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Invasive pulmonary aspergillosis in COVID-19 critically ill patients: Results of a French monocentric cohort

INTRODUCTION: Coronavirus disease 2019 or COVID-19 is a new infectious disease responsible for potentially severe respiratory impairment associated with initial immunosuppression. Similarly to influenza, several authors have described a higher risk of fungal infection after COVID-19, in particular f...

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Autores principales: Versyck, Maaike, Zarrougui, Wafa, Lambiotte, Fabien, Elbeki, Nabil, Saint-Leger, Piehr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884920/
https://www.ncbi.nlm.nih.gov/pubmed/33621792
http://dx.doi.org/10.1016/j.mycmed.2021.101122
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author Versyck, Maaike
Zarrougui, Wafa
Lambiotte, Fabien
Elbeki, Nabil
Saint-Leger, Piehr
author_facet Versyck, Maaike
Zarrougui, Wafa
Lambiotte, Fabien
Elbeki, Nabil
Saint-Leger, Piehr
author_sort Versyck, Maaike
collection PubMed
description INTRODUCTION: Coronavirus disease 2019 or COVID-19 is a new infectious disease responsible for potentially severe respiratory impairment associated with initial immunosuppression. Similarly to influenza, several authors have described a higher risk of fungal infection after COVID-19, in particular for invasive pulmonary aspergillosis. The main objective here is to define the prevalence of invasive pulmonary aspergillosis (IPA) in a cohort of COVID-19 patients with moderate to severe acute respiratory disease syndrome (ARDS). MATERIAL AND METHODS: We conducted a large monocentric retrospective study investigating all the ventilated COVID-19 patients with ARDS hospitalized at Valenciennes’ general hospital, France, between March 15, 2020 and April 30, 2020. In the center a systematic IPA screening strategy was carried out for all ARDS patients, with weekly tests of serum galactomannan and beta-D-glucan. Bronchoalveolar lavage with culture and chest CT scan were performed when the serum assays were positives. RESULTS: A total of 54 patients were studied. Their median age was 65 years, and 37 of the patients (71%) were male. Two patients had chronic immunosuppression and among all the patients, only 2 non-immunocompromised presented a putative IPA during their stay. CONCLUSION: The prevalence of IPA in this cohort of COVID-19 patients (3.7%) is not higher than what is described in the other ARDS populations in the literature. These results are however different from the previous publications on COVID-19 patients and must therefore be confirmed by larger and multicentric studies.
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spelling pubmed-78849202021-02-16 Invasive pulmonary aspergillosis in COVID-19 critically ill patients: Results of a French monocentric cohort Versyck, Maaike Zarrougui, Wafa Lambiotte, Fabien Elbeki, Nabil Saint-Leger, Piehr J Mycol Med Research Paper INTRODUCTION: Coronavirus disease 2019 or COVID-19 is a new infectious disease responsible for potentially severe respiratory impairment associated with initial immunosuppression. Similarly to influenza, several authors have described a higher risk of fungal infection after COVID-19, in particular for invasive pulmonary aspergillosis. The main objective here is to define the prevalence of invasive pulmonary aspergillosis (IPA) in a cohort of COVID-19 patients with moderate to severe acute respiratory disease syndrome (ARDS). MATERIAL AND METHODS: We conducted a large monocentric retrospective study investigating all the ventilated COVID-19 patients with ARDS hospitalized at Valenciennes’ general hospital, France, between March 15, 2020 and April 30, 2020. In the center a systematic IPA screening strategy was carried out for all ARDS patients, with weekly tests of serum galactomannan and beta-D-glucan. Bronchoalveolar lavage with culture and chest CT scan were performed when the serum assays were positives. RESULTS: A total of 54 patients were studied. Their median age was 65 years, and 37 of the patients (71%) were male. Two patients had chronic immunosuppression and among all the patients, only 2 non-immunocompromised presented a putative IPA during their stay. CONCLUSION: The prevalence of IPA in this cohort of COVID-19 patients (3.7%) is not higher than what is described in the other ARDS populations in the literature. These results are however different from the previous publications on COVID-19 patients and must therefore be confirmed by larger and multicentric studies. Elsevier Masson SAS. 2021-06 2021-02-16 /pmc/articles/PMC7884920/ /pubmed/33621792 http://dx.doi.org/10.1016/j.mycmed.2021.101122 Text en © 2021 Elsevier Masson SAS. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Research Paper
Versyck, Maaike
Zarrougui, Wafa
Lambiotte, Fabien
Elbeki, Nabil
Saint-Leger, Piehr
Invasive pulmonary aspergillosis in COVID-19 critically ill patients: Results of a French monocentric cohort
title Invasive pulmonary aspergillosis in COVID-19 critically ill patients: Results of a French monocentric cohort
title_full Invasive pulmonary aspergillosis in COVID-19 critically ill patients: Results of a French monocentric cohort
title_fullStr Invasive pulmonary aspergillosis in COVID-19 critically ill patients: Results of a French monocentric cohort
title_full_unstemmed Invasive pulmonary aspergillosis in COVID-19 critically ill patients: Results of a French monocentric cohort
title_short Invasive pulmonary aspergillosis in COVID-19 critically ill patients: Results of a French monocentric cohort
title_sort invasive pulmonary aspergillosis in covid-19 critically ill patients: results of a french monocentric cohort
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884920/
https://www.ncbi.nlm.nih.gov/pubmed/33621792
http://dx.doi.org/10.1016/j.mycmed.2021.101122
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