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Probiotics and MicroRNA: Their Roles in the Host–Microbe Interactions
Probiotics are widely accepted to be beneficial for the maintenance of the gut homeostasis – the dynamic and healthy interactions between host and gut microorganisms. In addition, emerging as a key molecule of inter-domain communication, microRNAs (miRNAs) can also mediate the host–microbe interacti...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7885260/ https://www.ncbi.nlm.nih.gov/pubmed/33603718 http://dx.doi.org/10.3389/fmicb.2020.604462 |
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author | Zhao, Ying Zeng, Yan Zeng, Dong Wang, Hesong Zhou, Mengjia Sun, Ning Xin, Jinge Khalique, Abdul Rajput, Danish Sharafat Pan, Kangcheng Shu, Gang Jing, Bo Ni, Xueqin |
author_facet | Zhao, Ying Zeng, Yan Zeng, Dong Wang, Hesong Zhou, Mengjia Sun, Ning Xin, Jinge Khalique, Abdul Rajput, Danish Sharafat Pan, Kangcheng Shu, Gang Jing, Bo Ni, Xueqin |
author_sort | Zhao, Ying |
collection | PubMed |
description | Probiotics are widely accepted to be beneficial for the maintenance of the gut homeostasis – the dynamic and healthy interactions between host and gut microorganisms. In addition, emerging as a key molecule of inter-domain communication, microRNAs (miRNAs) can also mediate the host–microbe interactions. However, a comprehensive description and summary of the association between miRNAs and probiotics have not been reported yet. In this review, we have discussed the roles of probiotics and miRNAs in host–microbe interactions and proposed the association of probiotics with altered miRNAs in various intestinal diseases and potential molecular mechanisms underlying the action of probiotics. Furthermore, we provided a perspective of probiotics–miRNA–host/gut microbiota axis applied in search of disease management highly associated with the gut microbiome, which will potentially prove to be beneficial for future studies. |
format | Online Article Text |
id | pubmed-7885260 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78852602021-02-17 Probiotics and MicroRNA: Their Roles in the Host–Microbe Interactions Zhao, Ying Zeng, Yan Zeng, Dong Wang, Hesong Zhou, Mengjia Sun, Ning Xin, Jinge Khalique, Abdul Rajput, Danish Sharafat Pan, Kangcheng Shu, Gang Jing, Bo Ni, Xueqin Front Microbiol Microbiology Probiotics are widely accepted to be beneficial for the maintenance of the gut homeostasis – the dynamic and healthy interactions between host and gut microorganisms. In addition, emerging as a key molecule of inter-domain communication, microRNAs (miRNAs) can also mediate the host–microbe interactions. However, a comprehensive description and summary of the association between miRNAs and probiotics have not been reported yet. In this review, we have discussed the roles of probiotics and miRNAs in host–microbe interactions and proposed the association of probiotics with altered miRNAs in various intestinal diseases and potential molecular mechanisms underlying the action of probiotics. Furthermore, we provided a perspective of probiotics–miRNA–host/gut microbiota axis applied in search of disease management highly associated with the gut microbiome, which will potentially prove to be beneficial for future studies. Frontiers Media S.A. 2021-01-14 /pmc/articles/PMC7885260/ /pubmed/33603718 http://dx.doi.org/10.3389/fmicb.2020.604462 Text en Copyright © 2021 Zhao, Zeng, Zeng, Wang, Zhou, Sun, Xin, Khalique, Rajput, Pan, Shu, Jing and Ni. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Zhao, Ying Zeng, Yan Zeng, Dong Wang, Hesong Zhou, Mengjia Sun, Ning Xin, Jinge Khalique, Abdul Rajput, Danish Sharafat Pan, Kangcheng Shu, Gang Jing, Bo Ni, Xueqin Probiotics and MicroRNA: Their Roles in the Host–Microbe Interactions |
title | Probiotics and MicroRNA: Their Roles in the Host–Microbe Interactions |
title_full | Probiotics and MicroRNA: Their Roles in the Host–Microbe Interactions |
title_fullStr | Probiotics and MicroRNA: Their Roles in the Host–Microbe Interactions |
title_full_unstemmed | Probiotics and MicroRNA: Their Roles in the Host–Microbe Interactions |
title_short | Probiotics and MicroRNA: Their Roles in the Host–Microbe Interactions |
title_sort | probiotics and microrna: their roles in the host–microbe interactions |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7885260/ https://www.ncbi.nlm.nih.gov/pubmed/33603718 http://dx.doi.org/10.3389/fmicb.2020.604462 |
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