Cargando…

Multiple organ dysfunction syndrome: Contemporary insights on the clinicopathological spectrum

Multiorgan dysfunction syndrome (MODS) remains a major complication and challenge to treat patients with critical illness in different intensive care unit settings. The exact mechanism and pathophysiology of MODS is complex and remains unexplored. We reviewed the literature from January 2011 to Augu...

Descripción completa

Detalles Bibliográficos
Autores principales: Asim, Mohammad, Amin, Farhana, El-Menyar, Ayman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: HBKU Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884906/
https://www.ncbi.nlm.nih.gov/pubmed/33628712
http://dx.doi.org/10.5339/qmj.2020.22
_version_ 1783651512202821632
author Asim, Mohammad
Amin, Farhana
El-Menyar, Ayman
author_facet Asim, Mohammad
Amin, Farhana
El-Menyar, Ayman
author_sort Asim, Mohammad
collection PubMed
description Multiorgan dysfunction syndrome (MODS) remains a major complication and challenge to treat patients with critical illness in different intensive care unit settings. The exact mechanism and pathophysiology of MODS is complex and remains unexplored. We reviewed the literature from January 2011 to August 2019 to analyze the underlying mechanisms, prognostic factors, MODS scoring systems, organ systems dysfunctions, and the management of MODS. We used the search engines PubMed, MEDLINE, Scopus, and Google Scholar with the keywords “multiple organ dysfunction syndrome,” “intensive care units,” “multiorgan failure,” “MODS scoring system,” and “MODS management.” The initial search yielded 3550 abstracts, of which 91 articles were relevant to the scope of the present article. A better understanding of a disease course will help differentiate the signs of an intense inflammatory response from the early onset of sepsis and minimize the inappropriate use of medications. This, in turn, will promote organtargeted therapy and prevent occurrence and progression of MODS.
format Online
Article
Text
id pubmed-7884906
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher HBKU Press
record_format MEDLINE/PubMed
spelling pubmed-78849062021-02-23 Multiple organ dysfunction syndrome: Contemporary insights on the clinicopathological spectrum Asim, Mohammad Amin, Farhana El-Menyar, Ayman Qatar Med J Research Article Multiorgan dysfunction syndrome (MODS) remains a major complication and challenge to treat patients with critical illness in different intensive care unit settings. The exact mechanism and pathophysiology of MODS is complex and remains unexplored. We reviewed the literature from January 2011 to August 2019 to analyze the underlying mechanisms, prognostic factors, MODS scoring systems, organ systems dysfunctions, and the management of MODS. We used the search engines PubMed, MEDLINE, Scopus, and Google Scholar with the keywords “multiple organ dysfunction syndrome,” “intensive care units,” “multiorgan failure,” “MODS scoring system,” and “MODS management.” The initial search yielded 3550 abstracts, of which 91 articles were relevant to the scope of the present article. A better understanding of a disease course will help differentiate the signs of an intense inflammatory response from the early onset of sepsis and minimize the inappropriate use of medications. This, in turn, will promote organtargeted therapy and prevent occurrence and progression of MODS. HBKU Press 2020-09-22 /pmc/articles/PMC7884906/ /pubmed/33628712 http://dx.doi.org/10.5339/qmj.2020.22 Text en © 2020 Asim, Amin, El-Menyar, licensee HBKU Press. This is an open access article distributed under the terms of the Creative Commons Attribution license CC BY 4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Asim, Mohammad
Amin, Farhana
El-Menyar, Ayman
Multiple organ dysfunction syndrome: Contemporary insights on the clinicopathological spectrum
title Multiple organ dysfunction syndrome: Contemporary insights on the clinicopathological spectrum
title_full Multiple organ dysfunction syndrome: Contemporary insights on the clinicopathological spectrum
title_fullStr Multiple organ dysfunction syndrome: Contemporary insights on the clinicopathological spectrum
title_full_unstemmed Multiple organ dysfunction syndrome: Contemporary insights on the clinicopathological spectrum
title_short Multiple organ dysfunction syndrome: Contemporary insights on the clinicopathological spectrum
title_sort multiple organ dysfunction syndrome: contemporary insights on the clinicopathological spectrum
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884906/
https://www.ncbi.nlm.nih.gov/pubmed/33628712
http://dx.doi.org/10.5339/qmj.2020.22
work_keys_str_mv AT asimmohammad multipleorgandysfunctionsyndromecontemporaryinsightsontheclinicopathologicalspectrum
AT aminfarhana multipleorgandysfunctionsyndromecontemporaryinsightsontheclinicopathologicalspectrum
AT elmenyarayman multipleorgandysfunctionsyndromecontemporaryinsightsontheclinicopathologicalspectrum