Cargando…
Multiple organ dysfunction syndrome: Contemporary insights on the clinicopathological spectrum
Multiorgan dysfunction syndrome (MODS) remains a major complication and challenge to treat patients with critical illness in different intensive care unit settings. The exact mechanism and pathophysiology of MODS is complex and remains unexplored. We reviewed the literature from January 2011 to Augu...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
HBKU Press
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884906/ https://www.ncbi.nlm.nih.gov/pubmed/33628712 http://dx.doi.org/10.5339/qmj.2020.22 |
_version_ | 1783651512202821632 |
---|---|
author | Asim, Mohammad Amin, Farhana El-Menyar, Ayman |
author_facet | Asim, Mohammad Amin, Farhana El-Menyar, Ayman |
author_sort | Asim, Mohammad |
collection | PubMed |
description | Multiorgan dysfunction syndrome (MODS) remains a major complication and challenge to treat patients with critical illness in different intensive care unit settings. The exact mechanism and pathophysiology of MODS is complex and remains unexplored. We reviewed the literature from January 2011 to August 2019 to analyze the underlying mechanisms, prognostic factors, MODS scoring systems, organ systems dysfunctions, and the management of MODS. We used the search engines PubMed, MEDLINE, Scopus, and Google Scholar with the keywords “multiple organ dysfunction syndrome,” “intensive care units,” “multiorgan failure,” “MODS scoring system,” and “MODS management.” The initial search yielded 3550 abstracts, of which 91 articles were relevant to the scope of the present article. A better understanding of a disease course will help differentiate the signs of an intense inflammatory response from the early onset of sepsis and minimize the inappropriate use of medications. This, in turn, will promote organtargeted therapy and prevent occurrence and progression of MODS. |
format | Online Article Text |
id | pubmed-7884906 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | HBKU Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-78849062021-02-23 Multiple organ dysfunction syndrome: Contemporary insights on the clinicopathological spectrum Asim, Mohammad Amin, Farhana El-Menyar, Ayman Qatar Med J Research Article Multiorgan dysfunction syndrome (MODS) remains a major complication and challenge to treat patients with critical illness in different intensive care unit settings. The exact mechanism and pathophysiology of MODS is complex and remains unexplored. We reviewed the literature from January 2011 to August 2019 to analyze the underlying mechanisms, prognostic factors, MODS scoring systems, organ systems dysfunctions, and the management of MODS. We used the search engines PubMed, MEDLINE, Scopus, and Google Scholar with the keywords “multiple organ dysfunction syndrome,” “intensive care units,” “multiorgan failure,” “MODS scoring system,” and “MODS management.” The initial search yielded 3550 abstracts, of which 91 articles were relevant to the scope of the present article. A better understanding of a disease course will help differentiate the signs of an intense inflammatory response from the early onset of sepsis and minimize the inappropriate use of medications. This, in turn, will promote organtargeted therapy and prevent occurrence and progression of MODS. HBKU Press 2020-09-22 /pmc/articles/PMC7884906/ /pubmed/33628712 http://dx.doi.org/10.5339/qmj.2020.22 Text en © 2020 Asim, Amin, El-Menyar, licensee HBKU Press. This is an open access article distributed under the terms of the Creative Commons Attribution license CC BY 4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Asim, Mohammad Amin, Farhana El-Menyar, Ayman Multiple organ dysfunction syndrome: Contemporary insights on the clinicopathological spectrum |
title | Multiple organ dysfunction syndrome: Contemporary insights on the clinicopathological spectrum |
title_full | Multiple organ dysfunction syndrome: Contemporary insights on the clinicopathological spectrum |
title_fullStr | Multiple organ dysfunction syndrome: Contemporary insights on the clinicopathological spectrum |
title_full_unstemmed | Multiple organ dysfunction syndrome: Contemporary insights on the clinicopathological spectrum |
title_short | Multiple organ dysfunction syndrome: Contemporary insights on the clinicopathological spectrum |
title_sort | multiple organ dysfunction syndrome: contemporary insights on the clinicopathological spectrum |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884906/ https://www.ncbi.nlm.nih.gov/pubmed/33628712 http://dx.doi.org/10.5339/qmj.2020.22 |
work_keys_str_mv | AT asimmohammad multipleorgandysfunctionsyndromecontemporaryinsightsontheclinicopathologicalspectrum AT aminfarhana multipleorgandysfunctionsyndromecontemporaryinsightsontheclinicopathologicalspectrum AT elmenyarayman multipleorgandysfunctionsyndromecontemporaryinsightsontheclinicopathologicalspectrum |