Cargando…

Co-Therapy of Pegylated G-CSF and Ghrelin for Enhancing Survival After Exposure to Lethal Radiation

Exposure to ionizing radiation (radiation injury, RI) in nuclear-related episode is evident to be life-threatening. RI occurs at levels of organs, tissues, cytosols, or nucleus. Their mechanisms are still not fully understood. FDA approves pegylated granulocyte colony-stimulating factor (Neulasta™,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kiang, Juliann G., Zhai, Min, Lin, Bin, Smith, Joan T., Anderson, Marsha N., Jiang, Suping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884820/ https://www.ncbi.nlm.nih.gov/pubmed/33603673 http://dx.doi.org/10.3389/fphar.2021.628018

Ejemplares similares

Ghrelin therapy mitigates bone marrow injury and splenocytopenia by sustaining circulating G-CSF and KC increases after irradiation combined with wound
por: Kiang, Juliann G., et al.
Publicado: (2018)

A novel therapy, using Ghrelin with pegylated G-CSF, inhibits brain hemorrhage from ionizing radiation or combined radiation injury
por: Kiang, JG, et al.
Publicado: (2019)

Ghrelin, a novel therapy, corrects cytokine and NF-κB-AKT-MAPK network and mitigates intestinal injury induced by combined radiation and skin-wound trauma
por: Kiang, Juliann G., et al.
Publicado: (2020)

Pegylated G-CSF Inhibits Blood Cell Depletion, Increases Platelets, Blocks Splenomegaly, and Improves Survival after Whole-Body Ionizing Irradiation but Not after Irradiation Combined with Burn
por: Kiang, Juliann G., et al.
Publicado: (2014)

Ghrelin Therapy Improves Survival after Whole-Body Ionizing Irradiation or Combined with Burn or Wound: Amelioration of Leukocytopenia, Thrombocytopenia, Splenomegaly, and Bone Marrow Injury
por: Kiang, Juliann G., et al.
Publicado: (2014)

Hemorrhage Exacerbates Radiation Effects on Survival, Leukocytopenia, Thrombopenia, Erythropenia, Bone Marrow Cell Depletion and Hematopoiesis, and Inflammation-Associated microRNAs Expression in Kidney
por: Kiang, Juliann G., et al.
Publicado: (2015)

Ghrelin Therapy Decreases Incidents of Intracranial Hemorrhage in Mice after Whole-Body Ionizing Irradiation Combined with Burn Trauma
por: Gorbunov, Nikolai V., et al.
Publicado: (2017)

Is PEGylated G-CSF superior to G-CSF in patients with breast cancer receiving chemotherapy? A systematic review and meta-analysis
por: Li, Xiang, et al.
Publicado: (2020)

Pegylated G-CSF Combined with mFOLFIRINOX for Advanced Pancreatic Cancer Patients
por: Chen, Peng, et al.
Publicado: (2019)

Effects of pegylated G-CSF on immune cell number and function in patients with gynecological malignancies
por: Bonanno, Giuseppina, et al.
Publicado: (2010)

Improving the Therapeutic Potential of G-CSF through Compact Circular PEGylation Based on Orthogonal Conjugations
por: Grigoletto, Antonella, et al.
Publicado: (2023)

Thrombopoietin Receptor Agonist Mitigates Hematopoietic Radiation Syndrome and Improves Survival after Whole-Body Ionizing Irradiation Followed by Wound Trauma
por: Kiang, Juliann G., et al.
Publicado: (2017)

From Synthesis to Characterization of Site-Selective PEGylated Proteins
por: Belén, Lisandra Herrera, et al.
Publicado: (2019)

The Influence of Feeding Pattern on Changes in Plasma Ghrelin in the Holstein Cow
por: MIURA, Hiroshi, et al.
Publicado: (2014)

Rikkunshito, a ghrelin potentiator, ameliorates anorexia–cachexia syndrome
por: Fujitsuka, Naoki, et al.
Publicado: (2014)

Synthesis, characterization and in vitro release performance of the pegylated valnemulin prodrug
por: DONG, Xinrui, et al.
Publicado: (2017)

Synthesis and Characterization of Poly (β-amino Ester) and Applied PEGylated and Non-PEGylated Poly (β-amino ester)/Plasmid DNA Nanoparticles for Efficient Gene Delivery
por: Iqbal, Sajid, et al.
Publicado: (2022)

Radiation: a poly-traumatic hit leading to multi-organ injury
por: Kiang, Juliann G., et al.
Publicado: (2019)

Folate-Targeted PEGylated Magnetoliposomes for Hyperthermia-Mediated Controlled Release of Doxorubicin
por: Cintra, Emílio R., et al.
Publicado: (2022)

Biophysical Characterization of Met-G-CSF: Effects of Different Site-Specific Mono-Pegylations on Protein Stability and Aggregation
por: Natalello, Antonino, et al.
Publicado: (2012)

Exploring the Use of Pegylated Liposomal Doxorubicin (Caelyx(®)) as Pressurized Intraperitoneal Aerosol Chemotherapy
por: Robella, Manuela, et al.
Publicado: (2019)

Involvement of PPARγ in the Anticonvulsant Activity of EP-80317, a Ghrelin Receptor Antagonist
por: Lucchi, Chiara, et al.
Publicado: (2017)

Acylated Ghrelin is Protective Against 6-OHDA-induced Neurotoxicity by Regulating Autophagic Flux
por: He, Xin, et al.
Publicado: (2021)

Targeting GGT1 Eliminates the Tumor-Promoting Effect and Enhanced Immunosuppressive Function of Myeloid-Derived Suppressor Cells Caused by G-CSF
por: Xie, Zhiqi, et al.
Publicado: (2022)

GM-CSF: Orchestrating the Pulmonary Response to Infection
por: McCormick, Thomas S., et al.
Publicado: (2022)

Rationale and Application of PEGylated Lipid-Based System for Advanced Target Delivery of siRNA
por: Ge, Xuemei, et al.
Publicado: (2021)

Deteriorative Effects of Radiation Injury Combined with Skin Wounding in a Mouse Model
por: Wang, Li, et al.
Publicado: (2022)

Skin Wound following Irradiation Aggravates Radiation-Induced Brain Injury in a Mouse Model
por: Xiao, Mang, et al.
Publicado: (2023)

In Vivo Toxicity Evaluation of PEGylated CuInS(2)/ZnS Quantum Dots in BALB/c Mice
por: Zou, Wenyi, et al.
Publicado: (2019)

Biomarkers of PEGylated Liposomal Doxorubicin-Induced Hypersensitivity Reaction in Breast Cancer Patients Based on Metabolomics
por: Zhuang, Wei, et al.
Publicado: (2022)

The Alleviation of LPS-Induced Murine Acute Lung Injury by GSH-Mediated PEGylated Artesunate Prodrugs
por: Hao, Dan-Li, et al.
Publicado: (2022)

Ghrelin Inhibits Intestinal Epithelial Cell Apoptosis Through the Unfolded Protein Response Pathway in Ulcerative Colitis
por: Zhang, Lin, et al.
Publicado: (2021)

Bone Marrow Mesenchymal Stem Cells Increase Survival after Ionizing Irradiation Combined with Wound Trauma: Characterization and Therapy
por: Kiang, Juliann G, et al.
Publicado: (2014)

Ghrelin Attenuates Neuroinflammation and Demyelination in Experimental Autoimmune Encephalomyelitis Involving NLRP3 Inflammasome Signaling Pathway and Pyroptosis
por: Liu, Fei, et al.
Publicado: (2019)

Ghrelin receptor antagonist JMV2959 blunts cocaine and oxycodone drug-seeking, but not self-administration, in male rats
por: Merritt, Christina R., et al.
Publicado: (2023)

From the stomach to locus coeruleus: new neural substrate for ghrelin’s effects on ingestive, motivated and anxiety-like behaviors
por: Maric, Ivana, et al.
Publicado: (2023)

High-resolution melting analysis of the common c.1905+1G>A mutation causing dihydropyrimidine dehydrogenase deficiency and lethal 5-fluorouracil toxicity
por: Borràs, Emma, et al.
Publicado: (2013)

Hemorrhage enhances cytokine, complement component 3, and caspase-3, and regulates microRNAs associated with intestinal damage after whole-body gamma-irradiation in combined injury
por: Kiang, Juliann G., et al.
Publicado: (2017)

Establishment of the first international standard for PEGylated granulocyte colony stimulating factor (PEG-G-CSF): Report of an international collaborative study
por: Wadhwa, Meenu, et al.
Publicado: (2015)

Cost-Effectiveness Analysis of PEG-rhG-CSF as Primary Prophylaxis to Chemotherapy-Induced Neutropenia in Women With Breast Cancer in China: Results Based on Real-World Data
por: Zhao, Jie, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_5r1omkcf2bd3muttge3db5b5ii