Circular RNA circ_103820 suppresses lung cancer tumorigenesis by sponging miR-200b-3p to release LATS2 and SOCS6

A growing number of circular RNAs (circRNAs) have been identified and verified in several cancers. However, highly efficient therapeutic methods based on circRNAs in lung cancer remain largely unexplored. In the present study, we identified a novel circular RNA, hsa_circ_103820, based on Gene Expres...

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Autores principales: Chi, Yongbin, Zheng, Wenlong, Bao, Guangyu, Wu, Lifeng, He, Xiaoxue, Gan, Ruyi, Shen, Yan, Yin, Xudong, Jin, Mingming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884777/
https://www.ncbi.nlm.nih.gov/pubmed/33589592
http://dx.doi.org/10.1038/s41419-021-03472-7
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author Chi, Yongbin
Zheng, Wenlong
Bao, Guangyu
Wu, Lifeng
He, Xiaoxue
Gan, Ruyi
Shen, Yan
Yin, Xudong
Jin, Mingming
author_facet Chi, Yongbin
Zheng, Wenlong
Bao, Guangyu
Wu, Lifeng
He, Xiaoxue
Gan, Ruyi
Shen, Yan
Yin, Xudong
Jin, Mingming
author_sort Chi, Yongbin
collection PubMed
description A growing number of circular RNAs (circRNAs) have been identified and verified in several cancers. However, highly efficient therapeutic methods based on circRNAs in lung cancer remain largely unexplored. In the present study, we identified a novel circular RNA, hsa_circ_103820, based on Gene Expression Omnibus (GEO) data. Functionally, overexpression of hsa_circ_103820 showed significant inhibitory effects on the proliferation, migration and invasion of lung cancer cells, and knockdown of hsa_circ_103820 played promoting roles. Regarding the mechanism, we revealed that miR-200b-3p was a direct target of hsa_circ_103820 and that LATS2 and SOCS6 were the downstream target genes of miR-200b-3p. Therefore, we identified a novel potential tumor suppressive function of hsa_circ_103820 in lung cancer.
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spelling pubmed-78847772021-02-25 Circular RNA circ_103820 suppresses lung cancer tumorigenesis by sponging miR-200b-3p to release LATS2 and SOCS6 Chi, Yongbin Zheng, Wenlong Bao, Guangyu Wu, Lifeng He, Xiaoxue Gan, Ruyi Shen, Yan Yin, Xudong Jin, Mingming Cell Death Dis Article A growing number of circular RNAs (circRNAs) have been identified and verified in several cancers. However, highly efficient therapeutic methods based on circRNAs in lung cancer remain largely unexplored. In the present study, we identified a novel circular RNA, hsa_circ_103820, based on Gene Expression Omnibus (GEO) data. Functionally, overexpression of hsa_circ_103820 showed significant inhibitory effects on the proliferation, migration and invasion of lung cancer cells, and knockdown of hsa_circ_103820 played promoting roles. Regarding the mechanism, we revealed that miR-200b-3p was a direct target of hsa_circ_103820 and that LATS2 and SOCS6 were the downstream target genes of miR-200b-3p. Therefore, we identified a novel potential tumor suppressive function of hsa_circ_103820 in lung cancer. Nature Publishing Group UK 2021-02-15 /pmc/articles/PMC7884777/ /pubmed/33589592 http://dx.doi.org/10.1038/s41419-021-03472-7 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Chi, Yongbin
Zheng, Wenlong
Bao, Guangyu
Wu, Lifeng
He, Xiaoxue
Gan, Ruyi
Shen, Yan
Yin, Xudong
Jin, Mingming
Circular RNA circ_103820 suppresses lung cancer tumorigenesis by sponging miR-200b-3p to release LATS2 and SOCS6
title Circular RNA circ_103820 suppresses lung cancer tumorigenesis by sponging miR-200b-3p to release LATS2 and SOCS6
title_full Circular RNA circ_103820 suppresses lung cancer tumorigenesis by sponging miR-200b-3p to release LATS2 and SOCS6
title_fullStr Circular RNA circ_103820 suppresses lung cancer tumorigenesis by sponging miR-200b-3p to release LATS2 and SOCS6
title_full_unstemmed Circular RNA circ_103820 suppresses lung cancer tumorigenesis by sponging miR-200b-3p to release LATS2 and SOCS6
title_short Circular RNA circ_103820 suppresses lung cancer tumorigenesis by sponging miR-200b-3p to release LATS2 and SOCS6
title_sort circular rna circ_103820 suppresses lung cancer tumorigenesis by sponging mir-200b-3p to release lats2 and socs6
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884777/
https://www.ncbi.nlm.nih.gov/pubmed/33589592
http://dx.doi.org/10.1038/s41419-021-03472-7
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