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Modulating proteasome inhibitor tolerance in multiple myeloma: an alternative strategy to reverse inevitable resistance

BACKGROUND: Resistance to proteasome inhibitors (PIs) is a major obstacle to the successful treatment of multiple myeloma (MM). Many mechanisms have been proposed for PI resistance; however, our mechanistic understanding of how PI resistance is inevitably acquired and reversed remains incomplete. ME...

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Detalles Bibliográficos
Autores principales: Ge, Maolin, Qiao, Zhi, Kong, Yan, Liang, Hongyu, Sun, Yan, Lu, Hui, Xu, Zhenshu, Liu, Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884794/
https://www.ncbi.nlm.nih.gov/pubmed/33250513
http://dx.doi.org/10.1038/s41416-020-01191-y