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ABCB1 and ABCG2 restricts the efficacy of gedatolisib (PF-05212384), a PI3K inhibitor in colorectal cancer cells

BACKGROUND: Overexpression of ABC transporters is a big challenge on cancer therapy which will lead cancer cells resistance to a series of anticancer drugs. Gedatolisib is a dual PI3K and mTOR inhibitor which is under clinical evaluation for multiple types of malignancies, including colorectal cance...

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Detalles Bibliográficos
Autores principales:	Liu, Changfu, Xing, Wenge, Yu, Haipeng, Zhang, Weihao, Si, Tongguo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7885361/ https://www.ncbi.nlm.nih.gov/pubmed/33593355 http://dx.doi.org/10.1186/s12935-021-01800-7

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