IMPORTANCE trial: a provisional study-design of a single-center, phase II, double-blinded, placebo-controlled, randomized, 4-week study to compare the efficacy and safety of intranasal esketamine in chronic opioid refractory pain

Background:  Cancer is the second leading cause of death globally. Up to 86% of advanced cancer patients experience significant pain, while 10-20% live in chronic pain. Besides, increasing prescription of opioids resulted in 33,000 deaths in the US in 2015. Both reduce patients’ functional status an...

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Detalles Bibliográficos
Autores principales: Fernandes, Mauricio, Schelotto, Magdalena, Doldi, Philipp Maximilian, Milani, Giovanna, Ariza Manzano, Abul Andrés, Perera Valdivia, Doriam, Winter Matos, Alexandra Marie, Hamdy Abdelrahim, Yasmin, Hamad Bek, Shaza Ahmed, Benitez, Benito K., Romanelli Tavares, Vanessa Luiza, Basendwah, Abdulrahim M., Albuquerque Sousa, Luis Henrique, Xavier, Naiara Faria, Zertuche Maldonado, Tania, Toyomi de Oliveira, Sarah, Chaker, Melisa, Menon Miyake, Michelle, Uygur Kucukseymen, Elif, Waqar, Kinza, Alkhozondar, Ola M.J., Bernardo da Silva, Ricardo, Droppelmann, Guilhermo, Vaz de Macedo, Antonio, Nakamura, Rui, Fregni, Felipe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2021
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7885290/
https://www.ncbi.nlm.nih.gov/pubmed/33732434
http://dx.doi.org/10.12688/f1000research.27809.1

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