Engineering mono- and multi-valent inhibitors on a modular scaffold

Here we exploit the simple, ultra-stable, modular architecture of consensus-designed tetratricopeptide repeat proteins (CTPRs) to create a platform capable of displaying both single as well as multiple functions and with diverse programmable geometrical arrangements by grafting non-helical short lin...

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Detalles Bibliográficos
Autores principales: Diamante, Aurora, Chaturbedy, Piyush K., Rowling, Pamela J. E., Kumita, Janet R., Eapen, Rohan S., McLaughlin, Stephen H., de la Roche, Marc, Perez-Riba, Albert, Itzhaki, Laura S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7885266/
https://www.ncbi.nlm.nih.gov/pubmed/33623657
http://dx.doi.org/10.1039/d0sc03175e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7885266/
https://www.ncbi.nlm.nih.gov/pubmed/33623657
http://dx.doi.org/10.1039/d0sc03175e

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