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Identification of MFGE8 and KLK5/7 as mediators of breast tumorigenesis and resistance to COX-2 inhibition

BACKGROUND: Cyclooxygenase 2 (COX-2) promotes stemness in triple negative breast cancer (TNBC), highlighting COX-2 as a promising therapeutic target in these tumors. However, to date, clinical trials using COX-2 inhibitors in breast cancer only showed variable patient responses with no clear signifi...

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Detalles Bibliográficos
Autores principales:	Tian, Jun, Wang, Vivian, Wang, Ni, Khadang, Baharak, Boudreault, Julien, Bakdounes, Khldoun, Ali, Suhad, Lebrun, Jean-Jacques
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7885389/ https://www.ncbi.nlm.nih.gov/pubmed/33588911 http://dx.doi.org/10.1186/s13058-021-01401-2

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