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Probiotics and MicroRNA: Their Roles in the Host–Microbe Interactions

Probiotics are widely accepted to be beneficial for the maintenance of the gut homeostasis – the dynamic and healthy interactions between host and gut microorganisms. In addition, emerging as a key molecule of inter-domain communication, microRNAs (miRNAs) can also mediate the host–microbe interacti...

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Autores principales: Zhao, Ying, Zeng, Yan, Zeng, Dong, Wang, Hesong, Zhou, Mengjia, Sun, Ning, Xin, Jinge, Khalique, Abdul, Rajput, Danish Sharafat, Pan, Kangcheng, Shu, Gang, Jing, Bo, Ni, Xueqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7885260/
https://www.ncbi.nlm.nih.gov/pubmed/33603718
http://dx.doi.org/10.3389/fmicb.2020.604462
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author Zhao, Ying
Zeng, Yan
Zeng, Dong
Wang, Hesong
Zhou, Mengjia
Sun, Ning
Xin, Jinge
Khalique, Abdul
Rajput, Danish Sharafat
Pan, Kangcheng
Shu, Gang
Jing, Bo
Ni, Xueqin
author_facet Zhao, Ying
Zeng, Yan
Zeng, Dong
Wang, Hesong
Zhou, Mengjia
Sun, Ning
Xin, Jinge
Khalique, Abdul
Rajput, Danish Sharafat
Pan, Kangcheng
Shu, Gang
Jing, Bo
Ni, Xueqin
author_sort Zhao, Ying
collection PubMed
description Probiotics are widely accepted to be beneficial for the maintenance of the gut homeostasis – the dynamic and healthy interactions between host and gut microorganisms. In addition, emerging as a key molecule of inter-domain communication, microRNAs (miRNAs) can also mediate the host–microbe interactions. However, a comprehensive description and summary of the association between miRNAs and probiotics have not been reported yet. In this review, we have discussed the roles of probiotics and miRNAs in host–microbe interactions and proposed the association of probiotics with altered miRNAs in various intestinal diseases and potential molecular mechanisms underlying the action of probiotics. Furthermore, we provided a perspective of probiotics–miRNA–host/gut microbiota axis applied in search of disease management highly associated with the gut microbiome, which will potentially prove to be beneficial for future studies.
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spelling pubmed-78852602021-02-17 Probiotics and MicroRNA: Their Roles in the Host–Microbe Interactions Zhao, Ying Zeng, Yan Zeng, Dong Wang, Hesong Zhou, Mengjia Sun, Ning Xin, Jinge Khalique, Abdul Rajput, Danish Sharafat Pan, Kangcheng Shu, Gang Jing, Bo Ni, Xueqin Front Microbiol Microbiology Probiotics are widely accepted to be beneficial for the maintenance of the gut homeostasis – the dynamic and healthy interactions between host and gut microorganisms. In addition, emerging as a key molecule of inter-domain communication, microRNAs (miRNAs) can also mediate the host–microbe interactions. However, a comprehensive description and summary of the association between miRNAs and probiotics have not been reported yet. In this review, we have discussed the roles of probiotics and miRNAs in host–microbe interactions and proposed the association of probiotics with altered miRNAs in various intestinal diseases and potential molecular mechanisms underlying the action of probiotics. Furthermore, we provided a perspective of probiotics–miRNA–host/gut microbiota axis applied in search of disease management highly associated with the gut microbiome, which will potentially prove to be beneficial for future studies. Frontiers Media S.A. 2021-01-14 /pmc/articles/PMC7885260/ /pubmed/33603718 http://dx.doi.org/10.3389/fmicb.2020.604462 Text en Copyright © 2021 Zhao, Zeng, Zeng, Wang, Zhou, Sun, Xin, Khalique, Rajput, Pan, Shu, Jing and Ni. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Zhao, Ying
Zeng, Yan
Zeng, Dong
Wang, Hesong
Zhou, Mengjia
Sun, Ning
Xin, Jinge
Khalique, Abdul
Rajput, Danish Sharafat
Pan, Kangcheng
Shu, Gang
Jing, Bo
Ni, Xueqin
Probiotics and MicroRNA: Their Roles in the Host–Microbe Interactions
title Probiotics and MicroRNA: Their Roles in the Host–Microbe Interactions
title_full Probiotics and MicroRNA: Their Roles in the Host–Microbe Interactions
title_fullStr Probiotics and MicroRNA: Their Roles in the Host–Microbe Interactions
title_full_unstemmed Probiotics and MicroRNA: Their Roles in the Host–Microbe Interactions
title_short Probiotics and MicroRNA: Their Roles in the Host–Microbe Interactions
title_sort probiotics and microrna: their roles in the host–microbe interactions
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7885260/
https://www.ncbi.nlm.nih.gov/pubmed/33603718
http://dx.doi.org/10.3389/fmicb.2020.604462
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