered in the zebrafish and later in mouse, where it was mistakenly named tenascin-N. Tenascin-W is expressed primarily in developing and mature bone, in a subset of stem cell niches, and in...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884750/ https://www.ncbi.nlm.nih.gov/pubmed/33603752 http://dx.doi.org/10.3389/fimmu.2020.623305 |
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author | Degen, Martin Scherberich, Arnaud Tucker, Richard P. |
author_facet | Degen, Martin Scherberich, Arnaud Tucker, Richard P. |
author_sort | Degen, Martin |
collection | PubMed |
description | Of the four tenascins found in bony fish and tetrapods, tenascin-W is the least understood. It was first discovered in the zebrafish and later in mouse, where it was mistakenly named tenascin-N. Tenascin-W is expressed primarily in developing and mature bone, in a subset of stem cell niches, and in the stroma of many solid tumors. Phylogenetic studies show that it is the most recent tenascin to evolve, appearing first in bony fishes. Its expression in bone and the timing of its evolutionary appearance should direct future studies to its role in bone formation, in stem cell niches, and in the treatment and detection of cancer. |
format | Online Article Text |
id | pubmed-7884750 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78847502021-02-17 Tenascin-W: Discovery, Evolution, and Future Prospects Degen, Martin Scherberich, Arnaud Tucker, Richard P. Front Immunol Immunology Of the four tenascins found in bony fish and tetrapods, tenascin-W is the least understood. It was first discovered in the zebrafish and later in mouse, where it was mistakenly named tenascin-N. Tenascin-W is expressed primarily in developing and mature bone, in a subset of stem cell niches, and in the stroma of many solid tumors. Phylogenetic studies show that it is the most recent tenascin to evolve, appearing first in bony fishes. Its expression in bone and the timing of its evolutionary appearance should direct future studies to its role in bone formation, in stem cell niches, and in the treatment and detection of cancer. Frontiers Media S.A. 2021-02-02 /pmc/articles/PMC7884750/ /pubmed/33603752 http://dx.doi.org/10.3389/fimmu.2020.623305 Text en Copyright © 2021 Degen, Scherberich and Tucker http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Degen, Martin Scherberich, Arnaud Tucker, Richard P. Tenascin-W: Discovery, Evolution, and Future Prospects |
title | Tenascin-W: Discovery, Evolution, and Future Prospects |
title_full | Tenascin-W: Discovery, Evolution, and Future Prospects |
title_fullStr | Tenascin-W: Discovery, Evolution, and Future Prospects |
title_full_unstemmed | Tenascin-W: Discovery, Evolution, and Future Prospects |
title_short | Tenascin-W: Discovery, Evolution, and Future Prospects |
title_sort | tenascin-w: discovery, evolution, and future prospects |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884750/ https://www.ncbi.nlm.nih.gov/pubmed/33603752 http://dx.doi.org/10.3389/fimmu.2020.623305 |
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