Cargando…

Computational Prediction of Hot Spots and Binding Site of Inhibitor NSC23766 on Rac1 Binding With Tiam1

Rac1 is a small signaling protein, which belongs to the Rho subfamily of Ras superfamily. It is activated by binding GTP and inactivated by exchanging GDP for GTP. The ability of nucleotide exchange depends on guanine nucleotide exchange factors (GEFs) family proteins. T-lymphoma invasion and metast...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zheng, Chunwen, Wu, Xiaodong, Zeng, Ruijie, Lin, Lirui, Xu, Liyan, Li, Enmin, Dong, Geng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884829/ https://www.ncbi.nlm.nih.gov/pubmed/33604328 http://dx.doi.org/10.3389/fchem.2020.625437

Ejemplares similares

The Rac1 Inhibitor NSC23766 Exerts Anti-Influenza Virus Properties by Affecting the Viral Polymerase Complex Activity
por: Dierkes, Rüdiger, et al.
Publicado: (2014)

Inhibition of Rac1 activity by NSC23766 prevents cartilage endplate degeneration via Wnt/β‐catenin pathway
por: Jiang, Chao, et al.
Publicado: (2020)

Inhibition of Female and Male Human Detrusor Smooth Muscle Contraction by the Rac Inhibitors EHT1864 and NSC23766
por: Li, Bingsheng, et al.
Publicado: (2020)

Inhibition of Rac1 activity by controlled release of NSC23766 from chitosan microspheres effectively ameliorates osteoarthritis development in vivo
por: Zhu, Shouan, et al.
Publicado: (2015)

The phosphomimetic mutation of syndecan-4 binds and inhibits Tiam1 modulating Rac1 activity in PDZ interaction–dependent manner
por: Keller-Pinter, Aniko, et al.
Publicado: (2017)

The Rac activator Tiam1 controls tight junction biogenesis in keratinocytes through binding to and activation of the Par polarity complex
por: Mertens, Alexander E.E., et al.
Publicado: (2005)

Probing binding hot spots at protein–RNA recognition sites
por: Barik, Amita, et al.
Publicado: (2016)

The sirtuins promote Dishevelled-1 scaffolding of TIAM1, Rac activation, and cell migration
por: Saxena, Madhurima, et al.
Publicado: (2013)

Tiam1/Rac1 complex controls Il17a transcription and autoimmunity
por: Kurdi, Ahmed T., et al.
Publicado: (2016)

The Light Chain 1 Subunit of the Microtubule-Associated Protein 1B (MAP1B) Is Responsible for Tiam1 Binding and Rac1 Activation in Neuronal Cells
por: Henríquez, Daniel R., et al.
Publicado: (2012)

The RAC1 activator Tiam1 regulates centriole duplication through controlling PLK4 levels
por: Porter, Andrew P., et al.
Publicado: (2021)

The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module
por: Terawaki, Shin-ichi, et al.
Publicado: (2010)

Ankyrin–Tiam1 Interaction Promotes Rac1 Signaling and Metastatic Breast Tumor Cell Invasion and Migration
por: Bourguignon, Lilly Y.W., et al.
Publicado: (2000)

Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation
por: Whalley, Helen J., et al.
Publicado: (2015)

STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap
por: Woroniuk, Anna, et al.
Publicado: (2018)

Dendrite regeneration in C. elegans is controlled by the RAC GTPase CED-10 and the RhoGEF TIAM-1
por: Brar, Harjot Kaur, et al.
Publicado: (2022)

Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration
por: Wang, Shujie, et al.
Publicado: (2012)

HUWE1 Ubiquitylates and Degrades the RAC Activator TIAM1 Promoting Cell-Cell Adhesion Disassembly, Migration, and Invasion
por: Vaughan, Lynsey, et al.
Publicado: (2014)

Tiam1 increases turnover
por: Short, Ben
Publicado: (2012)

Tiam1-Rac Signaling Counteracts Eg5 during Bipolar Spindle Assembly to Facilitate Chromosome Congression
por: Woodcock, Simon A., et al.
Publicado: (2010)

The Rac activator Tiam1 is required for polarized protrusional outgrowth of primary astrocytes by affecting the organization of the microtubule network
por: Ellenbroek, Saskia I. J., et al.
Publicado: (2012)

A missense variant at the RAC1-PAK1 binding site of RAC1 inactivates downstream signaling in VACTERL association
por: Seyama, Rie, et al.
Publicado: (2023)

Investigation of Hot Spot Region in XIAP Inhibitor Binding Site by Fragment Molecular Orbital Method
por: Lim, Hocheol, et al.
Publicado: (2019)

Rac1 GTPase and the Rac1 exchange factor Tiam1 associate with Wnt-responsive promoters to enhance beta-catenin/TCF-dependent transcription in colorectal cancer cells
por: Buongiorno, Pinella, et al.
Publicado: (2008)

Computational analysis of hot spots and binding mechanism in the PD-1/PD-L1 interaction
por: Huang, Dading, et al.
Publicado: (2019)

The Guanine Nucleotide Exchange Factor Tiam1 Affects Neuronal Morphology; Opposing Roles for the Small GTPases Rac and Rho
por: van Leeuwen, Frank N., et al.
Publicado: (1997)

Recognition and binding of mismatch repair proteins at an oncogenic hot spot
por: Edelbrock, Michael, et al.
Publicado: (2005)

The Rac activator Tiam1 is required for α3β1-mediated laminin-5 deposition, cell spreading, and cell migration
por: Hamelers, Irene H.L., et al.
Publicado: (2005)

Co-targeting of Tiam1/Rac1 and Notch ameliorates chemoresistance against doxorubicin in a biomimetic 3D lymphoma model
por: Ikram, Muhammad, et al.
Publicado: (2017)

Recruitment of Tiam1 to Semaphorin 4D Activates Rac and Enhances Proliferation, Invasion, and Metastasis in Oral Squamous Cell Carcinoma
por: Zhou, Hua, et al.
Publicado: (2016)

Prediction of binding hot spot residues by using structural and evolutionary parameters
por: Higa, Roberto Hiroshi, et al.
Publicado: (2009)

Co-Occurring Atomic Contacts for the Characterization of Protein Binding Hot Spots
por: Liu, Qian, et al.
Publicado: (2015)

A conserved TLR5 binding and activation hot spot on flagellin
por: Song, Wan Seok, et al.
Publicado: (2017)

A novel caveolin-1/p85α/Rab5/Tiam1/Rac1 signaling axis in tumor cell migration and invasion
por: Díaz, Jorge, et al.
Publicado: (2014)

Rac1 GTPase activates the WAVE regulatory complex through two distinct binding sites
por: Chen, Baoyu, et al.
Publicado: (2017)

5-Lipoxygenase and cysteinyl leukotriene receptor 1 regulate epidermal growth factor-induced cell migration through Tiam1 upregulation and Rac1 activation
por: Magi, Shigeyuki, et al.
Publicado: (2014)

Tiam–Rac signaling mediates trans-endocytosis of ephrin receptor EphB2 and is important for cell repulsion
por: Gaitanos, Thomas N., et al.
Publicado: (2016)

Variable ligand- and receptor-binding hot spots in key strains of influenza neuraminidase
por: Votapka, Lane, et al.
Publicado: (2012)

Integrating water exclusion theory into βcontacts to predict binding free energy changes and binding hot spots
por: Liu, Qian, et al.
Publicado: (2014)

Hot Spots in a Network of Functional Sites
por: Ozbek, Pemra, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_bavqq34v8k1c3dnodu4cprso5s