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Nucleolar stress in C9orf72 and sporadic ALS spinal motor neurons precedes TDP-43 mislocalization

Nucleolar stress has been implicated in the pathology and disease pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) from repeat expansions of GGGGCC in C9orf72 (C9-ALS/FTLD) but not in sporadic ALS (SALS). Previously we reported that antisense RNA trans...

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Detalles Bibliográficos
Autores principales:	Aladesuyi Arogundade, Olubankole, Nguyen, Sandra, Leung, Ringo, Wainio, Danielle, Rodriguez, Maria, Ravits, John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7885352/ https://www.ncbi.nlm.nih.gov/pubmed/33588953 http://dx.doi.org/10.1186/s40478-021-01125-6

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